User:Jliang

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{{Smolke_Top}}
==Joe C. Liang==
==Joe C. Liang==
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Graduate Student at [http://openwetware.org/wiki/Smolke Smolke Lab] <br/>
 
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Department of Chemical Engineering, MC 210-41<br/>
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[[Image:Joe.jpg|right|thumb]]
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California Institute of Technology<br/>
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Pasadena, CA 91125-4100<br/>
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(626)395-2753<br/>
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jliang @ caltech . edu
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Ph.D. Candidate <br/>
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Bioengineering -- [http://openwetware.org/wiki/Smolke Smolke Lab] <br/>
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Y2E2 Building, MC 4200 <br/>
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473 Via Ortega <br/>
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Stanford, CA 94305 <br/>
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Phone: (650) 721-5884 <br/>
==Education==
==Education==
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Ph.D Student, Chemical Engineering, Caltech, 2006-present <br/>
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Ph.D, Candidate, Chemical Engineering, Caltech, 2008-present <br/>
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B.S, Chemical Engineering with Emphasis in Applied Physical Science, UC Berkeley, 2006<br/>
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M.S, Chemical Engineering, Caltech, 2008 <br/>
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B.S, Chemical Engineering, UC Berkeley, 2006<br/>
==Research Interest==
==Research Interest==
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RNA aptamers are known to discriminate molecules in a highly sensitive way. One classic example is that the theophylline aptamer does not respond to caffeine though there is mere difference of one methyl group in structure. This superior sensitivity of aptmaers distinguishing molecules is a nice characteristic to be incorporated in a synthetic biological regulartory network, which usually consists of many structurally similar metabolites. However, the application of using aptamers in a synthetic pathway has been severely limited by the ability to generate functional aptamers ''in vivo'' effectivly. Traditional ''in vitro'' ''SELEX'' usually takes weeks in selection and characterizaion of aptamers and requires further screening for ''in vivo'' activities.
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I am developing enabling technologies that support generation of RNA devices.
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In the Smolke lab, we have developed several portable, modular, and tunable engineered RNA-based switch platform that can adopt to different conformations upon binding of various molecular inputs and subsequently modulates the level of target gene expression. We can then use the existing sensor domain of these switch platforms developed from ''SELEX'' and implement it as a selection tool to screen library in order to generate aptamers for other strucually similar molecules. The eventual goal is to incorporate these platforms as part of the regulatory network in a syntheitc biological pathway and redirect molecular fluxes to accumulate medicinal valuable intermediates that are too costly to be synthesized chemically.
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==Publications==
==Publications==
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<biblio>
 
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#liang1  [http://www.cs.caltech.edu/cbsss/finalreport/yjunction_group.pdf ''Y-Junction Carbon Nanotube Implementation of Intramolecular Electronic NAND Gate'']
 
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<br>Benjamin Gojman, Happy Hsin, Joe Liang, Natalia Nezhdanova, Jasmin Saini
 
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#liang2 ''Evaluation of Two Computational Models Based on Different Effective Core Potentials for Use in Organocesium Chemistry''
 
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<br>Streitwieser, A.; Liang, J. C.-Y.; Jayasree, E. G.; Hasanayn, F. J. Chem. Theory and Comput.; (Article); 2007; 3(1); 127-131
 
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</biblio>
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# Liang JC, Smolke CD. 2011. Rational design and tuning of ribozyme-based devices. In: Hartig J, editor. Methods in Molecular Biology. In press.
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# Win MN,  Liang JC, Smolke CD. 2010. Frameworks for programming RNA devices. In: Mayer G, editor. The Chemical Biology of Nucleic Acids. U.K.: John Wiley & Sons, Ltd. pp. 323-38.
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=Honors and Awards=
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Current revision

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Contents

Joe C. Liang

Ph.D. Candidate
Bioengineering -- Smolke Lab
Y2E2 Building, MC 4200
473 Via Ortega
Stanford, CA 94305
Phone: (650) 721-5884

Education

Ph.D, Candidate, Chemical Engineering, Caltech, 2008-present
M.S, Chemical Engineering, Caltech, 2008
B.S, Chemical Engineering, UC Berkeley, 2006

Research Interest

I am developing enabling technologies that support generation of RNA devices.

Publications

  1. Liang JC, Smolke CD. 2011. Rational design and tuning of ribozyme-based devices. In: Hartig J, editor. Methods in Molecular Biology. In press.
  2. Win MN, Liang JC, Smolke CD. 2010. Frameworks for programming RNA devices. In: Mayer G, editor. The Chemical Biology of Nucleic Acids. U.K.: John Wiley & Sons, Ltd. pp. 323-38.
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