User:Slokwong/Module 4: Biomaterial Engineering: Difference between revisions
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<font color=blue>'''Resources'''</font><br> | <font color=blue>'''Resources'''</font><br> | ||
1 | '''[1]''' http://web.mit.edu/newsoffice/2006/hemostasis.html <br> | ||
'''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215. | '''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215. | ||
| Line 36: | Line 36: | ||
*''They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.'' | *''They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.'' | ||
2 | '''[2]''' '''Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So G. Schneider.''' 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS '''103''': 5054-5059. | ||
*''Describes how the self-assembling peptide nanofiber scaffold was created and how it works.'' | *''Describes how the self-assembling peptide nanofiber scaffold was created and how it works.'' | ||
3 | '''[3]''' '''Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee.''' 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation '''111''': 442-450. | ||
*''They demonstrated that self-assembling peptides can be injected and that the resulting | *''They demonstrated that self-assembling peptides can be injected and that the resulting | ||
nanofiber microenvironments can be detected.'' | nanofiber microenvironments can be detected.'' | ||
4 | '''[4]''' '''Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang.''' 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release '''115''': 18-25. | ||
*''Describes the structure of self-assmebling peptide nanofibers.'' | *''Describes the structure of self-assmebling peptide nanofibers.'' | ||
5 | '''[5]''' http://www.innovitaresearch.org/news/06102501.html | ||
*''Describes self-assembling peptide nanofiber scaffolds and what they are used for.'' | *''Describes self-assembling peptide nanofiber scaffolds and what they are used for.'' | ||
Revision as of 12:46, 3 May 2007
Research Proposal
Project Overview
- A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.
Intro: reference article from MIT news
Background
- self-assembling peptides
- tumors (containment)
Problem and Goals
- Find effective way of containing/treating tumors. Find gel that specifically binds to tumor which can improve drug delivery techniques.
Project details and methods
- Finding the difference between tumor and normal cells (discovering the peptide in which the gel can bind to)
- Creating the peptide binding gel
- insertion
- binding specific site
- take from inorganic concept...
- Application (how to assist drug delivery)
Predicted Outcomes
- Pitfalls
- can't find a peptide to bind
- binds to more things than just the tumor
Resources
[1] http://web.mit.edu/newsoffice/2006/hemostasis.html
Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So. 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine 2: 207-215.
- They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.
[2] Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So G. Schneider. 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS 103: 5054-5059.
- Describes how the self-assembling peptide nanofiber scaffold was created and how it works.
[3] Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee. 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation 111: 442-450.
- They demonstrated that self-assembling peptides can be injected and that the resulting
nanofiber microenvironments can be detected.
[4] Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang. 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release 115: 18-25.
- Describes the structure of self-assmebling peptide nanofibers.
[5] http://www.innovitaresearch.org/news/06102501.html
- Describes self-assembling peptide nanofiber scaffolds and what they are used for.
