User:MichaelMoore: Difference between revisions

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I am a second year graduate student in the BBS program at Harvard Med and one of the Silver lab's newest members.  A major focus in Pam's lab is the system-wide analysis of RNA dynamics in yeast and mammalian cells.  To that end, several past and present Silver lab members have pioneered the use of chromatin immunoprecipitation followed by DNA microarray analysis (ChIP on chip) to examine the coupling of gene expression to nuclear organization, mRNA export, and various RNA processing events.  I am working with Michael Yu to characterize genome-wide recuitment patterns of several core and auxiliary RNA splicing factors in yeast.  It is our hope to understand the specificity of the major components of the splicing machinery and to correlate that data to variables such as expression levels, functional class, and gene structure. We expect our analysis to identify factors that couple splicing to transcription and other steps in mRNP biogenesis.  Ultimately we would like to extend our findings to mammalian systems, where the biochemical mechanism of splicing and many of the relevant RNA and protein effectors are highly conserved.
I am a second year graduate student in the BBS program at Harvard Med and one of the Silver lab's newest members.  I am interested in the system-wide dynamics of RNAs.  I am currently analyzing genome-wide recruitment patterns of RNA processing factors in yeast.

Revision as of 21:54, 17 February 2006

I am a second year graduate student in the BBS program at Harvard Med and one of the Silver lab's newest members. I am interested in the system-wide dynamics of RNAs. I am currently analyzing genome-wide recruitment patterns of RNA processing factors in yeast.

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