User:Sean C. Sleight

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Contact Info

Sean C. Sleight (an artistic interpretation)
Sean C. Sleight (an artistic interpretation)

I'm a postdoc in Herbert Sauro's lab at University of Washington. I have just started a synthetic biology project and will be an advisor for the UW iGEM 2008 team. Hopefully I will be able to contribute something here soon.


  • 2007, PhD, Michigan State University, Microbiology and Molecular Genetics
  • 1999, BS, University of Arizona, Molecular and Cellular Biology

Research interests

  1. Synthetic biology (standards, modular gene networks, stochasticity, feed-forward loops)
  2. Evolution (using it as a friend of synthetic biology instead of an enemy)
  3. Mutation rates under stress


  • Sleight S.C., N.S. Wigginton, and R.E. Lenski.

Increased susceptibility to repeated freeze-thaw cycles in Escherichia coli following long-term evolution in a benign environment. 2006. BMC Evolutionary Biology 6: 104 [8 pp].

  • Sleight S.C. and R.E. Lenski.

Evolutionary adaptation to freeze-thaw-growth cycles in Escherichia coli. 2007. Physiological and Biochemical Zoology 80(4): 370-385.

  • Sleight S.C., C. Orlic, D. Schneider, and R.E. Lenski.

Genetic basis of evolutionary adaptation by Escherichia coli to stressful cycles of freezing, thawing and growth (submitted to Genetics).

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