User:Joshua S. Waitzman - Revision history

Joshua S. Waitzman: /* Publications */

Joshua S. Waitzman — Wed, 01 Feb 2012 19:45:10 GMT

Publications

←Older revision		Revision as of 19:45, 1 February 2012
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	<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed -->		<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed -->
	<biblio>		<biblio>
-	#Paper1 pmid=20585387	+	#Paper1 pmid=22261065
		+	#Paper2 pmid=20585387
	// This work's been picked up by the Science [http://podcasts.aaas.org/science_news/SciencePodcast_100618_ScienceNOW.mp3] and Scientific American [http://www.scientificamerican.com/podcast/episode.cfm?id=soccer-players-ranked-with-network-10-06-17] podcasts!		// This work's been picked up by the Science [http://podcasts.aaas.org/science_news/SciencePodcast_100618_ScienceNOW.mp3] and Scientific American [http://www.scientificamerican.com/podcast/episode.cfm?id=soccer-players-ranked-with-network-10-06-17] podcasts!
-	#~~Paper2~~ pmid=17686972	+	#Paper3 pmid=17686972

	</biblio>		</biblio>

Joshua S. Waitzman: /* Contact Info */

Joshua S. Waitzman — Sat, 10 Jul 2010 01:25:32 GMT

Contact Info

←Older revision		Revision as of 01:25, 10 July 2010
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	*[[Special:Emailuser/Joshua S. Waitzman\|Email me through OpenWetWare]]		*[[Special:Emailuser/Joshua S. Waitzman\|Email me through OpenWetWare]]

-	I'm an MD/PhD student working in the Rice Lab at Northwestern	+	I'm an MD/PhD student working in the [http://openwetware.org/wiki/Rice_Lab Rice Lab] at Northwestern

	==Education==		==Education==

Joshua S. Waitzman at 01:23, 10 July 2010

Joshua S. Waitzman — Sat, 10 Jul 2010 01:23:34 GMT

←Older revision		Revision as of 01:23, 10 July 2010
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	*Joshua S. Waitzman		*Joshua S. Waitzman
-	*~~<br>~~Ward 8-321	+	*Ward 8-321
-	~~<br>~~Department of Cell and Molecular Biology	+	*Department of Cell and Molecular Biology
-	~~<br>~~Feinberg School of Medicine, Northwestern University	+	*Feinberg School of Medicine, Northwestern University
-	~~<br>~~Chicago, IL, USA 60611	+	*Chicago, IL, USA 60611
	*[[Special:Emailuser/Joshua S. Waitzman\|Email me through OpenWetWare]]		*[[Special:Emailuser/Joshua S. Waitzman\|Email me through OpenWetWare]]

Joshua S. Waitzman: /* Contact Info */

Joshua S. Waitzman — Sat, 10 Jul 2010 01:23:13 GMT

Contact Info

←Older revision		Revision as of 01:23, 10 July 2010
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	*Joshua S. Waitzman		*Joshua S. Waitzman
-	<br>Ward 8-321	+	*<br>Ward 8-321
	<br>Department of Cell and Molecular Biology		<br>Department of Cell and Molecular Biology
	<br>Feinberg School of Medicine, Northwestern University		<br>Feinberg School of Medicine, Northwestern University

Joshua S. Waitzman: /* Contact Info */

Joshua S. Waitzman — Sat, 10 Jul 2010 01:22:52 GMT

Contact Info

←Older revision		Revision as of 01:22, 10 July 2010
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	*Joshua S. Waitzman		*Joshua S. Waitzman
-	*Ward 8-321	+	<br>Ward 8-321
-	*Department of Cell and Molecular Biology	+	<br>Department of Cell and Molecular Biology
-	*Feinberg School of Medicine, Northwestern University	+	<br>Feinberg School of Medicine, Northwestern University
-	*Chicago, IL, USA 60611	+	<br>Chicago, IL, USA 60611
	*[[Special:Emailuser/Joshua S. Waitzman\|Email me through OpenWetWare]]		*[[Special:Emailuser/Joshua S. Waitzman\|Email me through OpenWetWare]]

Joshua S. Waitzman: /* Useful links */

Joshua S. Waitzman — Sat, 10 Jul 2010 01:22:17 GMT

Useful links

←Older revision		Revision as of 01:22, 10 July 2010
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	==Useful links==		==Useful links==
-	*~~Northwestern Medical Scientist Training Program~~[http://mstp.northwestern.edu/]	+	*[http://mstp.northwestern.edu/ Northwestern Medical Scientist Training Program]
-	*~~Northwestern Cellular and Molecular Basis of Disease Training Grant~~[http://www.biochem.northwestern.edu/cmbd/]	+	*[http://www.biochem.northwestern.edu/cmbd/ Northwestern Cellular and Molecular Basis of Disease Training Grant]
-	*~~Hertz Foundation~~[http://www.hertzfoundation.org/]	+	*[http://www.hertzfoundation.org/ Hertz Foundation]

Joshua S. Waitzman: /* Research interests */

Joshua S. Waitzman — Sat, 10 Jul 2010 01:21:21 GMT

Research interests

←Older revision		Revision as of 01:21, 10 July 2010
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	==Research interests==		==Research interests==
-	In order to divide and proliferate, a single cell must distribute its chromsomes equally to daughter cells by establishing a microtubule-based spindle. Kinesin-5 is a microtubule motor protein that plays an essential role in aligning this spindle structure. As a hallmark of cancer cells is their increased ability to divide, ~~Eg5~~ and other mitotic motor proteins are promising drug targets for cancer therapy, and ispinesib, a specific inhibitor of ~~Eg5~~, is in Phase II FDA trials for non-small cell lung cancer and glioblastoma multiforme.	+	In order to divide and proliferate, a single cell must distribute its chromsomes equally to daughter cells by establishing a microtubule-based spindle. Kinesin-5 is a microtubule motor protein that plays an essential role in aligning this spindle structure. As a hallmark of cancer cells is their increased ability to divide, kinesin-5 and other mitotic motor proteins are promising drug targets for cancer therapy, and ispinesib, a specific inhibitor of kinesin-5, is in Phase II FDA trials for non-small cell lung cancer and glioblastoma multiforme.

