User:Shimon Weiss

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Shimon Weiss

affiliation

Distinguished Professor, Department of Chemistry and Biochemistry, UCLA
 (Dean M. Willard Chair in Chemistry, 2009-)
http://www.chem.ucla.edu/dept/Faculty/sweiss/
Distinguished Professor, Department of Physiology, UCLA
http://www.physiology.ucla.edu/faculty/sweiss.html
Professor, Department of Physics, Bar-Ilan University
http://physics.biu.ac.il/en/node/3531

Education

Sc.D., Israel Institute of Technology, 1989
B.S., Technion, Israel Institute of Technology, 1984
Post-doctoral Fellowship: 1989 - 1990, Rothschild Fellowship

Research interests

• 2005 Rank Prize (Royal College of Physicians, London)
• 2001 Biophysical Society Award (Michael and Kate Barany)
• 1999 Fellow (Optical Society of America)
• 1993 Outstanding Performance Award, Lawrence Berkeley Laboratory (The Director)

Professional Societies:

• AAAS
• ACS
• APS
• Biophysical Society
• Fellow, Optical Society of America (1999)

Back to Weiss Lab!

Selected Publications

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Michalet X, Siegmund OHW, Vallerga JV, Jelinsky P, Pinaud FF, Millaud JE, Weiss S, Fluorescence lifetime microscopy with a time-and space-resolved single-photon counting detector, Optics East, 2006, 63720E-63720E-8.

Nir E, Michalet X, Hamadani KM, Laurence TA, Neuhauser D, Kovchegov Y, Weiss S, Shot-noise limited single-molecule FRET histograms: comparison between theory and experiments, The Journal of Physical Chemistry B, 2006, 110(44), 22103-22124.

Kapanidis AN, Margeat E, Ho SO, Kortkhonjia E, Weiss S, Ebright RH, Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism, Science, 2006, 314(5802), 1144-1147.

Iyer G, Pinaud F, Tsay JM, Li JJ, Bentolila LA, Michalet X, Weiss S, Peptide coated quantum dots for biological applications, IEEE transactions on nanobioscience, 2006, 5(4), 231-238.

Michalet X, Siegmund OHW, Vallerga JV, Jelinsky P, Millaud JE, Weiss S, A space-and time-resolved single photon counting detector for fluorescence microscopy and spectroscopy, Biomedical Optics 2006, 60920M-60920M-8.

Iyer G, Li JJ, Pinaud F, Tsay JM, Bentolila LA, Michalet X, Weiss S, Near-infrared peptide-coated quantum dots for small animal imaging, Biomedical Optics 2006, 60960B-60960B-6

Ohnuki T, Michalet X, Tripathi A, Weiss S, Arisaka K, Development of an ultrafast single photon counting imager for single molecule imaging, Biomedical Optics 2006, 60920P-60920P-9.

Margeat E, Kapanidis AN, Tinnefeld P, Wang Y, Mukhopadhyay J, Ebright RH, Weiss S, Direct Observation of Abortive Initiation and Promoter Escape within Single Immobilized Transcription Complexes, Biophysical Journal, 2006, 90(4), 1419-1431.

Pinaud F, Michalet X, Tsay JM, Doose S, Li JJ, Iyer G, Weiss S, Advances in fluorescence imaging with quantum dot bio-probes, Biomaterials, 2006, 27 (9), 1679-87.

Michalet X, Siegmund OHW, Vallerga JV, JelinskyP, Millaud JE and Weiss S, Detectors for ingle -molecule fluorescence imaging and spectroscopy, Journal of Modern Optics, 2006, 54 (2-3), 239.

Bentolila LA, Weiss S, Single-step multicolor fluorescence in situ hybridization using semiconductor quantum dot-DNA conjugates, Cell Biochemistry and Biophysics, 2006, 45, 59-70.

Michalet X, Siegmund OHW, Vallerga JV, Jelinsky P, Millaud JE, Weiss S, Photon-Counting H33D Detector for Biological Fluorescence Imaging, Nuclear Instruments and Methods in Phyiscs Research, 2006, 567 (1), 133–136.

Tsay JM, Doose S and Weiss S, Rotational and Translational Diffusion of CdSe/CdS/ZnS Nanorods Studied by Fluorescence Correlation Spectroscopy, J. Am. Chem. Soc., 2006, 128 (5), 1639.

Michalet X, Weiss S, Jger M, Single-molecule Fluorescence Studies of Protein Folding and Conformational Dynamics, Chemical Reviews, , 2006, 106 (5), 1785-813.

Jager M, Nir E, Weiss S, Site-specific labeling of proteins for single molecule FRET by combining chemical and enzymatic modification, Protein Science, 2006, 15, 640-646.

Michalet X, Weiss S, Using Photon Statistics to Boost Microscopy Resolution, PNAS, 2006, 103 (13), 4797-4798.

