User:Slokwong/Module 4: Biomaterial Engineering: Difference between revisions
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===Research Proposal=== | ===Research Proposal=== | ||
<font color=blue>'''Project Overview'''</font> | <font color=blue>'''Project Overview'''</font><br> | ||
*A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it. | *A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it. | ||
<font color=blue>'''Background'''</font> | <font color=blue>'''Background'''</font><br> | ||
< | |||
<font color=blue>'''Resources'''</font> | <font color=blue>'''Problem and Goals'''</font><br> | ||
1. http://web.mit.edu/newsoffice/2006/hemostasis.html | |||
<font color=blue>'''Project details and methods'''</font><br> | |||
<font color=blue>'''Predicted Outcomes'''</font><br> | |||
<font color=blue>'''Resources'''</font><br> | |||
1. http://web.mit.edu/newsoffice/2006/hemostasis.html <br> | |||
'''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215. | '''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215. |
Revision as of 12:35, 3 May 2007
Research Proposal
Project Overview
- A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.
Background
Problem and Goals
Project details and methods
Predicted Outcomes
Resources
1. http://web.mit.edu/newsoffice/2006/hemostasis.html
Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So. 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine 2: 207-215.
- They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.
2.Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So G. Schneider. 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS 103: 5054-5059.
- Describes how the self-assembling peptide nanofiber scaffold was created and how it works.
3.Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee. 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation 111: 442-450.
- They demonstrated that self-assembling peptides can be injected and that the resulting
nanofiber microenvironments can be detected.
4.Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang. 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release 115: 18-25.
- Describes the structure of self-assmebling peptide nanofibers.
5.http://www.innovitaresearch.org/news/06102501.html
- Describes self-assembling peptide nanofiber scaffolds and what they are used for.