User:Thomas Dziubla

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== Thomas Dziubla ==
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==Thomas Dziubla==
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'''Assistant Professor'''<br>Department of Chemical and Materials Engineering <br>University of Kentucky<br>
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[[Image:dziubla-placehold.jpg|thumb|left|]]
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==Education==
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Thomas Dean Dziubla <br>
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'''Postdoctoral Fellow''', Institute for Environmental Medicine, University of Pennsylvania, Philadelphia PA<br>
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177 F Paul Anderson Tower, Lexington KY 40506-0046<br>
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'''PhD. Chemical Engineering''', Drexel University, Philadelphia, PA<br>
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Work: (859) 257-4063•Cell: (859) 940-6113<br>
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'''Honors B.S. Chemical Engineering'''', Purdue University, West Lafayette, IN<br><BR><br>
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Email: dziubla@engr.uky.edu<br>
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<BR>
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Academic Experience and Education:<br>
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July, 2006-Present University of Kentucky, Lexington, KY
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Assistant Professor, Department of Chemical and Materials Engineering<br>
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November, 2004-June 2006 University of Pennsylvania School of Medicine, Philadelphia, PA
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Research Associate, Institute for Environmental Medicine<br>
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November, 2002-November, 2004
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University of Pennsylvania School of Medicine, Philadelphia, PA
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NIH NRSA Postdoctoral Fellowship Award<br>
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November, 2002
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==Awards and Honors==
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Drexel University, Philadelphia, PA
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NIH NRSA Postdoctoral Fellow, Institute of Environmental Medicine<br>
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PhD. Chemical Engineering<br>
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3rd Place Research Award: Molecular Design In Drug Discovery & Development Symposium Series(2004)<br>
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Purdue University, West Lafayette, IN
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Biomaterials Annual Conference Travel Award:Honorable Mention(2003)<br>
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Honors B.S. Chemical Engineering
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Drexel University Graduate Student Research Award(2001)<br>
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Mollye and Mitchell Glick Scholarship Award(2001)<br>
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American Institute of Chemists Award, Drexel University(2000)<br>
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Sigma Xi Research Day-Graduate Student Research Award(2000)<br>
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Drexel University Dean’s Fellowship Award(1998,1999)<br>
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Awards:
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==Publications==
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2004 3rd Prize, Poster Competition: Molecular Design In Drug Discovery & Development Symposium Series
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M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles” Langmuir (Accepted)
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2003 Annual Biomaterials Meeting Travel Award: Honorable Mention
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2001 Drexel University Graduate Student Research Award
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2001 Mollye and Mitchell Glick Scholarship Award
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2000 American Institute of Chemists Award, Drexel University
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2000 Sigma Xi Research Day-Graduate Student Research Award
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1998, 1999 Drexel University Dean’s Fellowship Award
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<BR>
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Publications: (* denotes corresponding author)<br>
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C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET (In Revision)<br>
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J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu * “Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug” ACS Nano (accepted)
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T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.” Biomaterials 2:215-27 (2008)<br>
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J. Medley, Heisterberg J, and T Dziubla* “Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.” J Biomater Sci:Poly Ed (E Pub 2010)
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E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Amphiphilicity of PEG-PLA diblock copolymer controls the formulation and morphology of nanocarriers protecting loaded therapeutic enzyme from proteolysis” Biomacromolecules 8:3914-21 (2007) <br>
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P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.” Advanced Functional Materials 20:147-154 (2010)
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S. Muro*, T.D. Dziubla, W. Qui, J. Leferovich, X. Cui, E. Berk and V.R. Muzykantov  “Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1.” JPET 317(3):1161-9 (2006) <br>
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Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.” Food Chemistry 118:582-588 (2010)
