User:Lance Martin: Difference between revisions
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**Elowitz repressilator | **Elowitz repressilator | ||
[[Media:Modeling.ppt]] | [[Media:Modeling.ppt]] | ||
[[Image:PriorWork.jpg|thumb|right|Some engineered biological memory & logic systems]] | |||
===Prior work: implementing recombinase switches=== | |||
*Ham & Arkin inversion switch | |||
**[[Media:Ham&Arkin.ppt]] | |||
*Harvard/BU 2004 iGem Int/Xis inversion switch & counter | |||
**Their final presentation | |||
***[[Media:iGem.ppt]] | |||
**Notes on this work | |||
***[[Media:iGemLance.ppt]] | |||
===Challenges=== | |||
*No spatial addressing of signals in biological systems | |||
*Many heterogeneous parts implemented, resulting in: | |||
**Heterogeneity of device physics across circuits | |||
**Complex properties, making design and modeling hard | |||
**Large outlays of DNA real-estate may be necessary | |||
**Large energetic loads on host state | |||
Latest revision as of 09:52, 6 April 2009
I am a new member of OpenWetWare!
Projects
Electronic counter review
Gemini
Simulation
Computational modeling notebook
Genetic switches: methylation & feedback regulation
Recombination switches
Assorted items of interest
James Ferrell
- Timekeeping (James Ferrell)
- Feedback loops (James Ferrell)
Biological computation
- Arkin: computation in biochemical networks
- Chemical implementation of finite state machine
- Chemical implementation of Turing machine
Basic construction / design principles
- Summary of reviews by
- Voight, Endy, Arkin
Computational modeling to aid design
- Review of
- Collins toggle switch
- Elowitz repressilator
Prior work: implementing recombinase switches
- Ham & Arkin inversion switch
- Harvard/BU 2004 iGem Int/Xis inversion switch & counter
- Their final presentation
- Notes on this work
Challenges
- No spatial addressing of signals in biological systems
- Many heterogeneous parts implemented, resulting in:
- Heterogeneity of device physics across circuits
- Complex properties, making design and modeling hard
- Large outlays of DNA real-estate may be necessary
- Large energetic loads on host state