Margeat E, Kapanidis AN, Tinnefeld P, Wang Y, Mukhopadhyay J, Ebright RH and Weiss S, Direct observation of abortive initiation and promoter escape within single immoblized transcription complexes, Biophys J., 2005, 90, 1419-1431.

James MT, Sren D, Fabien P, and Shimon W, Enhancing the Photoluminescence of Peptide-coated Nanocrystals, Proceedings of SPIE on Progress on Biomedical Optics and imaging:, Nanobiophotonics and Biomedical Applications II, 2005, 6 (20), 139-147.

Tsay J, Doose S, Pinaud F, Weiss S, Enhancing the photoluminescence of peptide-coated CdSe nanocrystals with shell composition and UV irradiation, J. Phys. Chem B., 2005, 109, 1669-1674.

Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Iyer G, Weiss S, Peptide-coated semiconductor nanocrystals for biomedical applications, Proceedings of SPIE, 2005, 5704, 57-68.

Jager M, Michalet X, Weiss S, Protein-protein interactions as a tool for site specific labeling of proteins, Protein Science, 2005, 14, 2059-2068.

Michalet X, Pinaud F, Bentolila LA, Tsay J, Doose S, Li J, Sundaresan G, Wu AM, Gambhir SS, Weiss S, Quantum Dots for Live Cells and in vivo Imaging, Diagnostics and Beyond, Science , 2005, 307 (5709), 538-544.

Kapanidis AN, Margeat E, Laurence TA, Doose S, Ho, SO, Kortkhonjia ME, Mekler V, Ebright RH and Weiss S, Retention of transcription initation factor ??70 in transcription elongation: single molecule analysis, Molecular Cell, 2005, 20 (3), 347-56. Lee NK, Kapanidis AN, Michalet X, Mukhophadyay J, Ebright RH, Weiss S, Towards structure from single biomolecules: accurate FRET through alternating-laser excitation, Biophys J, 2005, 88 (4), 2939-2953.

Li JJ, Tsay J, Michalet X, Weiss S, Wave-function engineering: from quantum wells to near-infrared type-II colloidal quantum dots synthesized by layer-by-layer colloidal epitaxy, Chemical Physics (Special Issue on Molecular Nanoscience-In Honor of Daniel S. Chemla on his 65th Birthday), 2005, 318, 82-90.

Laurence TA, Kong X, Jager M, Weiss S, Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins, Proc Natl Acad Sci U S A., 2005, 102 (48), 17348-53 .

Kapanidis AN, Laurence TA, Lee NK, Margeat E, Kong X, Weiss S, Alternating-laser excitation of single molecules., Accounts of chemical research. , 2005, 38 (7), 523-33.

Lee, NK Kapanidis, AN Wang, Y Michalet, X Mukhopadhyay, J Ebright, RH Weiss, S, Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation., Biophysical journal. , 2005, 88 (4), 2939-53.

Doose S, Tsay JM, Pinaud F, Weiss S, Comparison of photophysical and colloidal properties of biocompatible semiconductor nanocrystals using fluorescence correlation spectroscopy., Analytical chemistry. , 2005, 77 (7), 2235-42.

Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S, Quantum dots for live cells, in vivo imaging, and diagnostics., Science. , 2005, 307 (5709), 538-44.

Kapanidis AN,Lee NK, Laurence TA, Doose S, Margeat E, Weiss S, Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules., Proceedings of the National Academy of Sciences of the United States of America. , 2004, 101 (24), 8936-41.

Kapanidis AN, Lee NK, Laurence TA, Doose S, Margeat E, Weiss S, Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules., Proceedings of the National Academy of Sciences of the United States of America. , 2004, 101 (24), 8936-41.

Pinaud F, King D, Moore HP, Weiss S, Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides., Journal of the American Chemical Society. , 2004, 126 (19), 6115-23.

Tsay JM, Pflughoefft M, Bentolila LA, Weiss S, Hybrid approach to the synthesis of highly luminescent CdTe/ZnS and CdHgTe/ZnS nanocrystals., Journal of the American Chemical Society. , 2004, 126 (7), 1926-7.

Michalet X, Kapanidis AN, Laurence T, Pinaud F, Doose S, Pflughoefft M, Weiss S, The power and prospects of fluorescence microscopies and spectroscopies., Annual review of biophysics and biomolecular structure. , 2003, 32, 161-82. Deniz AA, Laurence TA, Dahan M, Chemla DS, Schultz PG and Weiss S, "Ratiometric single-molecule studies of freely diffusing biomolecules.", Annual Reviews in Physical Chemistry, 2001, 52, 233-253.

Gerion D, Pinaud F, Williams SG, Parak WJ, Zanchet D, Weiss S, and Alivisatos AP, "Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots.", to be published in Journal of Physical Chemistry B (web version published as a ASAP paper, 5 June 2001), 2001.

