I work on the regulation of DNA replication in Bacillus subtilis.
My research interest is to systematically investigate how cells regulate DNA replication to maintain genomic integrity. By profiling DNA replication in the gram-positive bacterium Bacillus subtilis on a genomic scale, I have characterized a nutrient dependent checkpoint that inhibits the elongation of DNA replication. I plan to investigate the mechanisms and the impact of elongation control on regulating the cell cycle and preventing disruptions of replication. I will combine classical genetics, biochemistry, and global profiling of replication to study replication in a quantitative manner and analyze the results computationally. The experimental methods developed could also be useful to study the regulation of DNA replication in other organisms.