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T.D. Dziubla*, A. Karim and V. Muzykantov, “Polymer nanocarriers (PNC) protect loaded catalase cargo from proteolysis.” Journal of Controlled Release 102(2), 427-439, (2005) <br>
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J. Medley, E. Beane, E. Kaplan and T Dziubla* “Block copolymers for the rational design of self-forming postsurgical adhesion barriers.” Acta Biomaterialia 6:72-82 (2010)
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T.D. Dziubla and A.M. Lowman*, “Vascularization of PEG-grafted macroporous hydrogel sponges: a 3-dimensional in vitro angiogenesis model utilizing human microvascular endothelial cells.” Journal of Biomedical Materials Research. 68A (4): 603-614, (2004) <br>
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E Simone*, T Dziubla, D Discher, and V Muzykantov. “Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.” Biomacromolecules 10:1324-30 (2009)
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T.D. Dziubla, M.C. Torjman, J.I. Joseph, M. Murphy-Tatum and A.M. Lowman*, "Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices." Biomaterials 22, 2893-2899, (2001)<p>
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E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “Loading PEG-catalase into filamentous and spherical polymer nanocarriers” Pharmaceutical Research 26:250-60 (2009)
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Conference Proceedings<br>
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E. Simone, T.D. Dziubla, and V. R Muzykantov., “Polymeric Carriers: Role of Geometry in Drug Delivery.” Expert Opinion on Drug Delivery 5:1283-1300 (2008)
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D. Besser, G. Swan, T. Dziubla and R. Eitel, “Building Continuous Loop Learning Communities: An Engineering Outreach Case Study” ASEE Southeast Spring Conference Proceedings (2008)<BR>
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A.M. Lowman, T.D. Dziubla and N.A. Peppas, “Novel networks and gels containing increased amounts of grafted and crosslinked poly(ethylene glycol).” ACS Polymer Prepr., 38(1), (1997) <BR>
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M. Howard, M Jay, T. Dziubla, X. Lu*, “PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.” J Biomed Nanotech 4:133-148 (2008)  
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Book Chapters and Review Articles
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C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET 325:400-408 (2008)
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E. Simone, T. Dziubla, V Shuvaev and V.R. Muzykantov, “Synthesis and Characterization of Polymer Nanocarriers for Therapeutic Enzyme Delivery.” In:, 2nd Edition for Methods in Molecular Biology: Free Radicals and Antioxidant Protocols (In Press)
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Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. “Advanced drug delivery systems that target the vascular endothelium.” Mol Interv. 2:98-112 (2006)
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T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.” Biomaterials 2:215-27 (2008)
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T.D. Dziubla and V. Muzykantov, “Nanocarriers for drug delivery to the pulmonary vasculature.” In: Nanoparticulates as Drug Carriers, V Torchilin, Ed. Imperial College Press, London. (2006)
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T.D. Dziubla and V. Muzykantov, “Synthetic carriers for the delivery of protein therapeutics.” In: Biotechnology and Genetic Engineering Reviews Vol. 22., S.E. Harding Ed., Lavoisier Publishing, Paris, France 267-298 (2006)
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E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Amphiphilicity of PEG-PLA diblock copolymer controls the formulation and morphology of nanocarriers protecting loaded therapeutic enzyme from proteolysis” Biomacromolecules 8:3914-21 (2007)
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S. Muro*, T.D. Dziubla, W. Qui, J. Leferovich, X. Cui, E. Berk and V.R. Muzykantov  “Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1.” JPET 317(3):1161-9 (2006)
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Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. “Advanced drug delivery systems that target the vascular endothelium.” Mol Interv. 2:98-112 (2006)
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T. Dziubla, S. Muro, V. R. Muzykantov and M. Koval, “Nanoscale antioxidant therapeutics.” In: Oxidative Stress, Disease and Cancer, Keshav K. Singh, Ed. Imperial College Press, London. (2006)
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T.D. Dziubla*, A. Karim and V. Muzykantov, “Polymer nanocarriers (PNC) protect loaded catalase cargo from proteolysis.” Journal of Controlled Release 102(2), 427-439, (2005)  
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A.M. Lowman, T.D. Dziubla, P. Bures and N.A. Peppas, “Structural and dynamic response of neutral and intelligent networks in biomedical environments.” in N.A. Peppas and M.V. Sefton, eds., “Advances in Chemical Engineering Vol 29: Molecular and Cellular Foundations of Biomaterials.” Academic Press, New York, (2004)  
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T.D. Dziubla and A.M. Lowman*, “Vascularization of PEG-grafted macroporous hydrogel sponges: a 3-dimensional in vitro angiogenesis model utilizing human microvascular endothelial cells.” Journal of Biomedical Materials Research. 68A (4): 603-614, (2004)  
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V. Shuvaev, T. Dziubla, R. Wiewrodt and V. Muzykantov, “Streptavidin-biotin cross-linking of therapeutic enzymes with carrier antibodies: nanoconjugates for protection against endothelial oxidative stress.” In: Methods in Molecular Biology V 283: Bioconjugation Protocols: Strategies and Methods, C.Niemeyer, Ed., Humana Press, (2004)
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T.D. Dziubla, M.C. Torjman, J.I. Joseph, M. Murphy-Tatum and A.M. Lowman*, "Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices." Biomaterials 22, 2893-2899, (2001)
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T.D. Dziubla, M.C. Torjman, J.I. Joseph and A.M. Lowman, “Implantable drug delivery devices: design of a biomimetic interfacial drug delivery system.” In: Biomimetic Materials and Design: Interactive Biointerfacial Strategies, Tissue Engineering, and Targeted Drug Delivery, A K Dillow and A M Lowman, Eds., Marcel Dekker, (2003)
 
