User:Ryan T. Willett

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[[Image:rtw_portrait.jpg|thumb|right|Ryan T. Willett]]
[[Image:rtw_portrait.jpg|thumb|right|Ryan T. Willett]]
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I am a postdoc in the Laboratory of Lloyd Greene at Columbia University, having just finished my PhD in the lab. A wide spectrum of topics and problems interest me but my work lately has been centered around combinatorial transcription factor expression and its role on cell fate selection in neural differentiation. [[OpenWetWare]] caught my attention in a writeup on DIY, howebrew biology in New Scientist magazine.
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I am a starting up my postdoc in the laboratory of Alexandra Joyner at MSKCC. Our lab is interested in developmental and pathological processes regulated by Sonic Hedgehog (SHH) signaling and in how the morphology, cytoarchitecture, cell fate specification, and circuitry formation of the cerebellum is achieved. My project, in its beginning stages, will focus on characterization of the function of the Engrailed family of homeodomain transcription factors, identification of gene targets that they act upon during transcriptional regulation, and identification of protein cofactors that they bind with to carry out this function.
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[[OpenWetWare]] caught my attention in a writeup on DIY, howebrew biology in New Scientist magazine.
==Contact Info==
==Contact Info==
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*Laboratory of Lloyd Greene
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*Laboratory of Alexandra Joyner
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*Columbia University - Department of Pharmacology
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*Sloan-Kettering Institute - Developmental Biology Program
*New York, NY, USA  
*New York, NY, USA  
*[[Special:Emailuser/Ryan T. Willett|Contact Information]]
*[[Special:Emailuser/Ryan T. Willett|Contact Information]]
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* 2002 BS, Brandeis University - Biology
* 2002 BS, Brandeis University - Biology
* 2002 BA, Brandeis University - Biochemistry
* 2002 BA, Brandeis University - Biochemistry
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* 2000 Harvard University Medical School. Summer Fellowship in the Laboratory of T Keith Blackwell at the Center for Blood Research (now the Immune Disease Institute)
 
==Awards==
==Awards==
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==Publications==
==Publications==
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#Paper1 pmid=6947258
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#Paper2 pmid=13718526
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#Paper3 pmid=21430145
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#Book1 isbn=0879697164
#Book1 isbn=0879697164
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Revision as of 11:31, 25 March 2011

Ryan T. Willett
Ryan T. Willett

I am a starting up my postdoc in the laboratory of Alexandra Joyner at MSKCC. Our lab is interested in developmental and pathological processes regulated by Sonic Hedgehog (SHH) signaling and in how the morphology, cytoarchitecture, cell fate specification, and circuitry formation of the cerebellum is achieved. My project, in its beginning stages, will focus on characterization of the function of the Engrailed family of homeodomain transcription factors, identification of gene targets that they act upon during transcriptional regulation, and identification of protein cofactors that they bind with to carry out this function.

OpenWetWare caught my attention in a writeup on DIY, howebrew biology in New Scientist magazine.

Contents

Contact Info

  • Laboratory of Alexandra Joyner
  • Sloan-Kettering Institute - Developmental Biology Program
  • New York, NY, USA
  • Contact Information

Education

  • 2010 PhD, Columbia University
  • 2002 BS, Brandeis University - Biology
  • 2002 BA, Brandeis University - Biochemistry

Awards

  • Brian Hoffman Award for Excellence in Graduate Studies
  • Graduated with High Honors in Biology for the undergraduate thesis "Posttranscriptional Analysis of Circadian Rhythms" in the laboratory of Michael Rosbash

Expertise

  • molecular biology
  • RNA/DNA/protein biochemistry
  • cell culture and generation of stable cell lines
  • dissection and primary cell culture
  • animal surgery
  • in utero electroporation of DNA into rat embryos
  • pseudotype recombinant retrovirus production and purification
  • histology

Research interests

  1. Neural Development
  2. Stem cell biology
  3. Cancer biology
  4. Genetic Engineering / Gene Therapy
  5. Bioengineering
  6. Biochemistry
  7. Bioinformatics

Publications

  1. Willett RT and Greene LA. . pmid:21430145. PubMed HubMed [Paper3]
  2. Mark Ptashne. A genetic switch. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004. isbn:0879697164. [Book1]

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Biswas SC, Zhang Y, Iyirhiaro G, Willett RT, Rodriguez-Gonzalez Y, Cregan SP, Slack RS, Park DS, Greene LA. (2010) SERTAD1 Plays an Essential Role in Developmental and Pathological Neuron Death. J Neurosci 30(11):3973-3982

Malagelada C, Lopez-Toledano MA, Willett RT, Jin ZH, Shelanski ML, Greene LA. Role of RTP801 in Neural Stem Cell Maintenance and Differentiation. (in submission)

Willett RT and Greene LA. Gata2 is Required for Migration and Differentiation of retinorecipient neurons in the superior colliculus. (in submission)

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