Michael D. Wilson, PhD
- My PhD and some postdoctoral work was done in the Koop lab at the Centre for Biomedical Research at University of Victoria.
Evolution of transcription factor binding
An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.
Uncovering the function of novel genes involved in reproduction and development
- Zonadhesin -- Zonadhesin is a novel gene that is under positive selection and is hypothesized to play a role in the species specific recognition of sperm and egg in mammals (In collaboration with Steve Tardif, Daniel Hardy and Andras Nagy)
- Ars2 -- Ars2 was first discovered by others as a gene that conferred arsenite resistance to an arsenite sensitive cell line. We characterized this gene in humans and mice and are currently studying the phenotype of Ars2 mutants. This is an ongoing collaboration with Perry Howard.
- Gnrhr -- Using gene-trap methods to understand Gnrhr function. This is a collaboration with Dr. Nancy Sherwood and Sheng Wu.
Comparative genomics and evolution
- Genomic regions associated with duplications, insertions, deletions and disease
- 7q11 William-Beuren syndrome
- 7q22 Acute myeloid leukemia
Evolution of new genes
- PVRIG and the Paired immunoglobulin like receptors
- Novel genes generated by segmental duplication
EducationPhD, Department of Biology, University of Victoria.
B.Sc., University of Victoria. Biochemistry and Hispanic studies.
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- Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000.