User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory

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==Project Description/Abstract==
 
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==Notes==
 
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* Our review paper on [[Media:GeneticEncodeMemory.pdf |genetically encoded memory ]] (in preparation)
 
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*  (to be removed)[[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/10 | summary note of site-specific recombinases]]
 
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*  [[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/11/03| List of site-specific recombinases]]
 
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*  [[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/11/07| Assay for site-specific recombinase profiling]]
 
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* Presentation: [[Media:DNAwriter.ppt| writing to DNA]] (present to Infinite Monkey Theorem Group, 11/01/98)
 
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==Links==
 
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*[[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/11/08 | labs]] that work on recombinases]]
 
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==Outline==
 
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# Application
 
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# Grand Challenges
 
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# Start-up experiments
 
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# Review Articles
 
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==Project List==
 
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* [[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/06| Synthetic Jumping DNA from Integrase/excisionase system]]
 
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*[[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/12 |Implementing N-bit memory with DNA recombination]]
 
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*[[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/15 |Engineering cell-cycle reporter]]
 
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* [[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/14 |Quantitative functional profiles (Database) of site-specific recombinase]]
 
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* [[User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/11 |Expanding Integrase/excisionase library]]
 
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==Conceptual questions==
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* In the abstract level, how could we live with imperfect efficiency? No matter writing mechanism we choose in the end, the fraction of cells whose genome is actually rewritten will likely to be significantly less than a hundred percent.
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* What are the common/ different challenges between writing memory to DNA versus gene therapy/ transgenic?
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* Why reaction of some DNA integration is irreversible but most other don't?
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