User:Norville: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
 
(12 intermediate revisions by the same user not shown)
Line 15: Line 15:




==Objective: A [http://www.sciam.com/article.cfm?articleID=0006160D-B90B-1CDA-B4A8809EC588EEDF&pageNumber=8&catID=4 "Magic Machine*"] for Rapidly Creating Membrane Protein Crystals==
I am interested in using a combination of approaches including biomolecular materials, biochemistry, electron crystallography, molecular biology, and synthetic biology in order to create a general method for building protein crystals (in particular membrane protein crystals) in a deterministic fashion.


I think that most of the technology to create this "magic machine" or tool for creating membrane protein crystals already exists, however, it will take some time to put all the pieces together to create a working prototype.
==Undergraduate Students==
 
Victoria Chou<br>
Helping me in this adventure are my collaborators and undergraduate students.
Debra Lin <br>
 
Nomeda Girnius<br>
 
John Healy<br>
* The "Magic Machine" is a device imagined by Roderick MacKinnon in the linked interview.


==Advisors, Collaborators, and Influential Guides==
Angela Belcher and the Belcher Lab <br>
Tom Knight and the Knight Lab <br>
Deborah Kelly and Tom Walz <br>
Shuguang Zhang, Andreas Mershin, and the Zhang Lab <br>
George Church and the Church Lab <br>
Stuart Licht <br>
Gerry Sussman <br>
Malancha Gupta and Karen Gleason <br>
Hector Hernandez <br>
The Gast Lab<br>
Bruce Tidor<br>
The Instructors of the Cold Spring Harbor Protein Purification Course<br>
others. . .


==Undergraduate Students (Current)==
John Healy (formerly of the Axel Lab)<br>


Interested undergraduates may contact me at norville at mit dot edu <br>
==Publications==
 
==Undergraduate Students (Alumni)==
Victoria Chou<br>
Debra Lin <br>
Nomeda Girnius<br>


Julie E. Norville, Deborah F. Kelly, Thomas F. Knight, Angela M. Belcher, and Thomas Walz, “7 Å projection map of the S-layer protein sbpA obtained with trehalose embedded monolayer crystals.” Accepted by Journal of Structural Biology.


==Side Projects==
A. Amy Yu, Peter R. Stone, Julie E. Norville, Michael Vaughn, Eden J. Pacsial, Barry D. Bruce, Marc Baldo, Francisco M. Raymo, and Francesco Stellacci, A simple atomic force microscopy method for the visualization of polar and non-polar parts in thin organic films, Journal of Experimental Nanoscience, 1(1), 63-73, 2006.
[http://openwetware.mit.edu/index.php?title=Bioinformatics_of_S-layer_Proteins Bioinformatics of S-layer Proteins]


==Prior Work==
Rupa Das, Patrick J. Kiley, Michael Segal, Julie Norville, A. Amy Yu, Leyu Wang, Scott Trammell, L. Evan Reddick, Rajay Kumar, Francesco Stellacci, Nikolai Lebedev, Joel Schnur, Barry D. Bruce, Shuguang Zhang, and Marc Baldo. “Integration of Photosynthetic Protein Molecular Complexes in Solid-State Electronic Devices.” Nano Letters, 4 (6), 1079-1083, 2004. Among others, this article was featured in the November 11, 2004 New York Times article “Spinach Power Adds Muscle to Batteries” by Katie Zezima and the Nature news article “Could laptops run on spinach?” by Philip Ball, June 21, 2005.
(with others) Photoresist as a sacrificial layer by dissolution in acetone.
Micro Electro Mechanical Systems, 2001. MEMS 2001.


(with others) Integration of photosynthetic protein molecular complexes in solid-state electronic devices. Nano Lett, 2004
Ken Walsh, Julie E. Norville, and Yu-Chong Tai, “Photoresist as a Sacrificial Layer by Dissolution in Acetone,” IEEE MEMS, Interlaken, Switzerland, January 21-25, 2001.

Latest revision as of 16:50, 18 July 2007

Biography

Ph.D. Candidate in Electrical Engineering and Computer Science at MIT.
My advisors are Tom Knight and Angela Belcher.
M.S. in Electrical Engineering and Computer Science at MIT, 2004
B.S. in Electrical Engineering from the California Institute of Technology, 2002

Contact information

Julie Norville
MIT CSAIL
32 Vassar Street, Room 32-311
Cambridge, MA 02139
USA
626.235.3751
norville AT mit DOT edu


Undergraduate Students

Victoria Chou
Debra Lin
Nomeda Girnius
John Healy


Publications

Julie E. Norville, Deborah F. Kelly, Thomas F. Knight, Angela M. Belcher, and Thomas Walz, “7 Å projection map of the S-layer protein sbpA obtained with trehalose embedded monolayer crystals.” Accepted by Journal of Structural Biology.

A. Amy Yu, Peter R. Stone, Julie E. Norville, Michael Vaughn, Eden J. Pacsial, Barry D. Bruce, Marc Baldo, Francisco M. Raymo, and Francesco Stellacci, A simple atomic force microscopy method for the visualization of polar and non-polar parts in thin organic films, Journal of Experimental Nanoscience, 1(1), 63-73, 2006.

Rupa Das, Patrick J. Kiley, Michael Segal, Julie Norville, A. Amy Yu, Leyu Wang, Scott Trammell, L. Evan Reddick, Rajay Kumar, Francesco Stellacci, Nikolai Lebedev, Joel Schnur, Barry D. Bruce, Shuguang Zhang, and Marc Baldo. “Integration of Photosynthetic Protein Molecular Complexes in Solid-State Electronic Devices.” Nano Letters, 4 (6), 1079-1083, 2004. Among others, this article was featured in the November 11, 2004 New York Times article “Spinach Power Adds Muscle to Batteries” by Katie Zezima and the Nature news article “Could laptops run on spinach?” by Philip Ball, June 21, 2005.

Ken Walsh, Julie E. Norville, and Yu-Chong Tai, “Photoresist as a Sacrificial Layer by Dissolution in Acetone,” IEEE MEMS, Interlaken, Switzerland, January 21-25, 2001.