User:Mdwilson

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An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.
An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.
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=Ongoing research=
 
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===Uncovering the function of novel genes involved in reproduction and development===
 
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**Zonadhesin -- Zonadhesin is a novel gene that is under positive selection and is hypothesized to play a role in the species specific recognition of sperm and egg in mammals (In collaboration with Steve Tardif, Daniel Hardy and Andras Nagy)
 
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**Ars2 -- Ars2 was first discovered by others as a gene that conferred arsenite resistance to an arsenite sensitive cell line. We characterized this gene in humans and mice and are currently studying the phenotype of Ars2 mutants. This is an ongoing collaboration with Perry Howard.
 
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**Gnrhr -- Using gene-trap methods to understand Gnrhr function. This is a collaboration with Dr. Nancy Sherwood and Sheng Wu.
 
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===Comparative genomics and evolution===
 
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**Genomic regions associated with duplications, insertions, deletions and disease
 
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**7q11 William-Beuren syndrome
 
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**7q22 Acute myeloid leukemia
 
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===Evolution of new genes===
 
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**PVRIG and the Paired immunoglobulin like receptors
 
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**Novel genes generated by segmental duplication
 
= Education=
= Education=

Revision as of 17:23, 21 March 2010

Odom laboratory

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Michael D. Wilson, PhD
Clare Hall Research Fellow
University of Cambridge
Cancer Research UK - Cambridge Research Institute
Li Ka Shing Centre
Robinson Way, Cambridge,
CB2 0RE
phone:01223404502
email: michael.wilson ^at^ cancer ^dot^ org ^uk^


Contents

Research Interests

Current Research

Evolution of transcription factor binding

An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.


Education

PhD, Department of Biology, University of Victoria.
B.Sc., University of Victoria. Biochemistry and Hispanic studies.

Publications

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  1. Error fetching PMID 20068010: [ref17]
  2. Error fetching PMID 19913406: [ref16]
  3. Error fetching PMID 19275939: [ref15]
  4. Error fetching PMID 19002256: [ref14]
  5. Error fetching PMID 18787134: [ref13]
  6. Error fetching PMID 18086880: [ref12]
  7. Error fetching PMID 17957245: [ref11]
  8. Error fetching PMID 16926269: [ref10]
  9. Error fetching PMID 16303057: [ref9]
  10. Error fetching PMID 12914656: [ref8]
  11. Error fetching PMID 12877756: [ref7]
  12. Error fetching PMID 12719377: [ref6]
  13. Error fetching PMID 12690205: [ref5]
  14. Error fetching PMID 11929860: [ref4]
  15. Error fetching PMID 11746756: [ref3]
  16. Error fetching PMID 11239002: [ref2]
  17. Error fetching PMID 11003705: [ref1]
  18. Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000. [bookref1]
All Medline abstracts: PubMed HubMed
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