User:Jon Sack - Revision history

Daniel Clay Austin at 03:36, 13 December 2012

Daniel Clay Austin — Thu, 13 Dec 2012 03:36:25 GMT

←Older revision		Revision as of 03:36, 13 December 2012
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	530.752.5423 fax		530.752.5423 fax
-
-	*Return to [[Sack]] Homepage

Daniel Clay Austin at 03:30, 13 December 2012

Daniel Clay Austin — Thu, 13 Dec 2012 03:30:14 GMT

←Older revision		Revision as of 03:30, 13 December 2012
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-	[[Template: Sack Lab]]	+	{{Template: Sack Lab}}
	[[Image:sackshot.jpg\|thumb\|right]]		[[Image:sackshot.jpg\|thumb\|right]]
	Jon Sack, Ph.D.		Jon Sack, Ph.D.

Daniel Clay Austin at 03:29, 13 December 2012

Daniel Clay Austin — Thu, 13 Dec 2012 03:29:24 GMT

←Older revision		Revision as of 03:29, 13 December 2012
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		+	[[Template: Sack Lab]]
	[[Image:sackshot.jpg\|thumb\|right]]		[[Image:sackshot.jpg\|thumb\|right]]
	Jon Sack, Ph.D.		Jon Sack, Ph.D.

Jon Sack at 02:38, 4 October 2012

Jon Sack — Thu, 04 Oct 2012 02:38:26 GMT

←Older revision		Revision as of 02:38, 4 October 2012
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	[[Image:sackshot.jpg\|thumb\|right]]		[[Image:sackshot.jpg\|thumb\|right]]
-	Jon Sack, Ph.D.===Research interests===	+	Jon Sack, Ph.D.
		+
		+	===Research interests===

	In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.		In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.

Jon Sack at 02:38, 4 October 2012

Jon Sack — Thu, 04 Oct 2012 02:38:14 GMT

←Older revision		Revision as of 02:38, 4 October 2012
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	[[Image:sackshot.jpg\|thumb\|right]]		[[Image:sackshot.jpg\|thumb\|right]]
-	Jon Sack, Ph.D.	+	Jon Sack, Ph.D.===Research interests===
		+
		+	In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.
		+
		+	===Education===
		+
		+	Ph.D., Stanford University, Department of Biological Sciences
		+
		+	B.A., Reed College, Biochemistry
		+
		+	===Institutional Affiliation===
		+
		+	Assistant Professor
		+
		+	Department of Physiology & Membrane Biology
		+
		+	School of Medicine
		+
		+	University of California
		+
		+	4126 Tupper Hall
		+
		+	One Shields Avenue
		+
		+	Davis, California 95616
		+
		+	530.752.4131 tel
		+
		+	530.752.5314 lab tel
		+
		+	530.752.5423 fax
		+
		+	*Return to [[Sack]] Homepage

Jon Sack: /* Institutional Affiliation */

Jon Sack — Wed, 03 Oct 2012 22:02:41 GMT

Institutional Affiliation

←Older revision		Revision as of 22:02, 3 October 2012
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	[[Image:sackshot.jpg\|thumb\|right]]		[[Image:sackshot.jpg\|thumb\|right]]
	Jon Sack, Ph.D.		Jon Sack, Ph.D.
-
-
-
-
-
-	~~==Institutional Affiliation==~~
-
-	~~Assistant Professor~~
-
-	~~Department of Physiology & Membrane Biology~~
-
-	~~School of Medicine~~
-
-	~~University of California~~
-
-	~~4126 Tupper Hall~~
-
-	~~One Shields Avenue~~
-
-	~~Davis, California 95616~~
-
-	~~530.752.4131 tel~~
-
-	~~530.752.5314 lab tel~~
-
-	~~530.752.5423 fax~~
-
-	~~jsack at ucdavis dot edu~~

Jon Sack: /* Education */

Jon Sack — Wed, 03 Oct 2012 22:02:00 GMT

Education

←Older revision		Revision as of 22:02, 3 October 2012
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-	~~==Education==~~	+
-	~~<!--Include info about your educational background-->~~	+
-	* Ph.D., Stanford University, Department of Biological Sciences	+
-	* B.A., Reed College, Biochemistry	+

	==Institutional Affiliation==		==Institutional Affiliation==

Jon Sack at 02:57, 2 October 2012

Jon Sack — Tue, 02 Oct 2012 02:57:55 GMT

←Older revision		Revision as of 02:57, 2 October 2012
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	Jon Sack, Ph.D.		Jon Sack, Ph.D.

