Vijaya Parthiban's Home in OWW
I completed my Ph.D. and currently working as a 'staff scientist' in Colonge University Bioinformatics Center, Germany. I was selected for the Ph.D. program in International Max Planck Research School in Cologne in 2002.
My institution (CUBIC) is one of the highly funded bioinformatics facilities in the world and the quality of research is exceptional in its class. Besides, I have also been selected for the international Ph.D. program offered by IMPRS which involves competitive selection strategies. The scientific, social and career oriented training offered by this program helps the students to compete in international level.
As a member of the structural bioinformatics group at CUBIC, the main focus of my work is on computational prediction of protein structural stability. I have analysed and predicted the stability of proteins upon mutations. This study has a huge impact on the industrial applications for designing thermostable mutants, analysing the protein stability upon mutations that cause diseases, etc. The prediction model involves statistical mechanics functions and thorough identification of protein structural factors and has direct implications on protein structure solutions, protein-protein/ligand docking and virtual screening of potential drug targets. The study involves a lot of statistics, mathematics and statistical mechanics and empirical approaches to manipulate the experimental data. I am familiar with statistical tools and libraries to do cluster analysis, PCA, normilization and various linear regressions methods.
Areas of Interest
- Structural bioinformatics
- Drug discovery
- Protein-Ligand docking
- Molecular modelling
- Statistical data
- Vijaya Parthiban, M. Michael Gromiha and Dietmar Schomburg. CUPSAT: Predicting Protein Stability Changes upon Point Mutations (2006) (Nucleic Acids Research, in press).
- Vijaya Parthiban, M. Michael Gromiha, Christian Hoppe and Dietmar Schomburg. Structural Analysis and Prediction of Protein Mutant Stability using Distance and Torsion Potentials: Role of Secondary Structure and Solvent Accessibility. (Proteins: Structure, Function and Bioinformatics, in press).
- Devi Mariappan, Johannes Winkler, Vijaya Parthiban, Michael Xavier Doss, Jürgen Hescheler, Agapios Sachinidis. (2006) Dietary small molecules and large-scale gene expression studies: An experimental approach for understanding their beneficial effects on the development of malignant and non-malignant proliferative diseases. (Current Medicinal Chemistry, in press).
- ISMB / ECCB 2004, Glasgow: Poster Title: Prediction of Factors Determining Changes in Thermostability in Protein Mutants.
- GCB 2004, Bielefeld: Poster Title: Prediction of Factors Determining Changes in Thermostability in Protein Mutants (with improved results).
- ISMB 2005, Detroit: Two posters were presented. Poster Title 1: Computational Analysis of RNA Binding Proteins Based On Composition, Sequence And Structural Information. Poster Title 2: http://www.iscbsc.org - A New Professional Web-based ISCB Student Council Framework for Computational Biology Support
- ECCB 2005, Madrid: Optimisation of Atomic Interaction Models for An Effective Description Of Protein Structure Parameters.
- ESF-JSPS workshop on Functional Genomics: From the Bench to Bioinformatics. Talk: ‘Structural Analysis and Prediction of Protein Mutant Stability using Distance and Torsion Potentials: Role of Secondary Structure and Solvent Accessibility’