User:Pakpoom Subsoontorn/Notebook/general reading/2008/10/22: Difference between revisions

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*** Targeted ligands:
*** Targeted ligands:
** Designing Algorithms:
** Designing Algorithms:
**** Identify amino acid sequences that can form a complementary surface between the protein and the target ligand
** Testing Results:
** Testing Results:
*** Binding Affinities
*** binding affinities/selectivities
*** Rewiring Pathways
*** Rewiring Pathways
* Summary/Critique
* Summary/Critique

Revision as of 09:48, 23 October 2008

Project name <html><img src="/images/9/94/Report.png" border="0" /></html> Main project page
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Computational design of receptor and sensor proteins with novel functions(BioE300a presentation)

Outline

  • Challenges in designing protein
    • Complexity of protein-ligand interaction, too many possibility
    • Two approaches
      • Rational Design
      • Directed Evolution
  • What's new here?
    • Specific goals: changes the specificity of receptors/sensor protein
      • Precursors/ligand:
      • Targeted ligands:
    • Designing Algorithms:
        • Identify amino acid sequences that can form a complementary surface between the protein and the target ligand
    • Testing Results:
      • binding affinities/selectivities
      • Rewiring Pathways
  • Summary/Critique
  • More recent papers



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