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Joe Liang

Graduate Student at Smolke Lab

Department of Chemical Engineering, MC 210-41
California Institute of Technology
Pasadena, CA 91125-4100

jliang @ caltech . edu


Ph.D Student, Chemical Engineering, Caltech, 2006-present
B.S, Chemical Engineering wiht Applied Physical Science Emphasis, University of California at Berkeley, 2006

Research Interest

RNA aptamers are known to have high molecular discriminating ability. One classic example is that the theophylline aptamers does not respond in the presense of caffeine despite structurally differing in merely one methyl group. This superior sensitivity of aptmaers binding to metabolites is a nice trait to be incorportated in a synthetic biological regulartory network, which usually consists of many structurally similar intermeidates. However, the application of using aptamers in a synthetic pathway has been severely limited by the ability to effectivly generate functional aptamers in vivo. Traditional in vitro SELEX usually takes weeks in selection and characterizaion and requires further screening for in vivo functions. In the Smolke lab, we have developed several portable, modular, and tunable RNA-based switch platform that can adopt the conformations upon binding of various molecular inputs and thus modulates the level of target gene expression. The idea is to use these switch platforms as a search tool to screen ..more


  1. Y-Junction Carbon Nanotube Implementation of Intramolecular Electronic NAND Gate
    Benjamin Gojman, Happy Hsin, Joe Liang, Natalia Nezhdanova, Jasmin Saini [liang1]
  2. Evaluation of Two Computational Models Based on Different Effective Core Potentials for Use in Organocesium Chemistry
    Streitwieser, A.; Liang, J. C.-Y.; Jayasree, E. G.; Hasanayn, F. J. Chem. Theory and Comput.; (Article); 2007; 3(1); 127-131


Honors and Awards

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