-	~~Eg5~~ is believed to be regulated by phosphorylation by both M-Cdk and Wee1, kinases known to play roles in the cell cycle. However, the structural mechanisms of this phospho-regulation are unknown. My work uses structural biology and biochemistry approaches to determine the phosphorylation-dependent changes in ~~Eg5~~. Our group uses Electron Paramagnetic Resonance (EPR) spectroscopy to monitor the freedom of movement of different parts of the ~~Eg5~~ protein, as well as kinetic measurements of the protein's activity. By combining these approaches, we hope to clarify the relationships between structure and activity in ~~Eg5~~ and may be able to guide future drug discovery efforts.	+	Kinesin-5 is believed to be regulated by phosphorylation by both M-Cdk and Wee1, kinases known to play roles in the cell cycle. However, the structural mechanisms of this phospho-regulation are unknown. My work uses structural biology and biochemistry approaches to determine the phosphorylation-dependent changes in kinesin-5. Our group uses Electron Paramagnetic Resonance (EPR) spectroscopy to monitor the freedom of movement of different parts of the kinesin-5 protein, as well as kinetic measurements of the protein's activity. By combining these approaches, we hope to clarify the relationships between structure and activity in kinesin-5 and may be able to guide future drug discovery efforts.

	==Publications==		==Publications==

Joshua S. Waitzman at 17:27, 9 July 2010

Joshua S. Waitzman — Fri, 09 Jul 2010 17:27:24 GMT

←Older revision		Revision as of 17:27, 9 July 2010
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	==Contact Info==		==Contact Info==
-	[[Image:~~OWWEmblem~~.~~png~~\|thumb\|right\|Joshua S. Waitzman ~~(an artistic interpretation)~~]]	+	[[Image:Waitzman.jpg\|thumb\|right\|Joshua S. Waitzman]]

	*Joshua S. Waitzman		*Joshua S. Waitzman

Joshua S. Waitzman at 17:24, 9 July 2010

Joshua S. Waitzman — Fri, 09 Jul 2010 17:24:17 GMT

←Older revision		Revision as of 17:24, 9 July 2010
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	==Research interests==		==Research interests==
		+	In order to divide and proliferate, a single cell must distribute its chromsomes equally to daughter cells by establishing a microtubule-based spindle. Kinesin-5 is a microtubule motor protein that plays an essential role in aligning this spindle structure. As a hallmark of cancer cells is their increased ability to divide, Eg5 and other mitotic motor proteins are promising drug targets for cancer therapy, and ispinesib, a specific inhibitor of Eg5, is in Phase II FDA trials for non-small cell lung cancer and glioblastoma multiforme.

		+	Eg5 is believed to be regulated by phosphorylation by both M-Cdk and Wee1, kinases known to play roles in the cell cycle. However, the structural mechanisms of this phospho-regulation are unknown. My work uses structural biology and biochemistry approaches to determine the phosphorylation-dependent changes in Eg5. Our group uses Electron Paramagnetic Resonance (EPR) spectroscopy to monitor the freedom of movement of different parts of the Eg5 protein, as well as kinetic measurements of the protein's activity. By combining these approaches, we hope to clarify the relationships between structure and activity in Eg5 and may be able to guide future drug discovery efforts.

	==Publications==		==Publications==
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	==Useful links==		==Useful links==
-	*[~~[OpenWetWare~~:~~Welcome\|Introductory tutorial]~~]	+	*Northwestern Medical Scientist Training Program[http://mstp.northwestern.edu/]
-	*[~~[Help\|OpenWetWare help pages~~]]	+	*Northwestern Cellular and Molecular Basis of Disease Training Grant[http://www.biochem.northwestern.edu/cmbd/]
		+	*Hertz Foundation[http://www.hertzfoundation.org/]

Joshua S. Waitzman at 16:49, 9 July 2010

Joshua S. Waitzman — Fri, 09 Jul 2010 16:49:02 GMT

←Older revision		Revision as of 16:49, 9 July 2010
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	#Paper1 pmid=20585387		#Paper1 pmid=20585387
	// This work's been picked up by the Science [http://podcasts.aaas.org/science_news/SciencePodcast_100618_ScienceNOW.mp3] and Scientific American [http://www.scientificamerican.com/podcast/episode.cfm?id=soccer-players-ranked-with-network-10-06-17] podcasts!		// This work's been picked up by the Science [http://podcasts.aaas.org/science_news/SciencePodcast_100618_ScienceNOW.mp3] and Scientific American [http://www.scientificamerican.com/podcast/episode.cfm?id=soccer-players-ranked-with-network-10-06-17] podcasts!
-	//
	#Paper2 pmid=17686972		#Paper2 pmid=17686972