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{{Odom}}
 
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<font size="3">Michael D. Wilson, PhD</font size><br>
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<font size="3">[http://www.sickkids.ca/AboutSickKids/Directory/People/W/Mike-Wilson-staff-profile.html Michael D. Wilson, PhD</font size><br>]
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Clare Hall Research Fellow<br>
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Scientist<br>
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University of Cambridge<br>
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Genetics & Genome Biology Program<br>
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<font size="2">Cancer Research UK - Cambridge Research Institute<br>
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SickKids, Research Institute<br>
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Li Ka Shing Centre<br>
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<font size="2">Genetics & Genome Biology Program<br>
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Robinson Way, Cambridge,<br>
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101 College St. East Tower | Suite 15-306<br>
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CB2 0RE<br>
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SickKids, Research Institute <br>
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phone:01223404502<br>
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Toronto, Ontario, Canada<br>
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email: michael.wilson ^at^ cancer ^dot^ org ^uk^<br>
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M5G 1L7<br>
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phone:416.813.7654 | Ext. 28699 <br>
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email: michael.wilson ^at^ sickkids ^dot^ ca <br>
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[http://www.sickkids.ca/AboutSickKids/Directory/People/W/Mike-Wilson-staff-profile.html Official SickKids webpage]<br>
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[http://www.moleculargenetics.utoronto.ca/facultyresearch.htm U of T faculty page]<br>
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[http://www.wilsonlab.org Lab webpage] <br>
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*I am a Postdoctoral Researcher in [[Odom|Duncan Odom's laboratory]] at the [http://science.cancerresearchuk.org/cri/ Cambridge Research Insitute]
 
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*My PhD and some postdoctoral work was done in the [[koop|Koop lab]] at the [http://web.uvic.ca/cbr/ Centre for Biomedical Research] at [http://www.uvic.ca University of Victoria].  
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= Education=
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<blockquote>
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PhD, Department of Biology, University of Victoria.<br>
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B.Sc., University of Victoria. Biochemistry and Hispanic studies.<br>
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</blockquote>
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= Short Bio =
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<blockquote>
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2012 - present : [http://www.wilsonlab.org Assistant Professor], Department of Molecular Genetics, University of Toronto, Toronto, Canada.<br>
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2012 - present : [http://www.sickkids.ca/AboutSickKids/Directory/People/W/Mike-Wilson-staff-profile.html Scientist], Genetics & Genome Biology Program, Hospital For Sick Children, Toronto, Canada.<br>
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2009 - 2012 : [http://www.clarehall.cam.ac.uk/index.php?id=62 Clare Hall Research Fellow]
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University of Cambridge.<br>
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2007 - 2012 : Postdoctoral Fellow in [[Odom|Duncan Odom's laboratory]] at the [http://science.cancerresearchuk.org/cri/ Cambridge Research Institute] in close 
 +
collaboration with Paul Flicek's [http://www.ebi.ac.uk/vg/ Vertebrate Genomics Team] at the European Bioinformatics Institute.<br>
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2006 - 2007 : Postdoctoral work with [http://web.uvic.ca/~bioweb/people/facpages/howard.php Perry Howard], University of Victoria.<br>
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2002 - 2003 : Visiting scientist in [http://www.mshri.on.ca/nagy/Andras Nagy's laboratory], Samuel Lunenfeld Institute, Mt. Sinai Hospital, Toronto.<br>
 +
1998 - 2005 : Doctoral student in  [[koop|Ben Koop's molecular evolution group]] at the [http://web.uvic.ca/cbr/ Centre for Biomedical Research] at [http://www.uvic.ca University of Victoria]. <br>
 +
</blockquote>
= Research Interests =
= Research Interests =
<blockquote>  
<blockquote>  
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*Understanding the role that regulatory DNA sequence plays in childhood diseases using comparative genomics, bioinformatics and developmental biology<br>
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=Current Research=
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*Epigenetics and evolution of regulatory networks in postnatal germ cells <br>
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===Evolution of transcription factor binding===
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*Functional characterization of human genome innovations <br>
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An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.
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=Ongoing research=
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===Uncovering the function of novel genes involved in reproduction and development===
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**Zonadhesin -- Zonadhesin is a novel gene that is under positive selection and is hypothesized to play a role in the species specific recognition of sperm and egg in mammals (In collaboration with Steve Tardif, Daniel Hardy and Andras Nagy)
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**Ars2 -- Ars2 was first discovered by others as a gene that conferred arsenite resistance to an arsenite sensitive cell line. We characterized this gene in humans and mice and are currently studying the phenotype of Ars2 mutants. This is an ongoing collaboration with Perry Howard.
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**Gnrhr -- Using gene-trap methods to understand Gnrhr function. This is a collaboration with Dr. Nancy Sherwood and Sheng Wu.
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===Comparative genomics and evolution===
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**Genomic regions associated with duplications, insertions, deletions and disease
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**7q11 William-Beuren syndrome
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**7q22 Acute myeloid leukemia
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===Evolution of new genes===
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**PVRIG and the Paired immunoglobulin like receptors
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**Novel genes generated by segmental duplication
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= Education=
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<blockquote>PhD, Department of Biology, University of Victoria.<br>
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B.Sc., University of Victoria. Biochemistry and Hispanic studies.
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<br>
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</blockquote>
</blockquote>
=Publications=
=Publications=
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<blockquote>
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<biblio>
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#Schmidt D*, Schwalie PC*, Wilson MD, Ballester B, Gonçalves A, Kutter C, Brown GD, Marshall A, Flicek P, Odom DT. Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages. Cell. 2012 Jan 20;148(1-2):335-48. Epub 2012 Jan 12.
-
 
