User:Slokwong/Module 4: Biomaterial Engineering

Research Proposal

• Project Overview

A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.

• Background
• Problem and Goals
• Project details and methods
• Predicted Outcomes

• Resources

http://web.mit.edu/newsoffice/2006/hemostasis.html

Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So. 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine 2: 207-215.

They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.

Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So; G. Schneider. 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS 103: 5054-5059.

Describes how the self-assembling peptide nanofiber scaffold was created and how it works.

Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee. 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation 111: 442-450.

They demonstrated that self-assembling peptides can be injected and that the resulting nanofiber microenvironments can be detected.

Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang. 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release 115: 18-25.

Describes the structure of self-assmebling peptide nanofibers.

http://www.innovitaresearch.org/news/06102501.html

Describes self-assembling peptide nanofiber scaffolds and what they are used for.

http://jama.ama-assn.org/cgi/content/full/297/1/31