User:Jon Sack

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(Research interests)
Current revision (23:36, 12 December 2012) (view source)
 
(29 intermediate revisions not shown.)
Line 1: Line 1:
-
<!-- Delete this entire line as part of your first edit of your user page --> {{New user}}
+
{{Template: Sack Lab}}
 +
[[Image:sackshot.jpg|thumb|right]]
 +
Jon Sack, Ph.D.
-
==Contact Info==
+
===Research interests===
-
[[Image:OWWEmblem.png|thumb|right|Jon Sack (an artistic interpretation)]]
+
-
Jon Sack
+
In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.
-
#Assistant Professional Researcher
+
-
#Department of Neurobiology, Physiology & Behavior, College of Biological Sciences
+
-
#University of California
+
-
#196 Briggs Hall, One Shields Avenue, Davis, CA 95616
+
-
#
+
-
*phone  530.752.4131
+
-
*mobile 650.384.5792
+
-
#
+
-
*jsack (at) ucdavid (dot) edu
+
-
==Education==
+
===Education===
-
<!--Include info about your educational background-->
+
-
* 2003 PhD, Stanford University, Department of Biological Sciences
+
-
* 1997, BA, Reed College, Major in Biochemistry
+
-
==Research interests==
+
Ph.D., Stanford University, Department of Biological Sciences
-
<!-- Feel free to add brief descriptions to your research interests as well -->
+
-
# Interest 1
+
-
# Interest 2
+
-
# Interest 3
+
-
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed -->
+
-
==Useful links==
+
B.A., Reed College, Biochemistry
-
*[[OpenWetWare:Welcome|Introductory tutorial]]
+
 
-
*[[Help|OpenWetWare help pages]]
+
===Institutional Affiliation===
 +
 
 +
Assistant Professor
 +
 
 +
Department of Physiology & Membrane Biology
 +
 
 +
School of Medicine
 +
 
 +
University of California
 +
 
 +
4126 Tupper Hall
 +
 
 +
One Shields Avenue
 +
 
 +
Davis, California 95616
 +
 
 +
530.752.4131 tel
 +
 
 +
530.752.5314 lab tel
 +
 
 +
530.752.5423 fax

Current revision


Sack and Yarov-Yarovoy Labs

Department of Physiology and Membrane Biology
University of California, Davis

Home        Research        People        Contact        Protocols        Resources       


Jon Sack, Ph.D.

Research interests

In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.

Education

Ph.D., Stanford University, Department of Biological Sciences

B.A., Reed College, Biochemistry

Institutional Affiliation

Assistant Professor

Department of Physiology & Membrane Biology

School of Medicine

University of California

4126 Tupper Hall

One Shields Avenue

Davis, California 95616

530.752.4131 tel

530.752.5314 lab tel

530.752.5423 fax

Personal tools