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| |[[Image:Kun_zhang_pic1.jpg|100px]]|| | | |[[Image:Kun_zhang_pic1.jpg|100px]]|| |
| <b>Kun Zhang, Ph.D.</b><br> | | <b>Kun Zhang, Ph.D.</b><br> |
| Assistant Professor<br>
| | Associate Professor<br> |
| Department of Bioengineering<br> | | Department of Bioengineering<br> |
| University of California, San Diego<br> | | University of California, San Diego<br> |
| 9500 Gilman Drive, MC0412<br> | | 9500 Gilman Drive, MC0412<br> |
| La Jolla, CA 92903<br> | | La Jolla, CA 92903<br> |
| | [http://zhang.openwetware.org Zhang Lab Website] |
| |} | | |} |
| ==Education==
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| *Post-doc, Department of Genetics, Harvard Medical School
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| *Ph.D., Human and Molecular Genetics, University of Texas-Houston/MD-Anderson Cancer Center
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| *M.S., Neuroscience, Fudan University, China
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| *B.S., Biophysics, Fudan University, China
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| ==Research Interests== | | ==Research Interests== |
| We are developing genome technologies based on single-molecule sequencing, single-cell manipulation/amplification, and chip-based synthesis and manipulation of complex DNA libraries. We apply these novel technologies to stem cell genomics, personal genome and bioenergy research. | | We are developing genome technologies related to single-cell analyses of genome, transcriptome and epigenome, as well as single-cell imaging and lineage tracing. We apply these novel technologies to stem cell fate conversion, human brain mapping and human disease studies. |
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| ==Publications== | | ==Publications== |
| #Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, <b>Zhang K</b>, Melton DA, and Eggan K. (2009) Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. <b>Cell Stem Cell</b> 4:103-6
| | *[https://scholar.google.com/citations?user=CYeurYgAAAAJ&hl=en Google Scholar Page]. |
| #Porreca PJ, <b>Zhang K (co-first author)</b>, Li JB, Xie B, Austin D, Vassallo SL, Leproust EM, Peck BJ, Emig CJ, Dahl F, Gao Y, Church GM, Shendure J. (2007) Multiplex amplification of large sets of human exons. <b>Nat. Methods</b> 4:931-6.
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| #Kowalchuk GA, Speksnijder AG, <b>Zhang K</b>, Goodman RM, van Veen JA. (2007) Finding the needles in the metagenome haystack. <b>Microb. Ecol.</b> 53:475-85
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| #<b>Zhang K</b>, Lott ST, Jin L, Killary AM. (2007) Fine mapping of the NRC-1 tumor suppressor locus within chromosome 3p12. <b>Biochem. Biophys. Res. Commun.</b> 360:531-538
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| #<b>Zhang K</b>, Martiny AC, Reppas NB, Barry KW, Malek J, Chisholm SW, Church GM. (2006) Sequencing genomes from single cells by polymerase cloning. <b>Nat. Biotech.</b> 24:680-686
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| #<b>Zhang K</b>, Zhu J, Shendure J, Porreca GJ, Aach JD, Mitra RD, Church GM. (2006) Polony haplotyping of individual human chromosome molecules. <b>Nat. Genet.</b> 38:382-387.
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| #Shendure J, Porreca GJ, Reppas NB, Lin X, McCutcheon JP, Rosenbaum AM, Wang MD, <b>Zhang K</b>, Mitra RD, Church GM. (2005) Accurate multiplex polony sequencing of an evolved bacterial genome. <b>Science</b> 309:1728-1732.
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| #<b>Zhang K</b>, and Jin L. (2003) HaploBlockFinder: haplotype block analyses. <b>Bioinformatics</b> 19:1300-1301
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| #<b>Zhang K</b>, Akey JM (co-first author), Wang N, Xiong M, Chakraborty R, Jin L.(2003) Randomly distributed crossovers may generate block-like pattern of linkage disequibrium: An act of genetic drift. <b>Hum. Genet.</b> 113: 51-59.
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| #Akey JM, <b>Zhang K</b>, Xiong M, and Jin L. (2003) The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibrium. <b>Mol Biol Evol.</b> 20: 232-242.
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| #Akey JM, Zhang G, Z<b>hang K</b>, Jin L and Shriver M. (2002) Interrogating a high-density SNP map for signatures of natural selection. <b>Genome Res.</b> 12: 1805-1814.
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| #Wang N, Akey JM, <b>Zhang K</b>, Chakraborty R, Jin L. (2002) Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. <b>Am. J. Hum. Genet.</b> 71: 1227-1234.
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| #Akey DT, Akey JM, <b>Zhang K</b>, Jin L. (2002) Assaying DNA methylation based on high-throughput melting curve approaches. <b>Genomics</b> 80: 376-384.
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| #Akey JM, <b>Zhang K (co-first author)</b>, Xiong M, Doris P, Jin L. (2001) The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures. <b>Am. J. Hum. Genet.</b>, 68:1447-1456.
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