User:Soren Hough
I am a new member of OpenWetWare!
Contact Info
- Søren Hough
- (860) 798-5268 [Cell Phone]
- Email me through OpenWetWare
I began my research career with Henry Furneaux, PhD, at the age of 15. While learning the principles of wet lab work in the Furneaux Lab, I performed an in silico experiment testing for viral microRNA regulation of the BRCA1 tumor suppressor gene. I presented my research formally at the end of summer 2009 to the faculty of the University of Connecticut Schools of Medicine and Dental Medicine.
In the summer of 2010 I worked in a lab at the Douglas Mental Health Institute through McGill University doing research on differential gene expression in the brain. My investigations were done under the supervision of Gilles Maussion, PhD, and Gustavo Turecki, MD, PhD, as a part of the McGill Group for Suicide Studies.
The research team at the Turecki Lab was interested in monitoring the role epigenetics play in causing suicidal behavior. My project involved analyzing whether key genes involved in neuronal signaling were the target of microRNAs, methylation, and transcription factors.
In fall 2010, I worked as a student researcher in the developmental epigenetics laboratory of Jesse Mager, PhD, a one of twenty-three undergraduate participants in the CNS First-Year Research Experience.
The Mager Lab group’s objective was to look at how epigenetic factors affected embryogenesis. Using methyl-sensitive PCR, I investigated potential methylation sites in the promoter regions of two interrelated genes known to be expressed in oocytes, but not in the surrounding granulosa cells. I presented my research formally at the end of the semester.
Most recently, I worked in the molecular biophysics. laboratory of Jennifer Ross, PhD. There, I completed my honors thesis on intracellular transport. My project was to design a DNA origami structure to serve as a programmable artificial cargo to test the effect of kinesin-1 binding location on transport efficiency.
Education
- Microbiology, 2014, BS, Departmental Honors Scholar with Distinction, University of Massachusetts Amherst
- Film Studies, 2014, Certificate, University of Massachusetts Amherst
Research interests
- Kinesin/Cytoskeleton/Super Resolution Microscopy
- microRNAs and Epigenetics of Disease
Publications
1. Hough, S. H. “Using DNA Origami to Evaluate Motor Protein Binding Patterns.” Commonwealth Honors College, University of Massachusetts Amherst. 2014. 2. Hough, S. H. “Lloyd Garrison Seymour.” African American National Biographies, Harvard University Press and Oxford University Press. 2009.
