User:Mark Blenner
Mark Blenner
Immune Disease Institute
Harvard Medical School
Timothy Springer's Lab
3 Blackfan Circle
Boston, MA 02115
blenner@idi.harvard.edu
Previously, I worked in the Banta Lab at Columbia University.
Currently, I am a Research Fellow in the Springer Lab at the Immune Disease Institute affiliated with Harvard Medical School and Children's Hospital.
Education
- 2009, PhD, Columbia University (Chemical Engineering)
- 2007, MS, Columbia University (Chemical Engineering)
- 2004, BS, Manhattan College (Chemical Engineering)
Research interests
My research interests involve studying protein conformational change. Using a combination of biochemical, biophysical and single-molecule techniques, we can begin to understand the complex ways in which proteins are able to regulate their properties. Using protein engineering tools, such as directed evolution and other high throughput technologies, we can better understand protein conformational changes, as well as conformational dynamics. This work sheds new light on biological function and pathological dysfunction. This knowledge and these tools are used to design advanced biotechnologies addressing problems in medicine, biosensing and nanotechnology.
- Protein Engineering
- Conformational Control of Protein Activity
- Biological Conformational Switches
- Directed Evolution & High Throughput Technologies
- Single-molecule Biophysics
- Structural Biology
Publications
<biblio>
- Paper1 Blenner, M., Shur, O., Szilvay, G., Cropeck, D., Banta, S., Calcium induced folding of a Repeat in Toxin (RTX)- Domain Via C-Terminal Entropic Stabilization Under Review.
- Paper2 Szilvay, G., Blenner, M., Cropeck, D., Banta, S. A FRET-based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase Under Review.
- Paper3 pmid=18218715
- Paper4 pmid=17376876
