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Michael D. Wilson, PhD Clare Hall Research Fellow University of Cambridge Cancer Research UK - Cambridge Research Institute Li Ka Shing Centre Robinson Way, Cambridge, CB2 0RE phone:01223404502 email: michael.wilson ^at^ cancer ^dot^ org ^uk^

• I am a postdoctoral researcher in Duncan Odom's laboratory at the Cambridge Research Institute

• My PhD and some postdoctoral work was done in the Koop lab at the Centre for Biomedical Research at University of Victoria.

Research Interests

Current Research

Evolution of transcription factor binding

An experimental and global comparison of core transcriptional regulatory programs in human to other model organisms will provide insight into the transcription factor binding events that are essential for liver function in mammals. We are detecting evolutionarily conserved regulatory protein binding events and their underlying DNA sequence and are also identifying novel, species-specific binding events. By identifying transcriptional regulatory networks in healthy tissue, we can make comparisons to cancerous, damaged or developing tissues. Furthermore, the methodology, and reagents developed here, will be directly applicable to future studies using a variety of tissues and tumours.

Education

PhD, Department of Biology, University of Victoria.
B.Sc., University of Victoria. Biochemistry and Hispanic studies.

Publications

Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, and Odom DT. . pmid:20378774. PubMed HubMed [ref18] Wu S, Wilson MD, Busby ER, Isaac ER, and Sherwood NM. . pmid:20068010. PubMed HubMed [ref17] Wilson MD and Odom DT. . pmid:19913406. PubMed HubMed [ref16] Schmidt D, Wilson MD, Spyrou C, Brown GD, Hadfield J, and Odom DT. . pmid:19275939. PubMed HubMed [ref15] Schmidt D, Stark R, Wilson MD, Brown GD, and Odom DT. . pmid:19002256. PubMed HubMed [ref14] Wilson MD, Barbosa-Morais NL, Schmidt D, Conboy CM, Vanes L, Tybulewicz VL, Fisher EM, Tavaré S, and Odom DT. . pmid:18787134. PubMed HubMed [ref13] Wilson MD, Wang D, Wagner R, Breyssens H, Gertsenstein M, Lobe C, Lu X, Nagy A, Burke RD, Koop BF, and Howard PL. . pmid:18086880. PubMed HubMed [ref12] Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, and Odom DT. . pmid:17957245. PubMed HubMed [ref11] Wilson MD, Cheung J, Martindale DW, Scherer SW, and Koop BF. . pmid:16926269. PubMed HubMed [ref10] Hunt PN, Wilson MD, von Schalburg KR, Davidson WS, and Koop BF. . pmid:16303057. PubMed HubMed [ref9] Cheung J, Wilson MD, Zhang J, Khaja R, MacDonald JR, Heng HH, Koop BF, and Scherer SW. . pmid:12914656. PubMed HubMed [ref8] Montpetit A, Wilson MD, Chevrette M, Koop BF, and Sinnett D. . pmid:12877756. PubMed HubMed [ref7] Wen XY, Hegele RA, Wang J, Wang DY, Cheung J, Wilson M, Yahyapour M, Bai Y, Zhuang L, Skaug J, Young TK, Connelly PW, Koop BF, Tsui LC, and Stewart AK. . pmid:12719377. PubMed HubMed [ref6] Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, and Tsui LC. . pmid:12690205. PubMed HubMed [ref5] Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA, and Triggs-Raine BL. . pmid:11929860. PubMed HubMed [ref4] Wilson MD, Ruttan CC, Koop BF, and Glickman BW. . pmid:11746756. PubMed HubMed [ref3] Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, and Koop BF. . pmid:11239002. PubMed HubMed [ref2] Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, and Koop BF. . pmid:11003705. PubMed HubMed [ref1] Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000. [bookref1] All Medline abstracts: PubMed HubMed