User:Mattias Rantalainen

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I'm currently a PhD candidate in the department of Biomolecular Medicine at Imperial College London (UK) in Prof. Elaine Holmes lab, my co-supervisors are Prof. Jeremy Nicholson (Imperial College) and Johan Trygg (Umeå University).
I'm currently a PhD candidate in the department of Biomolecular Medicine at Imperial College London (UK) in Prof. Elaine Holmes lab, my co-supervisors are Prof. Jeremy Nicholson (Imperial College) and Johan Trygg (Umeå University).
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[[Image:Ranta.jpg|frame|]]
[[Image:Ranta.jpg|frame|]]
My PhD research activities are in the area of Metabolite profiling, Chemometrics and Statistical Pattern Analysis, with a focus on development and application of statistical pattern recognition methods for the analysis of ‘Omics’ data in biology, e.g. transcriptomics, proteomics and metabonomics.  
My PhD research activities are in the area of Metabolite profiling, Chemometrics and Statistical Pattern Analysis, with a focus on development and application of statistical pattern recognition methods for the analysis of ‘Omics’ data in biology, e.g. transcriptomics, proteomics and metabonomics.  
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==Science==
I have a general interest in supervised learning and statistical data analysis methods, with a focus on modeling of biological data. I'm particularly interested in methods and strategies for data integration and quantitative approaches to biological research in general.
I have a general interest in supervised learning and statistical data analysis methods, with a focus on modeling of biological data. I'm particularly interested in methods and strategies for data integration and quantitative approaches to biological research in general.
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Recent research activities include:
Recent research activities include:
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Other things I'm interested in:
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Other science topic I'm interested in:
* Statistical Experimental Design
* Statistical Experimental Design
* Automation and standardization of experimental biology including data analysis and representation of biological data
* Automation and standardization of experimental biology including data analysis and representation of biological data

Revision as of 17:07, 13 March 2007

Hello!

I'm currently a PhD candidate in the department of Biomolecular Medicine at Imperial College London (UK) in Prof. Elaine Holmes lab, my co-supervisors are Prof. Jeremy Nicholson (Imperial College) and Johan Trygg (Umeå University).


My PhD research activities are in the area of Metabolite profiling, Chemometrics and Statistical Pattern Analysis, with a focus on development and application of statistical pattern recognition methods for the analysis of ‘Omics’ data in biology, e.g. transcriptomics, proteomics and metabonomics.


Science

I have a general interest in supervised learning and statistical data analysis methods, with a focus on modeling of biological data. I'm particularly interested in methods and strategies for data integration and quantitative approaches to biological research in general.


Recent research activities include:

  • Discriminant analysis
  • Kernel based methods for pattern analysis
  • Integrated modeling of data from multiple analytical platforms
  • Modeling of short time series data sets


Other science topic I'm interested in:

  • Statistical Experimental Design
  • Automation and standardization of experimental biology including data analysis and representation of biological data
  • Synthetic biology
  • Open source / access to software and information


Publications

  • Bylesjö M§, Rantalainen M§, Cloarec O, Nicholson J K, Holmes E, Trygg J. OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification. J Chemometrics, 2007

§Equal contribution

  • Rantalainen, M.; Cloarec, O.; Beckonert, O.; Wilson, I. D.; Jackson, D.; Tonge, R.; Rowlinson, R.; Rayner, S.; Nickson, J.; Wilkinson, R. W.; Mills, J. D.; Trygg, J.; Nicholson, J. K.; Holmes, E. J,Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice, Proteome Res 2006, 5, 2642-2655.
  • R. E. Williams, E. M. Lenz, M. Rantalainen, I. D. Wilson, The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats, Mol. BioSyst., 2006, (3-4),193-202
  • R. E. Williams, E. M. Lenz, J. S. Lowden, M. Rantalainen, I. D. Wilson, The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS, Mol. Biosyst., 2005, (2),166-175


Contact details

Mattias Rantalainen

Department of Biomolecular Medicine
Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA)
Faculty of Medicine >br> Imperial College of Sciences, Technology and Medicine
Sir Alexander Fleming Building
Exhibition Road
South Kensington
London SW7 2AZ

mattias dot rantalainen at imperial dot ac dot uk

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