User:Marie-Eve Val

From OpenWetWare

Revision as of 11:29, 13 December 2011 by Marie-Eve Val (Talk | contribs)
Jump to: navigation, search
Vibrio cholerae
Vibrio cholerae
Vibrio cholerae with big segregation problems
Vibrio cholerae with big segregation problems

Marie-Eve VAL
Unité "Plasticité du Génome Bactérien"
Département Génomes et Génétique
25 rue du Dr. Roux
75724 PARIS cedex 15
Email me through OpenWetWare


Research interests

I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome. This genetic tool consists in harnessing the λ and HK022 recombination systems to perform a large panel of genome reorganizations. By controlling the location and the orientation of each partner recombination site, we can obtain a large variety of genome rearrangements. The laboratory of Didier Mazel was an ideal place to initiate such a project since they have developed a large set of genetic tools to work in the vibrios and Didier Mazel has substantial knowledge and experience in site-specific recombination, bacterial genetics and genome analysis.


Professional Training


Error fetching PMID 20133778:
Error fetching PMID 19525356:
Error fetching PMID 18818731:
Error fetching PMID 16109379:
  1. Error fetching PMID 20133778: [Paper1]
    Molecular keys of the tropism of integration of the cholera toxin phage.

  2. Error fetching PMID 19525356: [Paper2]
    Comparative genomics of protoploid Saccharomycetaceae.

  3. Error fetching PMID 18818731: [Paper3]
    FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae.

  4. Error fetching PMID 16109379: [Paper4]
    The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.

All Medline abstracts: PubMed HubMed

Useful links

Personal tools