User:Lily Wang: Difference between revisions

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==Contact Info==
==Contact Info==
[[Image:PICT0020.JPG|thumb|right|Lily Wang]]
[[Image:LWgrad.JPG|thumb|right|Lily Wang]]


*Lily Wang
* Lily Wang
*Columbia University
* 10 Discovery Drive
*1130 St. Nicholas Ave.
* Farmington, CT 06032
*ICRC 602
*New York, NY 10032 USA
*[[Special:Emailuser/Lily Wang|Email me through OpenWetWare]]
*[[Special:Emailuser/Lily Wang|Email me through OpenWetWare]]
(Updated 2/9/2017)


I work in the [http://gautier.openwetware.org Gautier Lab] at [http://www.columbia.edu Columbia University].  I learned about [[OpenWetWare]] from the Hoatlin lab [http://openwetware.org/wiki/Hoatlin_Lab], and I've joined in order to contribute to the Gautier Lab site.
I originally created this page when I worked in the [http://gautier.openwetware.org Gautier Lab] at [http://www.columbia.edu Columbia University].  I learned about [[OpenWetWare]] from the [http://openwetware.org/wiki/Hoatlin_Lab Hoatlin Lab], and I joined in order to contribute to the Gautier Lab site.


==Education==
==Education==
<!--Include info about your educational background-->
<!--Include info about your educational background-->
* MD-PhD Student at Columbia University
* 2017-2018, Fellowship in Pediatric Urology, Texas Children's Hospital - Baylor School of Medicine
* 2002, BS Biophysics, Brown University
* 2016-2017, Fellowship in Pediatric Urology, Connecticut Children's Medical Center - University of Connecticut
* 2011-2016, Residency in Urology, New York Presbyterian Hospital - Weill Cornell Medical Center
* 2010-2011, Internship in General Surgery, New York Presbyterian Hospital - Weill Cornell Medical Center
* MD, College of Physicians and Surgeons, Columbia University
* PhD Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University
* BS Biophysics, Brown University


==Current Research Topics==
==Current Research Topics==


Gautier Lab, Columbia University, 2005-present
I am currently in the laboratory of Dr. Jacques Banchereau studying immune system development and the immune microenvironment in urothelial cell bladder cancer using transcriptomics in the Jackson Laboratory for Genomic Medicine.
 
==Previous Research Topics==
[[Image:PICT0020.JPG|thumb|right|Lily Wang]]
http://openwetware.org/wiki/Gautier_Lab:Lily_Wang
 
Laboratory of Lewis Cantley, Weill Cornell Medical Center, 2013-2014
 
* Studying targeted drug therapies including cabozantinib and buparlisib for advanced prostate cancer
 
Laboratory of Jean Gautier, Columbia University, 2005-2009
 
* Studying the role of Fanconi anemia (FA) proteins in DNA replication and repair.  I have been studying the molecular requirements for the recruitment of FA proteins to chromatin during unperturbed DNA replication.  I have also been examining the role of FA proteins in the replication restart and DNA repair.
Laboratory of Giovanni Romeo, Hospital of Bologna, Italy, 2002-2003
 
* Using RET tyrosine kinase mutants found in Hirschsprung's disease and cancer predisposition syndromes, we studied the role of RET in enteric aganglionosis and caspase activation.
 
Sedivy Lab, Brown University, 2000-2002


I am studying the role of Fanconi anemia (FA) proteins in DNA replication and repair.  I have been studying the molecular requirements for the recruitment of FA proteins to chromatin during unperturbed DNA replication.  I have also been examining the role of FA proteins in the replication restart and DNA repair.
* Using the Shokat method, we engineered Raf-1 mutants with a mutated ATP-binding pocket that preferentially used orthogonal ATP analogs.  Using these mutants, we investigated the downstream substrates of Raf-1.


