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*I am a postdoctoral researcher in [[Odom|Duncan Odom's laboratory]] at the [ Cambridge Research Insitute]
*I am a postdoctoral researcher in [[Odom|Duncan Odom's laboratory]] at the [ Cambridge Research Institute]
*My PhD and some postdoctoral work was done in the [[koop|Koop lab]] at the [ Centre for Biomedical Research] at [ University of Victoria].  
*My PhD and some postdoctoral work was done in the [[koop|Koop lab]] at the [ Centre for Biomedical Research] at [ University of Victoria].  

Revision as of 14:01, 7 December 2009

Odom laboratory

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Michael D. Wilson, PhD
Clare Hall Research Fellow
University of Cambridge
Cancer Research UK - Cambridge Research Institute
Li Ka Shing Centre
Robinson Way, Cambridge,
email: michael.wilson ^at^ cancer ^dot^ org ^uk^


Research Interests

Current Research

Evolution of transcription factor binding

An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.

Ongoing research

Uncovering the function of novel genes involved in reproduction and development

    • Zonadhesin -- Zonadhesin is a novel gene that is under positive selection and is hypothesized to play a role in the species specific recognition of sperm and egg in mammals (In collaboration with Steve Tardif, Daniel Hardy and Andras Nagy)
    • Ars2 -- Ars2 was first discovered by others as a gene that conferred arsenite resistance to an arsenite sensitive cell line. We characterized this gene in humans and mice and are currently studying the phenotype of Ars2 mutants. This is an ongoing collaboration with Perry Howard.
    • Gnrhr -- Using gene-trap methods to understand Gnrhr function. This is a collaboration with Dr. Nancy Sherwood and Sheng Wu.

Comparative genomics and evolution

    • Genomic regions associated with duplications, insertions, deletions and disease
    • 7q11 William-Beuren syndrome
    • 7q22 Acute myeloid leukemia

Evolution of new genes

    • PVRIG and the Paired immunoglobulin like receptors
    • Novel genes generated by segmental duplication


PhD, Department of Biology, University of Victoria.
B.Sc., University of Victoria. Biochemistry and Hispanic studies.


  1. Wilson MD and Odom DT. . pmid:19913406. PubMed HubMed [ref16]
  2. Schmidt D, Wilson MD, Spyrou C, Brown GD, Hadfield J, and Odom DT. . pmid:19275939. PubMed HubMed [ref15]
  3. Schmidt D, Stark R, Wilson MD, Brown GD, and Odom DT. . pmid:19002256. PubMed HubMed [ref14]
  4. Wilson MD, Barbosa-Morais NL, Schmidt D, Conboy CM, Vanes L, Tybulewicz VL, Fisher EM, Tavaré S, and Odom DT. . pmid:18787134. PubMed HubMed [ref13]
  5. Wilson MD, Wang D, Wagner R, Breyssens H, Gertsenstein M, Lobe C, Lu X, Nagy A, Burke RD, Koop BF, and Howard PL. . pmid:18086880. PubMed HubMed [ref12]
  6. Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, and Odom DT. . pmid:17957245. PubMed HubMed [ref11]
  7. Wilson MD, Cheung J, Martindale DW, Scherer SW, and Koop BF. . pmid:16926269. PubMed HubMed [ref10]
  8. Hunt PN, Wilson MD, von Schalburg KR, Davidson WS, and Koop BF. . pmid:16303057. PubMed HubMed [ref9]
  9. Cheung J, Wilson MD, Zhang J, Khaja R, MacDonald JR, Heng HH, Koop BF, and Scherer SW. . pmid:12914656. PubMed HubMed [ref8]
  10. Montpetit A, Wilson MD, Chevrette M, Koop BF, and Sinnett D. . pmid:12877756. PubMed HubMed [ref7]
  11. Wen XY, Hegele RA, Wang J, Wang DY, Cheung J, Wilson M, Yahyapour M, Bai Y, Zhuang L, Skaug J, Young TK, Connelly PW, Koop BF, Tsui LC, and Stewart AK. . pmid:12719377. PubMed HubMed [ref6]
  12. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, and Tsui LC. . pmid:12690205. PubMed HubMed [ref5]
  13. Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA, and Triggs-Raine BL. . pmid:11929860. PubMed HubMed [ref4]
  14. Wilson MD, Ruttan CC, Koop BF, and Glickman BW. . pmid:11746756. PubMed HubMed [ref3]
  15. Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, and Koop BF. . pmid:11239002. PubMed HubMed [ref2]
  16. Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, and Koop BF. . pmid:11003705. PubMed HubMed [ref1]
  17. Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000. [bookref1]
All Medline abstracts: PubMed HubMed
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