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[[Image:Marie-Eve.jpg|300px|thumb|right||border]]
 
[[Image:Vibriohealthy.jpg|400px|thumb|Vibrio cholerae|border]]
==Contact Info==
[[Image:fusion.jpg|600px|thumb|right|site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome|border]]
[[Image:OWWEmblem.png|thumb|right|Marie-Eve Val (an artistic interpretation)]]
[[Image:MCH1chrrec.jpg|400px|thumb|Genome rearrangement events occuring within a single colony|border]]
 
<font size="3">'''Marie-Eve VAL'''</font size><br/><font size="2">INSTITUT PASTEUR<br/>Unité "Plasticité du Génome Bactérien"<br/>Département  Génomes et Génétique<br/>CNRS UMR3525<br/>28 rue du Dr. Roux<br/>
*Marie-Eve VAL
75724 PARIS cedex 15<br/>FRANCE<br/>[[Special:Emailuser/Marie-Eve_Val|Email me through OpenWetWare]]
*Institut Pasteur
==Research interests==
*25 rue du Dr. Roux 75015
<!-- Feel free to add brief descriptions to your research interests as well -->
*Paris, France
I am a research associate in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, we developed a site-specific recombination-based engineering tool, which provides us with a powerful mean to massively reorganize in principle any prokaryotic genome.
*[[Special:Emailuser/Marie-Eve_Val|Email me through OpenWetWare]]
 
==Education==
==Education==
<!--Include info about your educational background-->
<!--Include info about your educational background-->
*2008 - '''PhD''' <br/>
*2008 - '''PhD''' <br/>[http://www.cgm.cnrs-gif.fr/version_gb/index_gb.html Centre de Génétique Moléculaire (Gif-sur-Yvette)] , [http://www.cgm.cnrs-gif.fr/barre/index_gb.html Francois-Xavier Barre's lab]<br/>''Study of the system of chromosome dimer resolution in Vibrio cholerae and its implication in the control of the lysogeny of the phage CTX coding for the choleric toxin''
[http://www.cgm.cnrs-gif.fr/version_gb/index_gb.html Centre de Génétique Moléculaire]<br/>
*2003 - '''Engineering degree in biotechnology and Master in cellular and molecular biology''' <br/>[http://www-esbs.u-strasbg.fr/esbs/?lang=en ESBS (Strasbourg, Freiburg, Karlsruhe and Basel)]
[http://www.cgm.cnrs-gif.fr/barre/index_gb.html Francois-Xavier Barre's lab]<br/>
*1999 - '''BS in Biotechnology '''<br/>LVC (Gif-sur-Yvette)
Study of the system of chromosome dimer resolution in Vibrio cholerae and its implication in the control of the lysogeny of the phage CTX coding for the choleric toxin
==Professional Training==
 
* Since 2013 - '''INSERM Research Associate'''<br/> [http://www.pasteur.fr/ip/easysite/pasteur/fr Institut Pasteur (Paris)] - [[Mazel| Didier Mazel's lab]]<br/>
 
* 2009 / 2013 - '''Post-Doctoral research fellow'''<br/> [http://www.pasteur.fr/ip/easysite/pasteur/fr Institut Pasteur (Paris)] - [[Mazel| Didier Mazel's lab]]<br/>
2003 - '''Engineering degree in biotechnology - Master in cellular and molecular biology''' -'' ''[[ESBS]]'' – Tri-national “Ecole d’ingénieur” in Biotechnology (Strasbourg, Freiburg, Karlsruhe and Basel).''
* 2004 / 2008 - '''PhD Thesis'''<br/>[http://www.cgm.cnrs-gif.fr/version_gb/index_gb.html Centre de Génétique Moléculaire (Gif-sur-Yvette)] , [http://www.cgm.cnrs-gif.fr/barre/index_gb.html Francois-Xavier Barre's lab]<br/>
 
