User:Nkuldell:20.020 working page: Difference between revisions
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==Introduction to Biological Engineering Design== | |||
A class for first-year MIT undergraduates who are interested in the engineering of biology.<br> | |||
* | <br> | ||
*enabling technologies | [NK, can we renumber to 20.001A, allowing for a future in which 20.001B and 20.001C might cover engineering aproaches applied to biological '''science''' and engineering approaches applied to '''biomedical''' work, respectively?]<br> | ||
* | [DE, we can call it whatever the hell you want but I kinda liked the 20:20 number...it's the vision thing...the other niche versions sound great though...how many can we teach?] | ||
End of term project will be specification of a system, allowing a smooth transition to iGEM if desired.<br> | |||
==Key Concepts== | |||
*Understand the operation of genetic programs in prokaryotes and eukaryotes. | |||
*Describe key enabling technologies that support the engineering of biology, including synthesis, abstraction and standardization. | |||
*Develop awareness of issues of human practice that result from the development and application of biological technologies. | |||
==Organiziation== | |||
End of term project will be specification of the design of a system, allowing for a smooth transition to iGEM summer undergraduate research experience if desired.<br> | |||
Class tentative setup as 4-0-8 | Class tentative setup as 4-0-8 | ||
* 2x1hr lecture | * 2x1hr lecture | ||
* 2x1hr recitation (one to cover journal articles and other as Q/A time with TA) | * 2x1hr recitation (one to cover journal articles and other as Q/A time with TA) | ||
* eight hours of work outside of class | * eight hours of work outside of class | ||
Assessment | |||
==Assessment== | |||
* 2x1hr in class exams | * 2x1hr in class exams | ||
* final design project | * final design project | ||
* no final exam | * no final exam | ||
==Draft Syllabus== | |||
{| border=1px | {| border=1px | ||
|'''WEEK''' | |'''WEEK''' |
Latest revision as of 11:47, 7 September 2006
Introduction to Biological Engineering Design
A class for first-year MIT undergraduates who are interested in the engineering of biology.
[NK, can we renumber to 20.001A, allowing for a future in which 20.001B and 20.001C might cover engineering aproaches applied to biological science and engineering approaches applied to biomedical work, respectively?]
[DE, we can call it whatever the hell you want but I kinda liked the 20:20 number...it's the vision thing...the other niche versions sound great though...how many can we teach?]
Key Concepts
- Understand the operation of genetic programs in prokaryotes and eukaryotes.
- Describe key enabling technologies that support the engineering of biology, including synthesis, abstraction and standardization.
- Develop awareness of issues of human practice that result from the development and application of biological technologies.
Organiziation
End of term project will be specification of the design of a system, allowing for a smooth transition to iGEM summer undergraduate research experience if desired.
Class tentative setup as 4-0-8
- 2x1hr lecture
- 2x1hr recitation (one to cover journal articles and other as Q/A time with TA)
- eight hours of work outside of class
Assessment
- 2x1hr in class exams
- final design project
- no final exam
Draft Syllabus
WEEK | DAY | Lecture topic | Recitation article | For Next Time |
1 | 1 | Welcome | BioText/DesignText | |
1 | 2 | NASCAR tour of the cell [1] | Lives of a Cell [2] | DNA structure refresher |
2 | 1 | Bacterial gene expression | Sigma description/Jacob and Monod | Standards:digital vs analog Measurements: PoPS vs Northern |
2 | 2 | Noisy gene expression | Weiss/van Oudenaarden | Measurements: cell vs bulk |
3 | 1 | Genetic switch | Mark P-tashne | Standards: transfer curve |
3 | 2 | Genetic circuit design | Toggle/Repressilator | Standards: genetically encoded logic functions |
4 | 1 | Registry: parts, devices, systems | Composition | Measurements: device (bacterial photography system?) characterization |
4 | 2 | Composition: physical vs functional | Standard assembly | |
5 | 1 | Review session | Q/A with TA | |
5 | 2 | Exam I | break | |
6 | 1 | Evolution | Darwin-lite | Standards: comment on ID ruling |
6 | 2 | Synthesis technologies | ||
7 | 1 | Forward genetics Reverse engineering |
Design of genetic screens [3] | read: genetics text, plus genetics problem set |
7 | 2 | Sequencing projects | Systematic analysis of yeast genome [4][5] | Standards: Registry vs SGD Measurements: SGD Project Task A |
8 | 1 | Foundations for engineering: abstraction | ||
8 | 2 | Foundations for engineering: decoupling | Project Task B | |
9 | 1 | Reverse genetics Forward engineering |
T7.1 [6] | |
9 | 2 | Application: engineering therapeutics | JK's work [7] CV's work [8] | Preliminary project description due |
10 | 1 | Application: engineering for bioremediation/of bioresponsive agents | ||
10 | 2 | Review session | Q/A with TA | |
11 | 1 | Exam II | no recitation | |
11 | 2 | Socially responsible engineering | Help session for final project | |
12 | 1 | Final project presentations (poster session if class large?) | ||
12 | 2 | class evaluation |