User:Johnsy/Lipoprotein Modelling: Difference between revisions
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=Modelling Lipoprotein Metabolism= | =Modelling Lipoprotein Metabolism= | ||
'''BEng Final Year Individual Project 2007/2008'''<p> | '''BEng Final Year Individual Project 2007/2008'''<p> | ||
''John Sy'' | ''John Sy''<p> | ||
Supervisor: Mauricio Barahona, PhD | |||
Revision as of 05:47, 10 October 2007
Modelling Lipoprotein Metabolism
BEng Final Year Individual Project 2007/2008
John Sy
Supervisor: Mauricio Barahona, PhD
Aims
- Understand the pathways for maintaining cholesterol homeostasis in the human body and various diseased states resulting in a level of blood cholesterol away from homeostasis.
- Develop an understanding of how lipoproteins are transported into and out of the cells in the human body, especially hepatocytes.
- Reserach and understand current models of lipoprotein metabolism.
- Adapt and develop the current models of lipoprotein metabolism to more reflect the biochemistry of the process.
- Understand the importance of lipoproteins, especially LDL, to the generation of atherosclerosis.
- Understand the mechanism by which statins affect HMG-CoA reductase and develop a mathematical model to account for its actions.
- Test the model with various physiological parameters in an attempt to better understand the effects of diseases such as familial hypercholesterolemia (FH)