* 2004 - '''Engineer position'''<br/>[http://www.genoscope.cns.fr/spip/spip.php?lang=en Génoscope - Consortium National de Recherche en Génomique (Evry)] - Génolevures Consortium<br/>
1999 '''Technician degree in Biotechnology '''- ''LVC, Gif-sur-Yvette.
* 2003 - '''Master thesis'''<br/>[http://imet.usmd.edu/ Center of Marine Biotechnology, UMBI (Baltimore)] , [http://imet.usmd.edu/people/schreier.html Hal Schreier's lab]<br/>
''
* 2002 - '''Engineer training'''<br/>[http://www.igbmc.fr/recherche/plateformes/bioinfo/index.html IGBMC (Strasbourg) - Olivier POCH's lab]<br/>
 
* 2001 - '''Engineer training'''<br/>[http://www.biozentrum.unibas.ch/ Biozentrum (Basel) - Peter Philippsen's lab]<br/>
==Research interests==
* 1999 / 2000 and summer 2002 - '''Technician position'''<br/>AGROGENE(Moissy-Cramayel)<br/>
<!-- Feel free to add brief descriptions to your research interests as well -->
* 1999 - '''Internship'''<br/>[http://www.cgm.cnrs-gif.fr/version_gb/index_gb.html Centre de Génétique Moléculaire (Gif-sur-Yvette)] ,[http://www.cgm.cnrs-gif.fr/coli/index.html Fred Boccard's lab]<br/>
I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome. This genetic tool consists in harnessing the λ and HK022 recombination systems to perform a large panel of genome reorganizations. By controlling the location and the orientation of each partner recombination site, we can obtain a large variety of genome rearrangements. The laboratory of Didier Mazel was an ideal place to initiate such a project since they have developed a large set of genetic tools to work in the vibrios and Didier Mazel has substantial knowledge and experience in site-specific recombination, bacterial genetics and genome analysis.


==Publications==
==Publications==
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
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<biblio>
<biblio>
#Paper1 pmid=20133778  
# Science-Advances-2016 pmid=27152358
// Molecular keys of the tropism of integration of the cholera toxin phage.
// A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae
#Paper2 pmid=19525356
# PLoS-Genet-2015 pmid=25875621
// Comparative genomics of protoploid Saccharomycetaceae.
// Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity
#Paper3 pmid=18818731  
# Curr-Opin-Microbiol-2014 pmid=25460805
// FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae.
// Management of multipartite genomes: the Vibrio cholerae model
#Paper4 pmid=16109379  
# Molecular-Microbioloy-2014 pmid=24308271
// The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.
// Fuse or die: how to survive the loss of Dam in Vibrio cholerae
 
# PLOS-Genetics-2012 pmid=22253612
// Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues
# PNAS-2010 pmid=20133778  
// Molecular keys of the tropism of integration of the cholera toxin phage
# Genome-Research-2009 pmid=19525356
// Comparative genomics of protoploid Saccharomycetaceae  
# PLOS-Genetics-2008 pmid=18818731  
// FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae
# Molecular-Cell-2005 pmid=16109379
// The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae
</biblio>
</biblio>


Latest revision as of 04:07, 3 June 2016

Vibrio cholerae
site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome
Genome rearrangement events occuring within a single colony

Marie-Eve VAL
INSTITUT PASTEUR
Unité "Plasticité du Génome Bactérien"
Département Génomes et Génétique
CNRS UMR3525
28 rue du Dr. Roux
75724 PARIS cedex 15
FRANCE
Email me through OpenWetWare

Research interests

I am a research associate in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, we developed a site-specific recombination-based engineering tool, which provides us with a powerful mean to massively reorganize in principle any prokaryotic genome.