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#Laudadio I, Manfroid I, Achouri Y, Schmidt D, Wilson MD, Cordi S, Thorrez L, Knoops L, Jacquemin P, Schuit F, Pierreux CE, Odom DT, Peers B, Lemaigre FPA Feedback Loop Between The Liver-Enriched Transcription Factor Network and Mir-122 Controls Hepatocyte Differentiation. Gastroenterology. 2011 Sep 12.
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#ref16 pmid=19913406
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#Kutter C, Brown GD, Gonçalves A, Wilson MD, Watt S, Brazma A, White RJ, Odom DT.Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.Nat Genet. 2011 Aug 28;43(10):948-55. doi: 10.1038/ng.906.
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#ref15 pmid=19275939
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#Tardif S*, Wilson MD*, Wagner R, Hunt P, Gertsenstein M, Nagy A, Lobe C, Koop BF, Hardy DM: Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. J Biol Chem 2010, 285:24863-2487010.1074/jbc.M110.123125.
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#ref14 pmid=19002256
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#Schmidt D*, Wilson MD*, Ballester B*, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, Odom DT: Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science 2010, 328:1036-104010.1126/science.1186176.
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#ref13 pmid=18787134
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#Wu S, Wilson MD, Busby ER, Isaac ER, Sherwood NM: Disruption of the Single Copy Gonadotropin-Releasing Hormone Receptor in Mice by Gene Trap: Severe Reduction of Reproductive Organs and Functions in Developing and Adult Mice. Endocrinology 2010, 151:1142-115210.1210/en.2009-0598.
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#ref12 pmid=18086880
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#Wilson MD, Odom DT: Evolution of transcriptional control in mammals. Curr Opin Genet Dev 2009, 19:579-58510.1016/j.gde.2009.10.003.
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#ref11 pmid=17957245
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#Schmidt D, Wilson MD, Spyrou C, Brown GD, Hadfield J, Odom DT: ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods 2009, 48:240-24810.1016/j.ymeth.2009.03.001.
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#ref10 pmid=16926269
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#Wilson MD*, Barbosa-Morais NL*, Schmidt D, Conboy CM, Vanes L, Tybulewicz VLJ, Fisher EMC, Tavaré S, Odom DT: Species-specific transcription in mice carrying human chromosome 21. Science 2008, 322:434-43810.1126/science.1160930.
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#ref9 pmid=16303057
+
#Wilson MD, Wang D, Wagner R, Breyssens H, Gertsenstein M, Lobe C, Lu X, Nagy A, Burke RD, Koop BF, Howard PL: ARS2 is a conserved eukaryotic gene essential for early mammalian development. Mol Cell Biol 2008, 28:1503-151410.1128/MCB.01565-07.
-
#ref8 pmid=12914656
+
#Schmidt D*, Stark R*, Wilson MD, Brown GD, Odom DT: Genome-scale validation of deep-sequencing libraries. PLoS ONE 2008, 3:e371310.1371/journal.pone.0003713.
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#ref7 pmid=12877756
+
#Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, Odom DT: Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. PLoS ONE 2007, 2:e106110.1371/journal.pone.0001061.
-
#ref6 pmid=12719377
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#Wilson MD, Cheung J, Martindale DW, Scherer SW, Koop BF: Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Physiol Genomics 2006, 27:201-21810.1152/physiolgenomics.00284.2005.
-
#ref5 pmid=12690205
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#Hunt P, Wilson M, Schalburg von K, Davidson W, Ben Koop: Expression and genomic organization of zonadhesin-like genes in three species of fish give insight into the evolutionary history of a mosaic protein. BMC Genomics 2005, 6:16510.1186/1471-2164-6-165.
-
#ref4 pmid=11929860
+
#Wen XY, Hegele RA, Wang J, Wang DY, Cheung J, Wilson M, Yahyapour M, Bai Y, Zhuang L, Skaug J, Young TK, Connelly PW, Koop BF, Tsui LC, Stewart AK.Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Hum Mol Genet. 2003 May 15;12(10):1131-43.
-
#ref3 pmid=11746756
+
#Scherer SW et al.: Human chromosome 7: DNA sequence and biology. Science 2003, 300:767-77210.1126/science.1083423.
-
#ref2 pmid=11239002
+
#Cheung J, Wilson MD, Zhang J, Khaja R, MacDonald JR, Heng HHQ, Koop BF, Scherer SW: Recent segmental and gene duplications in the mouse genome. Genome Biol 2003, 4:R4710.1186/gb-2003-4-8-r47.
-
#ref1 pmid=11003705
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#Montpetit A, Wilson MD, Chevrette M, Koop BF, Sinnett D. Analysis of the conservation of synteny between Fugu and human chromosome 12. BMC Genomics. 2003; 4(1):30.
-
#bookref1 Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000.
+
#Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA, Triggs-Raine BL: Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. J Biol Chem 2002, 277:23008-2301810.1074/jbc.M108991200.
 +
#Wilson M, Ruttan C, Koop B, Glickman B: ERCC1: A comparative genomic perspective. Environ Mol Mutagen 2001, 38:209-215.
 +
#Wilson M, Riemer C, Martindale D, Schnupf P, Boright A, Cheung T, Hardy D, Schwartz S, Scherer S, Tsui L, Miller W, Koop B: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res 2001, 29:1352-1365.
 +
#Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome 2000, 11:890-898.
 +
#Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000.
 +
'*' co-first authors
 +
</blockquote>
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</biblio>
 
