User:Sebastian Muller Dunelm
Contact Information
- Sebastian Müller
- Institut Curie
- 26, Rue d'Ulm, 75248
- Paris, France
- Email me
Currently, I work in the G. Almouzni Lab at the Institut Curie as a postdoctoral researcher in epigenetics and chromatin dynamics.
Education
- 2010, Ph.D., University of Cambridge (England, U.K.)
- 2006, M.Sci, Durham University (England, U.K.)
- 2002, CPE, Lincoln College (England, U.K.)
- 2001, German Abitur, Evangelisches Schulzentrum Leipzig (Germany)
- 1999, GCSE, Lomond School (Scotland, U.K.)
Research Interests
- Exploring Chromatin Dynamics with Small Molecules
- Cancer research: molecular and cellular mechanisms of the aetiology of cancer
- DNA structure and function
- G-quadruplex DNA and RNA
- Synthesis of nucleic acid interacting small molecules
- Epigenetic roles of DNA and RNA structures
- Centromeres and satellite DNA
Skills
- Languages: German (fluent), English (fluent), French (fluent)
- Cell & Molecular Biology: Cell culture, Immunohistochemistry, fluorescence microscopy, fluorescent and luminescent cell assays (apoptosis, senescence, viability, cytotoxicity etc.), transfections, cloning, q-PCR, colony PCR, agarose and PA gel electrophoresis, DNA extraction, radioactive labelling, immunoprecipitation & pull down
- Chemical Synthesis: Synthesis of small synthetic molecules, NMR, UV-vis, HRMS
- Biophysics: FRET-melting, circular dichroism, nucleic acid NMR, fluorescent titration
- I.T.: LaTeX, HTML, OriginLab, ChemDraw, Microsoft Office, Photoshop
- Teaching: A-level teaching, teaching of undergrad students in supervisions and tutorials up to Masters level, supervision of 1st year Ph.D. students
Awards
- 2011-current: Marie Curie Actions Postdoctoral Fellowship on the Nucleosome 4D network
- 2006-2010: Cancer research UK, Scholarship, Cambridge, U.K.
- 2005: Full Colours in Rowing, Durham University, College of St. Hild & St. Bede, U.K.
- 2001: Buchpreis der Deutschen Physikalischen Gesellschaft, Germany
Personal Interests
- Rowing
- Classical Music
- Gym and running
- Piano
- Ancient and modern history and archeology
- Astronomy
Publications
[1] S. Müller, G. Almouzni, Biochim. Biophys. Acta., 2014, 1839, 241-50 “A network of players in H3 histone variant deposition and maintenance at centromeres”
[2] S. Müller, D. Sanders, R. Rodriguez, M. Di Antonio, S. Matsis and S. Balasubramanian, Org Biomol. Chem., 2012, 10, 6537-6546 “Small molecules that show selective growth inhibition for cancer cells, low cytotoxicity and induce telomere shortening”
[3] M. Bejugam, M. Gunaratman, S. Müller, S. Sewitz, D. A. Sanders, S. Neidle and S. Balasubramanian, ACS Med. Chem. Lett., 2010, 1, 306-310, “Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines”
[4] S. Müller, S. Kumari, R. Rodriguez and S. Balasubramanian, Nature Chem., 2010, 2, 1095-1098, “Small molecule-mediated G-Quadruplex isolation from human cells”
[5] S. Müller, G. D. Pantos, R. Rodriguez and S. Balasubramanian, Chem.Commun., 2009, 80-82, “Controlled-folding of a small molecule modulates DNA G-quadruplex recognition”
[6] R. Rodriguez, S. Müller, J. A. Yeoman, C. Trentesaux, J.-F. Riou and S. Balasubramanian, J. Am. Chem. Soc., 2008, 130, 15758-15759, “A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres”
[7] J. Jaiswal, G. Marlow, G. Summerill, I. Mahjneh, S. Müller, M. Hill, K. Miyake, H. Haase, L. Anderson, I. Richard, S. Kiuru-Enari, P. McNeil, S. Simon and R. Bashir, Traffic, 2006, 8, 77-88, “Patients with a non-dysferlin Myoshi Myopathy have a novel membrane repair defect”
[8] J. Jaiswal, K. Miyake, G. Summerill, S. Müller, I. Mahjneh, F. Baas, M. de Visser, P. McNeil and R. Bashir, Neuromuscular Disorders, 2005, 15, 692, “Defective membrane repair in non-dysferlin Miyoshi Myopathy”
Groups
S. Balasubramanian Research Group