Education

Professional Training

Publications

  1. Val ME, Marbouty M, de Lemos Martins F, Kennedy SP, Kemble H, Bland MJ, Possoz C, Koszul R, Skovgaard O, and Mazel D. A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae. Sci Adv. 2016 Apr;2(4):e1501914. DOI:10.1126/sciadv.1501914 | PubMed ID:27152358 | HubMed [Science-Advances-2016]

    A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae

  2. Soler-Bistué A, Mondotte JA, Bland MJ, Val ME, Saleh MC, and Mazel D. Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity. PLoS Genet. 2015 Apr;11(4):e1005156. DOI:10.1371/journal.pgen.1005156 | PubMed ID:25875621 | HubMed [PLoS-Genet-2015]

    Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity

  3. Val ME, Soler-Bistué A, Bland MJ, and Mazel D. Management of multipartite genomes: the Vibrio cholerae model. Curr Opin Microbiol. 2014 Dec;22:120-6. DOI:10.1016/j.mib.2014.10.003 | PubMed ID:25460805 | HubMed [Curr-Opin-Microbiol-2014]

    Management of multipartite genomes: the Vibrio cholerae model

  4. Val ME, Kennedy SP, Soler-Bistué AJ, Barbe V, Bouchier C, Ducos-Galand M, Skovgaard O, and Mazel D. Fuse or die: how to survive the loss of Dam in Vibrio cholerae. Mol Microbiol. 2014 Feb;91(4):665-78. DOI:10.1111/mmi.12483 | PubMed ID:24308271 | HubMed [Molecular-Microbioloy-2014]

    Fuse or die: how to survive the loss of Dam in Vibrio cholerae

  5. Val ME, Skovgaard O, Ducos-Galand M, Bland MJ, and Mazel D. Genome engineering in Vibrio cholerae: a feasible approach to address biological issues. PLoS Genet. 2012 Jan;8(1):e1002472. DOI:10.1371/journal.pgen.1002472 | PubMed ID:22253612 | HubMed [PLOS-Genetics-2012]

    Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues

  6. Das B, Bischerour J, Val ME, and Barre FX. Molecular keys of the tropism of integration of the cholera toxin phage. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4377-82. DOI:10.1073/pnas.0910212107 | PubMed ID:20133778 | HubMed [PNAS-2010]

    Molecular keys of the tropism of integration of the cholera toxin phage

  7. Génolevures Consortium, Souciet JL, Dujon B, Gaillardin C, Johnston M, Baret PV, Cliften P, Sherman DJ, Weissenbach J, Westhof E, Wincker P, Jubin C, Poulain J, Barbe V, Ségurens B, Artiguenave F, Anthouard V, Vacherie B, Val ME, Fulton RS, Minx P, Wilson R, Durrens P, Jean G, Marck C, Martin T, Nikolski M, Rolland T, Seret ML, Casarégola S, Despons L, Fairhead C, Fischer G, Lafontaine I, Leh V, Lemaire M, de Montigny J, Neuvéglise C, Thierry A, Blanc-Lenfle I, Bleykasten C, Diffels J, Fritsch E, Frangeul L, Goëffon A, Jauniaux N, Kachouri-Lafond R, Payen C, Potier S, Pribylova L, Ozanne C, Richard GF, Sacerdot C, Straub ML, and Talla E. Comparative genomics of protoploid Saccharomycetaceae. Genome Res. 2009 Oct;19(10):1696-709. DOI:10.1101/gr.091546.109 | PubMed ID:19525356 | HubMed [Genome-Research-2009]

    Comparative genomics of protoploid Saccharomycetaceae

  8. Val ME, Kennedy SP, El Karoui M, Bonné L, Chevalier F, and Barre FX. FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae. PLoS Genet. 2008 Sep 26;4(9):e1000201. DOI:10.1371/journal.pgen.1000201 | PubMed ID:18818731 | HubMed [PLOS-Genetics-2008]

    FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae

  9. Val ME, Bouvier M, Campos J, Sherratt D, Cornet F, Mazel D, and Barre FX. The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae. Mol Cell. 2005 Aug 19;19(4):559-66. DOI:10.1016/j.molcel.2005.07.002 | PubMed ID:16109379 | HubMed [Molecular-Cell-2005]

    The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae

All Medline abstracts: PubMed | HubMed

Useful links

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