|}
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Current revision


Michael D. Wilson, PhD
Scientist
Genetics & Genome Biology Program
SickKids, Research Institute
Genetics & Genome Biology Program
101 College St. East Tower | Suite 15-306
SickKids, Research Institute
Toronto, Ontario, Canada
M5G 1L7
phone:416.813.7654 | Ext. 28699
email: michael.wilson ^at^ sickkids ^dot^ ca
Official SickKids webpage
U of T faculty page
Lab webpage


Contents

Education

PhD, Department of Biology, University of Victoria.
B.Sc., University of Victoria. Biochemistry and Hispanic studies.

Short Bio

2012 - present : Assistant Professor, Department of Molecular Genetics, University of Toronto, Toronto, Canada.
2012 - present : Scientist, Genetics & Genome Biology Program, Hospital For Sick Children, Toronto, Canada.
2009 - 2012 : Clare Hall Research Fellow University of Cambridge.
2007 - 2012 : Postdoctoral Fellow in Duncan Odom's laboratory at the Cambridge Research Institute in close collaboration with Paul Flicek's Vertebrate Genomics Team at the European Bioinformatics Institute.
2006 - 2007 : Postdoctoral work with Perry Howard, University of Victoria.
2002 - 2003 : Visiting scientist in Nagy's laboratory, Samuel Lunenfeld Institute, Mt. Sinai Hospital, Toronto.
1998 - 2005 : Doctoral student in Ben Koop's molecular evolution group at the Centre for Biomedical Research at University of Victoria.

Research Interests

  • Understanding the role that regulatory DNA sequence plays in childhood diseases using comparative genomics, bioinformatics and developmental biology
  • Epigenetics and evolution of regulatory networks in postnatal germ cells
  • Functional characterization of human genome innovations