Dahan M, Laurence T, Herten DP, Schumacher A, Chemla DS, Alivisatos AP, Sauer M and Weiss S, "Time-gated biological imaging using colloidal quantum dots", Optics Letters, 2001, 26, 825-827.

Weiss S, "Measuring Conformational Dynamics of Biomolecules by Single Molecule Fluorescence Spectroscopy.", Nature Structural Biology, 2000, 7, 724-729. Weiss S, "Shattering the diffraction limit of light: A revolution in fluorescence microscopy?", Proc. Natl. Acad. Sci. USA, 2000, 97, 8747-8749.

Deniz AA, Laurence T, Beligere GS, Dahan M, Martin AB, Chemla DS, Dawson PE, Schultz PG and Weiss S, "Single molecule protein folding: diffusion Forster energy transfer studies of the denaturation of Chymotrypsin inhibitor 2", Proc. Natl. Acad. Sci. USA, 2000, 97, 5179-5184.

Lacoste TD, Michalet X, Pinaud F, Chemla DS, Alivisatos AP and Weiss S, "Ultrahigh-resolution multicolor colocalization of single fluorescent probes", PNAS Proc. Natl. Acad. Sci. USA, 97, 2000, 97, 9461-9466.

Banin U, Bruchez M, Alivisatos AP, Ha T, Weiss S and Chemla DS, " Evidence for a thermal contribution to emission intermittency in single CdSe/CdS core/shell nanocrystals", J. Chem. Phys., 1999, 110, 1195-1201.

Weiss S, "Fluorescence Spectroscopy of Single Biomolecules.", Science, 1999, 283, 1676-1683.

Ha T, Laurence T, Ting AY, Schultz PG, Chemla DS and Weiss S, "Polarization spectroscopy of single fluorescent molecules", J. Chem. Phys. B, 1999, 103, 9839-9850.

Dahan M, Deniz A, Ha T, Grunwel J, Schultz PG, Chemla DS and Weiss S, "Ratiometric identification and separation of single molecules diffusing in solution", Chem. Phys., 1999, 247, 85-106.

Deniz AA, Dahan M, Ha T, Grunwell J, Faulhaber A, Chemla DS, Weiss S and Schultz PG, "Ratiometric single pair FRET on freely diffusing molecules - observation of Forster distance dependence and of sub-populations", Proc. Natl. Acad. Sci. USA, 1999, 96, 3670-3675.

Ha T, Ting AY, Liang J, Caldwell WB, Deniz A, Chemla DS, Schultz PG and Weiss S, "Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism", Proc. Natl. Acad. Sci. USA, 1999, 96, 893-898. Ha T, Ting AY, Liang J, Deniz AA, Chemla DS, Schultz PG and Weiss S, Temporal Fluctuations of Fluorescence Resonance Energy Transfer between Two Dyes Conjugated to a Single Protein, Chem. Phys., 1999, 247, 107-118.

Ha T, Glass J, Chemla DS and Weiss S, "Hindered rotational diffusion and rotational jumps of single molecules", Phys. Rev. Lett., 1998, 80, 2093. Enderle T, Ha T, Chemla DS and Weiss S, "Near-field fluorescence microscopy of cells", Ultramicroscopy, 1998, 71, 303.

Bruchez Jr M,Moronne M, Gin P, Weiss S, and Alivisatos AP, "Semiconductor nanocrystals as fluorescent biological labels", Science, 1998, 281, 2013-2016. Ha T, Enderle T, Selvin PR, Chemla DS and Weiss S, "Room temperature observation of quantum jumps", Chem. Phys. Lett., 1997, 271, 1.

Ha T and Chemla DS, Enderle T and Weiss S, "Single molecule spectroscopy with automated positioning", Appl. Phys. Lett. , 1997, 70, 782.

Ha T, Chemla DS, Enderle T and Weiss S, "Strategy for room temperature spectroscopy of single molecules", Bioimaging, 1997, 5, 99.
Enderle T, Ha T, Chemla DS, Magowan C and Weiss S, "Surface specific mapping and co-localization of malarial and host proteins in red-blood-cell membrane by dual-color near-field scanning optical microscopy", Proc. Natl. Acad. Sci. USA, 1997, 94, 520.

Ha T, Enderle T, Chemla DS and Weiss S, "Dual-molecule spectroscopy: molecular rulers for the study of biological macromolecules", IEEE Journal of Special Topics in Quantum Electronics, 1996, 2, 1115.

Ha T, Enderle T, Ogletree DF, Chemla DS, Selvin P and Weiss S, "Probing the interaction between two single molecules: Fluorescence resonance energy transfer between a single donor and a single acceptor", Proc. Natl. Acad. Sci. USA, 1996, 93, 624.

Ha T, Enderle T, Chemla DS, Selvin PR and Weiss S, "Single molecule dynamics studied by polarization modulation", Phys. Rev. Lett., 1996, 77, 3979.