User:Sarah A Boswell

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Contact Info

Sarah A Boswell (an artistic interpretation)

Sarah A Boswell

Harvard Medical School

200 Longwood Ave.

Boston, MA 02115

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I work in the Springer_Lab at Harvard Medical School. I learned about OpenWetWare from a grad student in lab.

Education

• 2003, PhD, Rensselaer Polytechnic Institute

Dissertation: The folding of the dimeric protein factor for inversion stimulation

• 1999, BS, Rensselaer Polytechnic Institute

Research Project in the Springer Lab - FLEXIQuant

We have developed a novel mass spectrometry method that promises to be sufficiently cheap, straightforward and reliable to provide high-throughput measurements of the absolute level of proteins in cells and tissues, and at the same time both identify peptides that are post-translationally modified and quantite the level of modification. Our primary goal in this proposal is to comprehensively characterize 1,000 proteins and thereby to demonstrate that it is possible to scale the technology to make such measurements at a quasi-genomic level across multiple cell types (6 cell lines).

Other Research interests

1. Protein folding and misfolding
2. The cellular response to reactive oxygen stress (ROS)
3. The unfolded protein response (UPR)

Publications

<biblio>

1. Paper1 pmid=6947258
2. Paper2 pmid=13718526
11. PMID=12070319

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