Publications

  1. Schmidt D*, Schwalie PC*, Wilson MD, Ballester B, Gonçalves A, Kutter C, Brown GD, Marshall A, Flicek P, Odom DT. Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages. Cell. 2012 Jan 20;148(1-2):335-48. Epub 2012 Jan 12.
  2. Laudadio I, Manfroid I, Achouri Y, Schmidt D, Wilson MD, Cordi S, Thorrez L, Knoops L, Jacquemin P, Schuit F, Pierreux CE, Odom DT, Peers B, Lemaigre FPA Feedback Loop Between The Liver-Enriched Transcription Factor Network and Mir-122 Controls Hepatocyte Differentiation. Gastroenterology. 2011 Sep 12.
  3. Kutter C, Brown GD, Gonçalves A, Wilson MD, Watt S, Brazma A, White RJ, Odom DT.Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.Nat Genet. 2011 Aug 28;43(10):948-55. doi: 10.1038/ng.906.
  4. Tardif S*, Wilson MD*, Wagner R, Hunt P, Gertsenstein M, Nagy A, Lobe C, Koop BF, Hardy DM: Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. J Biol Chem 2010, 285:24863-2487010.1074/jbc.M110.123125.
  5. Schmidt D*, Wilson MD*, Ballester B*, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, Odom DT: Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science 2010, 328:1036-104010.1126/science.1186176.
  6. Wu S, Wilson MD, Busby ER, Isaac ER, Sherwood NM: Disruption of the Single Copy Gonadotropin-Releasing Hormone Receptor in Mice by Gene Trap: Severe Reduction of Reproductive Organs and Functions in Developing and Adult Mice. Endocrinology 2010, 151:1142-115210.1210/en.2009-0598.
  7. Wilson MD, Odom DT: Evolution of transcriptional control in mammals. Curr Opin Genet Dev 2009, 19:579-58510.1016/j.gde.2009.10.003.
  8. Schmidt D, Wilson MD, Spyrou C, Brown GD, Hadfield J, Odom DT: ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods 2009, 48:240-24810.1016/j.ymeth.2009.03.001.
  9. Wilson MD*, Barbosa-Morais NL*, Schmidt D, Conboy CM, Vanes L, Tybulewicz VLJ, Fisher EMC, Tavaré S, Odom DT: Species-specific transcription in mice carrying human chromosome 21. Science 2008, 322:434-43810.1126/science.1160930.
  10. Wilson MD, Wang D, Wagner R, Breyssens H, Gertsenstein M, Lobe C, Lu X, Nagy A, Burke RD, Koop BF, Howard PL: ARS2 is a conserved eukaryotic gene essential for early mammalian development. Mol Cell Biol 2008, 28:1503-151410.1128/MCB.01565-07.
  11. Schmidt D*, Stark R*, Wilson MD, Brown GD, Odom DT: Genome-scale validation of deep-sequencing libraries. PLoS ONE 2008, 3:e371310.1371/journal.pone.0003713.
  12. Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, Odom DT: Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. PLoS ONE 2007, 2:e106110.1371/journal.pone.0001061.
  13. Wilson MD, Cheung J, Martindale DW, Scherer SW, Koop BF: Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Physiol Genomics 2006, 27:201-21810.1152/physiolgenomics.00284.2005.
  14. Hunt P, Wilson M, Schalburg von K, Davidson W, Ben Koop: Expression and genomic organization of zonadhesin-like genes in three species of fish give insight into the evolutionary history of a mosaic protein. BMC Genomics 2005, 6:16510.1186/1471-2164-6-165.
  15. Wen XY, Hegele RA, Wang J, Wang DY, Cheung J, Wilson M, Yahyapour M, Bai Y, Zhuang L, Skaug J, Young TK, Connelly PW, Koop BF, Tsui LC, Stewart AK.Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Hum Mol Genet. 2003 May 15;12(10):1131-43.
  16. Scherer SW et al.: Human chromosome 7: DNA sequence and biology. Science 2003, 300:767-77210.1126/science.1083423.
  17. Cheung J, Wilson MD, Zhang J, Khaja R, MacDonald JR, Heng HHQ, Koop BF, Scherer SW: Recent segmental and gene duplications in the mouse genome. Genome Biol 2003, 4:R4710.1186/gb-2003-4-8-r47.
  18. Montpetit A, Wilson MD, Chevrette M, Koop BF, Sinnett D. Analysis of the conservation of synteny between Fugu and human chromosome 12. BMC Genomics. 2003; 4(1):30.
  19. Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA, Triggs-Raine BL: Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. J Biol Chem 2002, 277:23008-2301810.1074/jbc.M108991200.
  20. Wilson M, Ruttan C, Koop B, Glickman B: ERCC1: A comparative genomic perspective. Environ Mol Mutagen 2001, 38:209-215.
  21. Wilson M, Riemer C, Martindale D, Schnupf P, Boright A, Cheung T, Hardy D, Schwartz S, Scherer S, Tsui L, Miller W, Koop B: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res 2001, 29:1352-1365.
  22. Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome 2000, 11:890-898.
  23. Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000.

'*' co-first authors

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