-	~~==Research interests==~~	+
-	In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.	+

	==Education==		==Education==

Jon Sack: /* Research interests */

Jon Sack — Thu, 17 May 2012 05:17:58 GMT

Research interests

←Older revision		Revision as of 05:17, 17 May 2012
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	==Research interests==		==Research interests==
-	~~Electrical signaling in~~ living cells ~~controls~~ a ~~wide variety~~ of ~~arguably~~ important physiological processes ~~such as feeling~~, ~~thinking~~, and heartbeat. Electrophysiological signals are ~~created~~ by proteins known as ion channels~~, and modulating the behavior of ion channels will alter the processes they control~~. ~~The goal~~ of ~~my research program is to develop modulators selective for ion channel subtypes~~, to ~~more precisely alter electrophysiological signals and identify channel subunits that generate native currents~~. Establishing the ~~molecular~~ identity of ~~voltage-gated potassium (Kv) channels~~ has been a particularly challenging problem~~: mammalian~~ channels arise from a family of more than 40 genes~~, and~~ pore-forming subunits can assemble as heterotetramers~~. Despite substantial and enduring efforts~~, ~~few modulators~~ of ~~Kv channel activity have been discovered that~~ are ~~highly~~ selective ~~between channel subtypes~~. ~~This~~ is ~~perhaps due~~ to ~~a high degree of sequence conservation between subfamily members in functionally~~ important ~~transmembrane segments~~. ~~Our research efforts seek~~ to ~~enhance~~ the ~~selectivity~~ of channel ~~modulators by covalent attachment to benign~~, ~~yet well-targeted, biologics~~.	+	In living cells, electrical signals control a cornucopia of important physiological processes including neurotransmission, insulin secretion, and heartbeat. Electrophysiological signals are generated by proteins known as ion channels. Different cell types harbor distinct complements of channels, tuned to serve the particular functions of a cell. Establishing the identity of proteins underlying endogenous ionic currents in any particular cell type has been particularly challenging problem. Mammalian voltage-gated potassium channels are exemplars of protein diversity. They arise from a family of more than 40 genes encoding pore-forming subunits, many of which can co-assemble into functionally distinct heterotetramers, which then recruit a variety of modulatory subunits. There are no selective inhibitors for most of these proteins, and more advanced tools are needed to identify the channels underlying endogenous potassium currents. The Sack laboratory is developing serial strategies to molecularly identify the channels that underlie important yet unidentified ionic currents. By using engineering biologic macromolecules and implementing ligand evolution strategies, we are developing novel means to target specific potassium channel gene products. The new biochemical tools are being used to probe the physiological function of specific ion channel proteins, and modulate cellular electrical signaling.

	==Education==		==Education==

Jon Sack at 04:07, 8 March 2011

Jon Sack — Tue, 08 Mar 2011 04:07:56 GMT

←Older revision		Revision as of 04:07, 8 March 2011
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	==Institutional Affiliation==		==Institutional Affiliation==

-	Assistant ~~Professional Researcher~~	+	Assistant Professor

-	Department of ~~Neurobiology,~~ Physiology & ~~Behavior~~	+	Department of Physiology & Membrane Biology

-	~~College~~ of ~~Biological Sciences~~	+	School of Medicine

	University of California		University of California

-	~~196 Briggs~~ Hall	+	4126 Tupper Hall

	One Shields Avenue		One Shields Avenue
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	530.752.4131 tel		530.752.4131 tel

-	530.~~754~~.~~6079 fax~~	+	530.752.5314 lab tel

-	jsack (at) ucdavis (dot) edu	+	530.752.5423 fax
		+
		+	jsack at ucdavis dot edu