User:Jon Sack

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Jon Sack, Ph.D.
Jon Sack, Ph.D.
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Protean Research and the University of California
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===Research interests===
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In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.
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==Research interests==
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===Education===
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Electrical signaling in living cells controls a wide variety of arguably important physiological processes such as feeling, thinking, and heartbeat. Electrophysiological signals are created by proteins known as ion channels, and modulating the behavior of ion channels will alter the processes they control.  The goal of my research program is to develop modulators selective for ion channel subtypes, to more precisely alter electrophysiological signals and identify channel subunits that generate native currents.  Establishing the molecular identity of voltage-gated potassium (Kv) channels has been a particularly challenging problem: mammalian channels arise from a family of more than 40 genes, and pore-forming subunits can assemble as heterotetramers. Despite substantial and enduring efforts, few modulators of Kv channel activity have been discovered that are highly selective between  channel subtypes.  This is perhaps due to a high degree of sequence conservation between subfamily members in functionally important transmembrane segments. Our research efforts seek to enhance the selectivity of channel modulators by covalent attachment to benign, yet well-targeted, biologics.
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Ph.D., Stanford University, Department of Biological Sciences
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==Education==
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B.A., Reed College, Biochemistry  
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* Ph.D., Stanford University, Department of Biological Sciences
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* B.A., Reed College, Biochemistry
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==Institutional Affiliations==
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===Institutional Affiliation===
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Founder
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Institute for Design of Intelligent Drugs
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Assistant Professor
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Protean Research
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Department of Physiology & Membrane Biology
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941 Roble Ridge
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School of Medicine
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Palo Alto, California 94306
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650.384.5792 tel 
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650.716.5222 fax
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jon (at) sack (at) ididrugs (dot) org
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Assistant Professional Researcher
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Department of Neurobiology, Physiology & Behavior
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College of Biological Sciences
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University of California
University of California
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196 Briggs Hall
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4126 Tupper Hall
One Shields Avenue
One Shields Avenue
Line 48: Line 31:
530.752.4131 tel
530.752.4131 tel
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530.754.6079 fax
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530.752.5314 lab tel
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jsack (at) ucdavis (dot) edu
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530.752.5423 fax

Current revision


Sack and Yarov-Yarovoy Labs

Department of Physiology and Membrane Biology
University of California, Davis

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Jon Sack, Ph.D.

Research interests

In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.

Education

Ph.D., Stanford University, Department of Biological Sciences

B.A., Reed College, Biochemistry

Institutional Affiliation

Assistant Professor

Department of Physiology & Membrane Biology

School of Medicine

University of California

4126 Tupper Hall

One Shields Avenue

Davis, California 95616

530.752.4131 tel

530.752.5314 lab tel

530.752.5423 fax

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