User:Jungwhan Kim

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JHIBRG Co-CHIEF

Jungwhan Kim, D.V.M., Ph.D.

Post-Doctoral Fellow (Dr. Zena Werb Lab)

University of California, San Francisco (UCSF), School of Medicine

Email: vetjayk@gmail.com, vetjayk@yahoo.com

Research Interests

Cell Metabolism Cover Mar 2006

I have been studying the molecular mechanisms underlying oncogenic alterations of cellular metabolism by the c-Myc oncoprotein (Myc Target Gene Database). c-Myc heterodimerizes with Max to bind specific DNA sequences (CACGTG), termed E box and transactivates its target genes. Using phylogenetic footprinting and chromatin immunoprecipitation (ChIP) assays, I found that c-Myc overexpression activates genes encoding proteins involved in glycolysis and contributes to the Warburg effect or aerobic glycolysis, which is characteristic of essentially all solid tumors (Kim. J. et.al. MCB, 2004). I also have been studying metabolic reprogramming of cells in response to hypoxia. I found that hypoxic induction of pyruvate dehydrogenase kinase 1 (PDK1) actively suppresses mitochondrial functions, which results in preserving oxygen consumption and attenuating ROS production under hypoxic conditions (Kim J. et. al. Cell Metabolism, 2006).This metabolic shift confers optimization of efficient respiration of hypoxic cells, which contributes to tumor progression under hypoxic microenvironment. These studies lead to the concept that tumor bioenergetics derived from either cell autonomous oncogenic events or adaptive responses to hypoxic microenvironment could be an attractive target for the cancer therapeutics.

Education

• D.V.M. (1995 Mar -2000 Feb) : Kon-kuk University, School of Veterinary Medicine, Seoul, Korea (Summa cum Laude)
• Ph.D. (2002 Sep -2006 Feb) : Johns Hopkins, School of Medicine (Pathobiology), Maryland, USA (Mentor, Chi V. Dang, M.D., Ph.D.)

Professional Training and Academic Awards

• Researcher; 2000 Feb - 2000 Sep ; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea
• Achievement Award for the 1st rank in The Veterinary National Board Examination, 2000, Korea
• Post-Doctoral Fellow; 2000 - 2002 ; University of Pennsylvania, School of Medicine, Dept. of Pathology & Lab Medicine (Supervisor; Ruth J. Muschel, M.D., Ph.D.)
• Howard Hughes Medical Institute (HHMI), Pre-Doctoral Fellowship (2003 - 2006)
• Post-Doctoral Fellow; 2006 - 2007 ; Johns Hopkins University, School of Medicine, Maryland, USA. Dept. of Medicine (Supervisor; Chi V. Dang, M.D., Ph.D.)
• Post-Doctoral Fellow; 2007 - present ; University of California San Francisco, School of Medicine, California, USA (Supervisor; Zena Werb, Ph.D.)

Publications (Link to Full Text)

1. Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza and Chi V. Dang. HIF-1 and dysregulated c-Myc cooperatively induce VEGF and metabolic switches, HK2 and PDK1. Submitted
2. Chi V. Dang, Ping Gao and Jung-whan Kim. The Warburg effect and tumor metabolism. Encyclopedia of CANCER (2007) In press
3. Jung-whan Kim, Ping Gao, and Chi V. Dnag. Effects of hypoxia on tumor metabolism. Cancer and Metastasis Reviews. (2007) In press
4. Ryo Fukuda, Huafeng Zhang, Jung-whan Kim, Larissa Shimoda, Chi V. Dang, and Gregg L. Semenza. HIF-1 regulates cytochrome oxidase subunit composition to optimize the efficiency of respiration of hypoxic cells. Cell 129:111-122 (2007)
5. Jung-whan Kim, and Chi V. Dang. Cancer’s molecular sweet tooth and the Warburg effect. Cancer Research 66:8927-8930 (2006)
6. Jung-whan Kim, Irina Tchernyshyov, Gregg L. Semenza, and Chi V. Dang. HIF-1-mediated expression of PDK: a metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3:177-185 (2006)
7. Ruth J. Muschel, Wili Fu, Jung-whan Kim, Yong Jiang, Jong-Young Lee, M. Margarida Bernardo, Bernd Arnold, Francis J. Deschamps, Ghislain Opdenakker and Rafi Fridman. MMP-9 Enhances Arrest of Tumor Cells in The Pulmonary Vasculature: A Mechanism to Promote Metastasis. Submitted
8. Kathryn O’Donnell, Duonan Yu, Karen I. Zeller, Jung-whan Kim, Frederick Racke, Andrei Thomas-Tikhonenko and Chi V. Dang. Transferrin Receptor 1 is a direct Myc target gene required for cell cycle progression, Molecular and Cellular Biology 26:2373-2386 (2006)
9. Rong Mao, Xiaowen Wang, Edward L. Spitznagel Jr., Laurence P. Frelin, Jason C. Ting, Huashi Ding, Jung-whan Kim, Ingo Ruczinski, Thomas J. Downey, and Jonathan Pevsner. Role of Gene Expression in the Developing Human Down Syndrome Brain and Heart. Genome Biology, 6:R107 (2005)
10. Jung-whan Kim, Lawrence B. Gardner and Chi V. Dang. Oncogenic Alterations of Metabolism and the Warburg Effect. Drug Discovery Today: Disease Mechanisms, 2:233-235 (2005)
11. Feng Li, Diane Wonsey, Young Ko, Kathryn O’Donnell, Karen I. Zeller, Jung-whan Kim, Jason Yustein, Linda A. Lee and Chi V. Dang. Myc stimulates mitochondrial biogenesis and nuclear encoded mitochondrial genes, Molecular and Cellular Biology. 25: 6225-6234 (2005)
12. Jung-whan Kim and Chi V. Dang. Multifaceted Roles of Glycolytic Enzymes. Trends in Biochemical Sciences, 30:142-150 (2005)
13. Seung-Hoon Lee, Jung-whan Kim, Sun-Hee Oh, Yong-Jin Kim, Seung-Bae Rho, Kyungsook Park, Kui-Lea Park and Je-ho Lee. IFN-gamma/IRF-1-induced p27 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Letters,579:1027-1033 (2005)
14. Jung-whan Kim, Karen I. Zeller, Yunyue Wang, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O’Donnell, and Chi V. Dang. Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays. Molecular and Cellular Biology, 24:5923-5936 (2004)
15. Jung-whan Kim, Christopher W. Wong, Jeffery D. Goldsmith, C.Song, Weili Fu, Mary-Beth Allion, Meenhard Herlyn, Abu B. Al-Mehdi, and Ruth J. Muschel. Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Letters, 213:203-212 (2004)
16. Seung-Hoon Lee, Jung-whan Kim, Yongsuk Cho, Sunhee Oh, Hanwoong Lee, Wei Zhang and Jeho Lee. Interferon Regulatory Factor 1 (IRF-1) Is a Mediator for Interferon-g-induced Attenuation of Telomerase Activity and Human Telomerase Reverse Transcriptase (hTERT) Expression. Oncogene,22:381-391 (2003)
17. Seung-Hoon Lee, Wei Zhang, Jung-joo Choi, Yong-Suk Cho, Sun-Hee Lee, Jung-whan Kim, Limei Hu, Jie Xu, Jinsong Liu and Joho Lee. Overexpression of the Thymosin beta-10 Gene in Human Ovarian Cancer Cells Disrupts F-Actin Stress Fiber and Leads to Apoptosis. Oncogene,20:6700-6706 (2001)
18. Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001)

When Disconnected

• Gundam Collection
• Skiing
• Baseball
• IS and RDX