User:Marie-Eve Val: Difference between revisions
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*1999 - '''Technician degree in Biotechnology '''<br/>LVC (Gif-sur-Yvette) | *1999 - '''Technician degree in Biotechnology '''<br/>LVC (Gif-sur-Yvette) | ||
== Professional Training == | == Professional Training == | ||
Revision as of 07:41, 13 December 2011
I am a new member of OpenWetWare!
Contact Info
- Marie-Eve VAL
- Institut Pasteur
- 25 rue du Dr. Roux 75015
- Paris, France
- Email me through OpenWetWare
Education
- 2008 - PhD
Centre de Génétique Moléculaire (Gif-sur-Yvette) , Francois-Xavier Barre's lab
Study of the system of chromosome dimer resolution in Vibrio cholerae and its implication in the control of the lysogeny of the phage CTX coding for the choleric toxin
- 2003 - Engineering degree in biotechnology and Master in cellular and molecular biology
ESBS (Strasbourg, Freiburg, Karlsruhe and Basel)
- 1999 - Technician degree in Biotechnology
LVC (Gif-sur-Yvette)
Professional Training
- Since Jan 2009 - Post-Doctoral research fellow
Didier Mazel's lab, Institut Pasteur, Paris - Sep 2004 / Dec 2008 - PhD Thesis
Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette / Dr. BARRE François-Xavier - Mar / Sep 2004 - Engineer positionGénoscope - Consortium National de Recherche en Génomique - Génolevures Consortium
Jan / Sep 2003 Master thesis Center of Marine Biotechnology, UMBI, Baltimore, Maryland, USA / Dr. SCHREIER Harold J. Topic : “Study of the Regulation of the bacterio-opsin gene expression in the extremely halophilic archaeon Halobacterium NRC-1.” Dec 2002 Engineer internship IGBMC Structural biology and genomics laboratory, Strasbourg / Dr. POCH Olivier Elaboration of a script to find new candidates for a family of proteins using bioinformatics tools Jun / Aug 2001 Engineer internship BIOZENTRUM Applied Microbiology, Basel, Switzerland / Prof. Dr. PHILIPPSEN Peter Construction of N-terminal fusion [Tub1gene-GFP] to visualize microtubules in A. gossypii and S. cerevisiae by fluorescence microscopy. Dec 1999 / Aug 2000 and Jul / Aug 2002 Technician position (CDD) AGROGENE, R&D Department, Moissy-Cramayel Optimization of tests dealing with detection of transgenic plants at the genomic level using real time qPCR, attestation of pre-market products and guidance of interns. Jan / Feb 1999 Technician internship Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette / Dr. BOCCARD Frederic Study of the BIMEs in the regulation of gene expression in E.coli
Research interests
I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome. This genetic tool consists in harnessing the λ and HK022 recombination systems to perform a large panel of genome reorganizations. By controlling the location and the orientation of each partner recombination site, we can obtain a large variety of genome rearrangements. The laboratory of Didier Mazel was an ideal place to initiate such a project since they have developed a large set of genetic tools to work in the vibrios and Didier Mazel has substantial knowledge and experience in site-specific recombination, bacterial genetics and genome analysis.
Publications
- Das B, Bischerour J, Val ME, and Barre FX. Molecular keys of the tropism of integration of the cholera toxin phage. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4377-82. DOI:10.1073/pnas.0910212107 |
Molecular keys of the tropism of integration of the cholera toxin phage.
- Génolevures Consortium, Souciet JL, Dujon B, Gaillardin C, Johnston M, Baret PV, Cliften P, Sherman DJ, Weissenbach J, Westhof E, Wincker P, Jubin C, Poulain J, Barbe V, Ségurens B, Artiguenave F, Anthouard V, Vacherie B, Val ME, Fulton RS, Minx P, Wilson R, Durrens P, Jean G, Marck C, Martin T, Nikolski M, Rolland T, Seret ML, Casarégola S, Despons L, Fairhead C, Fischer G, Lafontaine I, Leh V, Lemaire M, de Montigny J, Neuvéglise C, Thierry A, Blanc-Lenfle I, Bleykasten C, Diffels J, Fritsch E, Frangeul L, Goëffon A, Jauniaux N, Kachouri-Lafond R, Payen C, Potier S, Pribylova L, Ozanne C, Richard GF, Sacerdot C, Straub ML, and Talla E. Comparative genomics of protoploid Saccharomycetaceae. Genome Res. 2009 Oct;19(10):1696-709. DOI:10.1101/gr.091546.109 |
Comparative genomics of protoploid Saccharomycetaceae.
- Val ME, Kennedy SP, El Karoui M, Bonné L, Chevalier F, and Barre FX. FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae. PLoS Genet. 2008 Sep 26;4(9):e1000201. DOI:10.1371/journal.pgen.1000201 |
FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae.
- Val ME, Bouvier M, Campos J, Sherratt D, Cornet F, Mazel D, and Barre FX. The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae. Mol Cell. 2005 Aug 19;19(4):559-66. DOI:10.1016/j.molcel.2005.07.002 |
The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.
