User:Maureen McKeague
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Contact Info
Maureen McKeague
Stanford University
Shriram Center, Room 256
Mail Code 4245
443 Via Ortega
Stanford, CA 94305
Email me through OpenWetWare
I work in the Smolke lab
Education
- 2007-2012: PhD in Chemistry,Carleton University in the DeRosa lab
- 2003-2007: BSc in Biochemistry and Biotechnology, Carleton University
Research interests
I am passionate about improving human health and quality of life using functional nucleic acids. Specifically, my past, current & future research aims to improve the selection and characterization of small molecule-binding aptamers and ribozymes towards the ultimate goal of developing both in vitro and in vivo biosensors for high-throughput drug screening and disease diagnosis.
Publications
- McKeague, M.; McConnell, E.M.; Cruz-Toledo, J.; Bernard, E.D.; Pach, A.; Zhang, X.; Beking, M.; Francis, T.; Giamberardino, A.; Cabecinha, A.; Ruscito, A.; Aranda-Rodriguez, R.; Dumontier, M.; DeRosa, M.C. Analysis of In Vitro Aptamer Selection Parameters. J Mol Evol. 2015
- Frost, N.R.; McKeague, M.; Falcioni, D.; DeRosa, M.C. An in Solution Assay For Parallel Interrogation of Structure and Affinity of Small Molecule-Binding Aptamers, Analyst 2015, 140, 8, 6643–6651.
- McKeague, M.; De Girolamo, A.; Valenzano, S.; Pascale, M.; Ruscito, A.; Ranganathan, V.; Frost, N.; Hill, K.; Smith, M.; McConnell, E.; DeRosa, M.C.Comprehensive Analytical Comparison of Strategies Used for Small Molecule Aptamer Evaluation, Analytical Chemistry, 2015, 87 (17), 8608–8612.
- Chang, A.L.; McKeague, M.; Smolke, C.D. Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance In: Burke-Aguero, D., editor. Methods in Enzymology. 2014, 549, 451-466.
- McKeague, M.; DeRosa, M.C. Aptamers and SELEX: Tools for the Development of Transformative Molecular Recognition Technology, Aptamers and Synthetic Antibodies, 2014, 1 (1), 12-16.
- McKeague, M.; Ranganathan, V.; Hill, K.; Bardozy, V.; Mezaros, T.; DeRosa, M.C. Selection and Characterization of a Novel DNA Aptamer For Label-Free Fluorescence Biosensing of Ochratoxin A, Toxins, 2014, 6 (8), 2435-2452.
- Chang A.L.; McKeague, M.; Liang, J.C.; Smolke, C.D. Kinetic and Equilibrium Binding Characterization of Aptamers to Small Molecules using a Label-Free, Sensitive, and Scalable Platform, Analytical Chemistry, 2014, 86 (7), 3273–3278.
- Mastronardi, E.; McKeague, M.; Monreal, C.; DeRosa, M.C. Development and Application of Crop Exudate Specific Aptamers, Journal of Biomolecular Structure and Dynamics, 2013, 31 (1), 89.
- McKeague, M.; Foster, A.; Miguel, Y.; Giamberardino, A.; Verdin, C.; Chan, J.Y.; DeRosa, M.C. Development of a DNA aptamer for direct and selective homocysteine detection in human serum, RSC Advances, 2013, 3 (46), 24415-24422.
- McKeague, M.; DeRosa, M.C. Challenges and Opportunities for Small Molecule Aptamer Development, Journal of Nucleic Acids, 2012.
- Cruz-Toledo, J.; McKeague, M.; Zhang, X.; Giamberardino, A.; McConnell, E.; Francis, T.; DeRosa, M.C.; Dumontier, M. Aptamer Base: A collaborative knowledge base to describe aptamers and SELEX experiments. Database: Journal of Biological Databases and Curation. 2012.
- McKeague, M.; Giamberardino, A.; DeRosa, M.C. Advances in Aptamer-Based Biosensors for Food Safety, Environmental Biosensors. 2011, Vernon Somerset (Ed.) ISBN: 9789533074863, InTech. DOI:10.5772/22350
- De Girolamo, A.; McKeague, M.; Miller, J.D.; DeRosa, M.C.; Visconti, A. Determination of Ochratoxin A in Wheat After Clean-Up through a DNA Aptamer-Based Solid Phase Extraction Column. Food Chem. 2011, 127 (3), 1378-1384.
- McKeague, M.; Bradley, C.R.; De Girolamo, A.; Visconti, A.; Miller, J.D.; Derosa, M.C. Screening and Initial Binding Assessment of Fumonisin B(1) Aptamers, Int. J. Mol. Sci. 2010, 11 (12), 4864-4881.
- Luo, X.; McKeague, M.; Pitre, S.; Dumontier, M.; Green, J.; Golshani, A.; Derosa, M.C.; Dehne, F. Computational Approaches Toward the Design of Pools for the in Vitro Selection of Complex Aptamers, RNA. 2010, 16 (11), 2252-2262.
Useful links
- Dance Your PhD 2010 SELEX Dance
- My LinkedIn profile
- Full curriculum vitae
- Interview with the Oligonucleotide Therapeutics Society
- International Society on Aptamers
- Building a search engine for aptamers! Aptamer Base
- 2015 Analytical Chemistry LiveSlides