==Publications==
==Publications==
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<biblio>
# '''Wang LC''', Poppas DP. Surgical Outcomes and Complications of Reconstructive Surgery in the Female Congenital Adrenal Hyperplasia Patient: What Every Endocrinologist Should Know. J. Steroid Biochem. Mol. Biol. 1900 Jan 01 [https://www.ncbi.nlm.nih.gov/pubmed/26995108 PubMed] <br>
#Paper1 pmid=14706820
# '''Wang LC''', Al Hussein Al Awamlh B, Hu JC, Laudano MA, Davison WL, Schulster ML, Zhao F, Chughtai B, Lee RK. Trends in Mesh Use for Pelvic Organ Prolapse Repair From the Medicare Database. Urology 2015 Nov [https://www.ncbi.nlm.nih.gov/pubmed/26344153 PubMed] <br>
// leave a comment about a paper here
# Al Hussein Al Awamlh B,'''Wang LC''', Nguyen DP, Rieken M, Lee RK, Lee DJ, Flynn T, Chrystal J, Shariat SF, Scherr DS. Is continent cutaneous urinary diversion a suitable alternative to orthotopic bladder substitute and ileal conduit after cystectomy? BJU Int. 2014 Aug 30 [https://www.ncbi.nlm.nih.gov/pubmed/25168771 PubMed] <br>
</biblio>
# '''Wang LC''', Osterberg EC, David SG, Rosoff JS. Recurrent nephrolithiasis associated with atazanavir use. BMJ Case Rep 2014 [https://www.ncbi.nlm.nih.gov/pubmed/24403382 PubMed] <br>
# '''Wang LC''', Xylinas E, Kent, MT, Kluth, LA, Rink M, Jamzadeh A, Rieken M, Al Awamlh BA, Trinh QD, Sun M, Karakiewicz PI, Novara G, Chrystal J, Zerb... Combining smoking information and molecular markers improves prognostication in patients with urothelial carcinoma of the bladder. Urol. Oncol. 2014 Jan 18
# Srinivasan SV, Dominguez-Sola D, '''Wang LC''', Hyrien O, Gautier J. Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress. Cell Rep 2013 May 30 [https://www.ncbi.nlm.nih.gov/pubmed/24433754 PubMed] <br>
# Stock C, '''Wang LC''', Spigland NA. Untangling a web: an unusual case of labial necrosis in an adolescent female. J Pediatr Adolesc Gynecol 2012 Apr [https://www.ncbi.nlm.nih.gov/pubmed/26995108 PubMed] <br>
# '''Wang LC''', Gautier J. The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol. 2010 pmid=20807115 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20807115 PubMed] <br>  
# Ben-Yehoyada M, '''Wang LC''', Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J. Checkpoint signaling from a single DNA interstrand crosslink. Molecular Cell. 2009 pmid=19748363 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19748363 PubMed] <br>
# '''Wang LC''', Stone S, Hoatlin ME, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair 2008 pmid=18786657 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18786657 PubMed] <br>
# Yin L, Puliti A, Bonora E, Evangelisti C, Conti V, Tong WM, Medard JJ, Lavoué MF, Forey N, '''Wang LC''', Manié S, Morel G, Raccurt M, Wang ZQ, Romeo G. C620R mutation of the murine ret proto-oncogene: loss of function effect in homozygotes and possible gain of function effect in heterozygotes. International Journal of Cancer 2007 pmid=17372903 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17372903 PubMed] <br>
# Hindley AD, Park S, '''Wang L''', Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Letters 2004 pmid=14706820 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14706820 PubMed] <br>


==Useful links==
==Useful links==
*[[OpenWetWare:Welcome|Introductory tutorial]]
*[[OpenWetWare:Welcome|Introductory tutorial]]
*[[Help|OpenWetWare help pages]]
*[[Help|OpenWetWare help pages]]

Latest revision as of 14:53, 9 February 2017

Contact Info

Lily Wang

(Updated 2/9/2017)

I originally created this page when I worked in the Gautier Lab at Columbia University. I learned about OpenWetWare from the Hoatlin Lab, and I joined in order to contribute to the Gautier Lab site.

Education

  • 2017-2018, Fellowship in Pediatric Urology, Texas Children's Hospital - Baylor School of Medicine
  • 2016-2017, Fellowship in Pediatric Urology, Connecticut Children's Medical Center - University of Connecticut
  • 2011-2016, Residency in Urology, New York Presbyterian Hospital - Weill Cornell Medical Center
  • 2010-2011, Internship in General Surgery, New York Presbyterian Hospital - Weill Cornell Medical Center
  • MD, College of Physicians and Surgeons, Columbia University
  • PhD Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University
  • BS Biophysics, Brown University

Current Research Topics

I am currently in the laboratory of Dr. Jacques Banchereau studying immune system development and the immune microenvironment in urothelial cell bladder cancer using transcriptomics in the Jackson Laboratory for Genomic Medicine.

