User:Marie-Eve Val: Difference between revisions
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[[Image: | [[Image:Marie-Eve.jpg|300px|thumb|right||border]] | ||
[[Image: | [[Image:Vibriohealthy.jpg|400px|thumb|Vibrio cholerae|border]] | ||
[[Image:fusion.jpg| | [[Image:fusion.jpg|600px|thumb|right|site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome|border]] | ||
<font size="3">'''Marie-Eve VAL'''<br/><font size="2">INSTITUT PASTEUR<br/>Unité "Plasticité du Génome Bactérien"<br/>Département Génomes et Génétique<br/>CNRS URA2171<br/>25 rue du Dr. Roux<br/> | [[Image:MCH1chrrec.jpg|400px|thumb|Genome rearrangement events occuring within a single colony|border]] | ||
<font size="3">'''Marie-Eve VAL'''</font size><br/><font size="2">INSTITUT PASTEUR<br/>Unité "Plasticité du Génome Bactérien"<br/>Département Génomes et Génétique<br/>CNRS URA2171<br/>25 rue du Dr. Roux<br/> | |||
75724 PARIS cedex 15<br/>FRANCE<br/>[[Special:Emailuser/Marie-Eve_Val|Email me through OpenWetWare]] | 75724 PARIS cedex 15<br/>FRANCE<br/>[[Special:Emailuser/Marie-Eve_Val|Email me through OpenWetWare]] | ||
==Research interests== | ==Research interests== | ||
<!-- Feel free to add brief descriptions to your research interests as well --> | <!-- Feel free to add brief descriptions to your research interests as well --> | ||
I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome | I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome. The laboratory of Didier Mazel was an ideal place to initiate such a project since they have developed a large set of genetic tools to work in the vibrios and Didier Mazel has substantial knowledge and experience in site-specific recombination, bacterial genetics and genome analysis. | ||
==Education== | ==Education== | ||
<!--Include info about your educational background--> | <!--Include info about your educational background--> | ||
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*2003 - '''Engineering degree in biotechnology and Master in cellular and molecular biology''' <br/>[http://www-esbs.u-strasbg.fr/esbs/?lang=en ESBS (Strasbourg, Freiburg, Karlsruhe and Basel)] | *2003 - '''Engineering degree in biotechnology and Master in cellular and molecular biology''' <br/>[http://www-esbs.u-strasbg.fr/esbs/?lang=en ESBS (Strasbourg, Freiburg, Karlsruhe and Basel)] | ||
*1999 - '''Technician degree in Biotechnology '''<br/>LVC (Gif-sur-Yvette) | *1999 - '''Technician degree in Biotechnology '''<br/>LVC (Gif-sur-Yvette) | ||
== Professional Training == | ==Professional Training== | ||
* Since 2009 - '''Post-Doctoral research training'''<br/> [http://www.pasteur.fr/ip/easysite/pasteur/fr Institut Pasteur (Paris)] - [[Mazel| Didier Mazel's lab]]<br/> | * Since 2009 - '''Post-Doctoral research training'''<br/> [http://www.pasteur.fr/ip/easysite/pasteur/fr Institut Pasteur (Paris)] - [[Mazel| Didier Mazel's lab]]<br/> | ||
* 2004 / 2008 - '''PhD Thesis'''<br/>[http://www.cgm.cnrs-gif.fr/version_gb/index_gb.html Centre de Génétique Moléculaire (Gif-sur-Yvette)] , [http://www.cgm.cnrs-gif.fr/barre/index_gb.html Francois-Xavier Barre's lab]<br/> | * 2004 / 2008 - '''PhD Thesis'''<br/>[http://www.cgm.cnrs-gif.fr/version_gb/index_gb.html Centre de Génétique Moléculaire (Gif-sur-Yvette)] , [http://www.cgm.cnrs-gif.fr/barre/index_gb.html Francois-Xavier Barre's lab]<br/> | ||
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<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | <!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | ||
<biblio> | <biblio> | ||
# | # PLOS-Genetics-2012 pmid=22253612 | ||
// Molecular keys of the tropism of integration of the cholera toxin phage | // Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues | ||
# | # PNAS-2010 pmid=20133778 | ||
// Comparative genomics of protoploid Saccharomycetaceae | // Molecular keys of the tropism of integration of the cholera toxin phage | ||
# | # Genome-Research-2009 pmid=19525356 | ||
// FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae | // Comparative genomics of protoploid Saccharomycetaceae | ||
# | # PLOS-Genetics-2008 pmid=18818731 | ||
// The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae | // FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae | ||
# Molecular-Cell-2005 pmid=16109379 | |||
// The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae | |||
</biblio> | </biblio> | ||
Revision as of 06:52, 20 July 2012
Marie-Eve VAL
INSTITUT PASTEUR
Unité "Plasticité du Génome Bactérien"
Département Génomes et Génétique
CNRS URA2171
25 rue du Dr. Roux
75724 PARIS cedex 15
FRANCE
Email me through OpenWetWare
Research interests
I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome. The laboratory of Didier Mazel was an ideal place to initiate such a project since they have developed a large set of genetic tools to work in the vibrios and Didier Mazel has substantial knowledge and experience in site-specific recombination, bacterial genetics and genome analysis.
