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--[[User:LarryGray|LarryGray]] 23: | --[[User:LarryGray|LarryGray]] 23:52, 6 April 2007 (EDT) | ||
"the two ssDNA regions were distributed in trans, suggesting that UV lesions specifically affect only one of the two replication apparatuses (either both leading or both lagging strands)." | ''Lopes et al'' | ||
Question 1: Maureen, Mahti, or Chris. Could you clarify what the author means by 'in trans' in the quote below and how this would suggest that only one replic. apparatus is being affected? Page 16, 20th line from bottom of right colum | |||
"the two ssDNA regions were distributed in trans, suggesting that UV lesions specifically affect | |||
only one of the two replication apparatuses (either both leading or both lagging strands)." | |||
Question 2: More clarification needed. How can the authors conclude from the observation that the distribution of internal gaps along replicated duplexes mirrored the length distribution of replicated strands suggests that discontinuities left randomaly behind the fork are not immediately sealed after the passage of the replication fork? Page 18, last line of left colum. | |||
Revision as of 09:46, 7 April 2007
Lawrence Wilson Gray
Graduate Research Assistant
Department of Biochemistry and Molecular Biology
Contact Info
Email: grayl AT OHSU dot edu
Thesis Projects
- Copper dependent regulation of copper-transporting Atpases
- Identification and characterization of the small molecular weight copper binding component of human urine
Education
Undergraduate Institutions:
Louisiana College Sep 1997 - Dec 1999 Univ Maryland Baltimore Co Jan 2000 - Jun 2000 Fullerton College Jun 2001 - Aug 2001 Caifornia State University, Fullerton Aug 2001 - Jun 2005
Graduate Institution:
Oregon Health & Science University Sep 2005 - Present
Publications
- Gray LW, Kidane TZ, Nguyen A, Akagi S, Petrasek K, Chu Y, Pham TH, Cabrera A, Kantardjieff K, Mason AZ and Linder MC. Multiple copper proteins and Ferro-oxidases in mouse and human plasma. Submitted April 2007
Research Interests
- Metal Metabolism
- Development of Therapeutics for Cholangiolar carcinoma
- Development of Diagnostic Assays for Copper Related diseases
- Inflammation
Some Articles about me:
- http://campusapps.fullerton.edu/news/2005/2_marc.html
- http://campusapps.fullerton.edu/news/research/2004/linder.html
- http://campusapps.fullerton.edu/news/research/2004/print/216_csu_research.html
Questions
Week 2
--LarryGray 23:52, 6 April 2007 (EDT)
Lopes et al
Question 1: Maureen, Mahti, or Chris. Could you clarify what the author means by 'in trans' in the quote below and how this would suggest that only one replic. apparatus is being affected? Page 16, 20th line from bottom of right colum
"the two ssDNA regions were distributed in trans, suggesting that UV lesions specifically affect only one of the two replication apparatuses (either both leading or both lagging strands)."
Question 2: More clarification needed. How can the authors conclude from the observation that the distribution of internal gaps along replicated duplexes mirrored the length distribution of replicated strands suggests that discontinuities left randomaly behind the fork are not immediately sealed after the passage of the replication fork? Page 18, last line of left colum.
