User:Liuzhec

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Project Overview

• Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
• The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
• As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
• We expect that molecular containers could have several interesting scientific and clinical applications, such as
  • Drug and gene delivery
  • Bio-marker scavenging (early detection of biomarkers)
  • Directed evolution (compartmentalized selections)
  • Using multiplexing for combinatorial chemical synthesis
  • Capture and stabilization of multiprotein complexes
  • Protein folding (chaperones)
  • Cell sorting

==Working Team Members== edit

• Tiffany Chan (talk, edits)
• Katherine Fifer (talk, edits)
• Valerie Lau (talk, edits)
• Matthew Meisel (talk, edits)
• Lewis Hahn (talk, edits)
• TA: Shawn Douglas (talk, edits)

Recent Changes

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Welcome to Harvard's 2006 iGEM team wiki! Please click on the project of interest for up to date information and current progress.

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Planning News and Announcements Jamboree Photos Final Presentation Team Background Reading Meetings Lab schedule Personnel schedule Projects Cyanobacteria Notebook Cell Surface Targeting Adaptamers Streptavidin Cell Surface Fusion Protein DNA nanostructures Notebook Project Planning Brainstorming Sign up Past project notes For visitors Weaving Barrels from DNA (11/15/06) Official 2006 Harvard iGEM team page Synthetic Biology Official iGEM page Participating Institutions 2005 Harvard iGEM wiki SynBio Comic NYT article (11/24/05)

In the Lab Protocols Open Wetware Protocols Ligation Protocol Our Own Protocols Lab Notebooks Laboratory Notebooks Useful links iGEM and OWW OpenWetWare Etiquette Other iGEM teams on OWW BioBricks registry Harvard page on iGEM wiki Literature Pubmed for Harvard PIN holders ISI Web of Science Python Dive Into Python Python Tutorial Perl to Python Python Lib Ref Py Reg Ex Miscellaneous Excel → Wiki Table converter Presentation Advice 1 kb+ ladder Buffer and gel tables BioMath calculators (Promega)

People Super Heroes DNA Nanostructures Tiffany Chan (talk) Katherine Fifer (talk) Valerie Lau (talk) Matthew Meisel (talk) Cyanobacteria Hetmann Hsieh (talk) Jeffrey Lau (talk) Zhipeng Sun (talk) David Ramos (talk) Cell surface targeting Perry Tsai (talk) Lewis Hahn (talk) Teaching Fellows Chris Doucette (talk) Shawn Douglas (talk) Nicholas Stroustrup (talk) Advisors Pamela Silver (talk) George Church (talk) Radhika Nagpal Jagesh V. Shah William Shih (talk) Alain Viel

Harvard 2006 iGem team.

Back row (L-R): Lewis, Katie, Tiffany, Valerie, Zhipeng, Matt.
Front row (L-R): Hetmann, Jeffrey, David, Perry.

And yes, that is the back end of a bronze rhinoceros.

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A thanks goes to MIT's team page for our page formatting.