Previous Research Topics

Lily Wang

http://openwetware.org/wiki/Gautier_Lab:Lily_Wang

Laboratory of Lewis Cantley, Weill Cornell Medical Center, 2013-2014

  • Studying targeted drug therapies including cabozantinib and buparlisib for advanced prostate cancer

Laboratory of Jean Gautier, Columbia University, 2005-2009

  • Studying the role of Fanconi anemia (FA) proteins in DNA replication and repair. I have been studying the molecular requirements for the recruitment of FA proteins to chromatin during unperturbed DNA replication. I have also been examining the role of FA proteins in the replication restart and DNA repair.

Laboratory of Giovanni Romeo, Hospital of Bologna, Italy, 2002-2003

  • Using RET tyrosine kinase mutants found in Hirschsprung's disease and cancer predisposition syndromes, we studied the role of RET in enteric aganglionosis and caspase activation.

Sedivy Lab, Brown University, 2000-2002

  • Using the Shokat method, we engineered Raf-1 mutants with a mutated ATP-binding pocket that preferentially used orthogonal ATP analogs. Using these mutants, we investigated the downstream substrates of Raf-1.

Publications

  1. Wang LC, Poppas DP. Surgical Outcomes and Complications of Reconstructive Surgery in the Female Congenital Adrenal Hyperplasia Patient: What Every Endocrinologist Should Know. J. Steroid Biochem. Mol. Biol. 1900 Jan 01 PubMed
  2. Wang LC, Al Hussein Al Awamlh B, Hu JC, Laudano MA, Davison WL, Schulster ML, Zhao F, Chughtai B, Lee RK. Trends in Mesh Use for Pelvic Organ Prolapse Repair From the Medicare Database. Urology 2015 Nov PubMed
  3. Al Hussein Al Awamlh B,Wang LC, Nguyen DP, Rieken M, Lee RK, Lee DJ, Flynn T, Chrystal J, Shariat SF, Scherr DS. Is continent cutaneous urinary diversion a suitable alternative to orthotopic bladder substitute and ileal conduit after cystectomy? BJU Int. 2014 Aug 30 PubMed
  4. Wang LC, Osterberg EC, David SG, Rosoff JS. Recurrent nephrolithiasis associated with atazanavir use. BMJ Case Rep 2014 PubMed
  5. Wang LC, Xylinas E, Kent, MT, Kluth, LA, Rink M, Jamzadeh A, Rieken M, Al Awamlh BA, Trinh QD, Sun M, Karakiewicz PI, Novara G, Chrystal J, Zerb... Combining smoking information and molecular markers improves prognostication in patients with urothelial carcinoma of the bladder. Urol. Oncol. 2014 Jan 18
  6. Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J. Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress. Cell Rep 2013 May 30 PubMed
  7. Stock C, Wang LC, Spigland NA. Untangling a web: an unusual case of labial necrosis in an adolescent female. J Pediatr Adolesc Gynecol 2012 Apr PubMed
  8. Wang LC, Gautier J. The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol. 2010 pmid=20807115 PubMed
  9. Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J. Checkpoint signaling from a single DNA interstrand crosslink. Molecular Cell. 2009 pmid=19748363 PubMed
  10. Wang LC, Stone S, Hoatlin ME, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair 2008 pmid=18786657 PubMed
  11. Yin L, Puliti A, Bonora E, Evangelisti C, Conti V, Tong WM, Medard JJ, Lavoué MF, Forey N, Wang LC, Manié S, Morel G, Raccurt M, Wang ZQ, Romeo G. C620R mutation of the murine ret proto-oncogene: loss of function effect in homozygotes and possible gain of function effect in heterozygotes. International Journal of Cancer 2007 pmid=17372903 PubMed
  12. Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Letters 2004 pmid=14706820 PubMed

Useful links

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