Education
- 2008 - PhD
Centre de Génétique Moléculaire (Gif-sur-Yvette) , Francois-Xavier Barre's lab
Study of the system of chromosome dimer resolution in Vibrio cholerae and its implication in the control of the lysogeny of the phage CTX coding for the choleric toxin - 2003 - Engineering degree in biotechnology and Master in cellular and molecular biology
ESBS (Strasbourg, Freiburg, Karlsruhe and Basel) - 1999 - Technician degree in Biotechnology
LVC (Gif-sur-Yvette)
Professional Training
- Since 2009 - Post-Doctoral research training
Institut Pasteur (Paris) - Didier Mazel's lab - 2004 / 2008 - PhD Thesis
Centre de Génétique Moléculaire (Gif-sur-Yvette) , Francois-Xavier Barre's lab - 2004 - Engineer position
Génoscope - Consortium National de Recherche en Génomique (Evry) - Génolevures Consortium - 2003 - Master thesis
Center of Marine Biotechnology, UMBI (Baltimore) , Hal Schreier's lab - 2002 - Engineer training
IGBMC (Strasbourg) - Olivier POCH's lab - 2001 - Engineer training
Biozentrum (Basel) - Peter Philippsen's lab - 1999 / 2000 and summer 2002 - Technician position
AGROGENE(Moissy-Cramayel) - 1999 - Technician training
Centre de Génétique Moléculaire (Gif-sur-Yvette) ,Fred Boccard's lab
Publications
- Val ME, Skovgaard O, Ducos-Galand M, Bland MJ, and Mazel D. Genome engineering in Vibrio cholerae: a feasible approach to address biological issues. PLoS Genet. 2012 Jan;8(1):e1002472. DOI:10.1371/journal.pgen.1002472 |
Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues
- Das B, Bischerour J, Val ME, and Barre FX. Molecular keys of the tropism of integration of the cholera toxin phage. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4377-82. DOI:10.1073/pnas.0910212107 |
Molecular keys of the tropism of integration of the cholera toxin phage
- Génolevures Consortium, Souciet JL, Dujon B, Gaillardin C, Johnston M, Baret PV, Cliften P, Sherman DJ, Weissenbach J, Westhof E, Wincker P, Jubin C, Poulain J, Barbe V, Ségurens B, Artiguenave F, Anthouard V, Vacherie B, Val ME, Fulton RS, Minx P, Wilson R, Durrens P, Jean G, Marck C, Martin T, Nikolski M, Rolland T, Seret ML, Casarégola S, Despons L, Fairhead C, Fischer G, Lafontaine I, Leh V, Lemaire M, de Montigny J, Neuvéglise C, Thierry A, Blanc-Lenfle I, Bleykasten C, Diffels J, Fritsch E, Frangeul L, Goëffon A, Jauniaux N, Kachouri-Lafond R, Payen C, Potier S, Pribylova L, Ozanne C, Richard GF, Sacerdot C, Straub ML, and Talla E. Comparative genomics of protoploid Saccharomycetaceae. Genome Res. 2009 Oct;19(10):1696-709. DOI:10.1101/gr.091546.109 |
Comparative genomics of protoploid Saccharomycetaceae
- Val ME, Kennedy SP, El Karoui M, Bonné L, Chevalier F, and Barre FX. FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae. PLoS Genet. 2008 Sep 26;4(9):e1000201. DOI:10.1371/journal.pgen.1000201 |
FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae
- Val ME, Bouvier M, Campos J, Sherratt D, Cornet F, Mazel D, and Barre FX. The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae. Mol Cell. 2005 Aug 19;19(4):559-66. DOI:10.1016/j.molcel.2005.07.002 |
The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae