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T.D. Dziubla and A.M. Lowman, “Smart gels.” In: Encyclopedia of Smart Materials, M. Schwartz  Ed. Wiley and Sons, (2001)
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[[dziubla Lab|Home]]

Current revision

Resources

Protocols
Equipment

  • DLS
  • Glovebox
  • Fluorimeter
  • Freeze Dryer
  • Uv-Vis
  • GPC/HPLC

Materials
Internal

Contact

Thomas Dziubla
Assistant Professor
Mat and Chem Engineering
University of Kentucky
177 F Paul Anderson Tower
Lexington, KY 40506-0046
dziubla-at-engr.uky.edu

Thomas Dziubla

Assistant Professor
Department of Chemical and Materials Engineering
University of Kentucky

Education

Postdoctoral Fellow, Institute for Environmental Medicine, University of Pennsylvania, Philadelphia PA
PhD. Chemical Engineering, Drexel University, Philadelphia, PA
Honors B.S. Chemical Engineering', Purdue University, West Lafayette, IN


Awards and Honors

NIH NRSA Postdoctoral Fellow, Institute of Environmental Medicine
3rd Place Research Award: Molecular Design In Drug Discovery & Development Symposium Series(2004)
Biomaterials Annual Conference Travel Award:Honorable Mention(2003)
Drexel University Graduate Student Research Award(2001)
Mollye and Mitchell Glick Scholarship Award(2001)
American Institute of Chemists Award, Drexel University(2000)
Sigma Xi Research Day-Graduate Student Research Award(2000)
Drexel University Dean’s Fellowship Award(1998,1999)

Publications

M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles” Langmuir (Accepted)

J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu * “Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug” ACS Nano (accepted)

J. Medley, Heisterberg J, and T Dziubla* “Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.” J Biomater Sci:Poly Ed (E Pub 2010)

P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.” Advanced Functional Materials 20:147-154 (2010)

Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.” Food Chemistry 118:582-588 (2010)

J. Medley, E. Beane, E. Kaplan and T Dziubla* “Block copolymers for the rational design of self-forming postsurgical adhesion barriers.” Acta Biomaterialia 6:72-82 (2010)

E Simone*, T Dziubla, D Discher, and V Muzykantov. “Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.” Biomacromolecules 10:1324-30 (2009)

E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “Loading PEG-catalase into filamentous and spherical polymer nanocarriers” Pharmaceutical Research 26:250-60 (2009)

E. Simone, T.D. Dziubla, and V. R Muzykantov., “Polymeric Carriers: Role of Geometry in Drug Delivery.” Expert Opinion on Drug Delivery 5:1283-1300 (2008)

M. Howard, M Jay, T. Dziubla, X. Lu*, “PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.” J Biomed Nanotech 4:133-148 (2008)

C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET 325:400-408 (2008)

T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.” Biomaterials 2:215-27 (2008)

E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Amphiphilicity of PEG-PLA diblock copolymer controls the formulation and morphology of nanocarriers protecting loaded therapeutic enzyme from proteolysis” Biomacromolecules 8:3914-21 (2007)

S. Muro*, T.D. Dziubla, W. Qui, J. Leferovich, X. Cui, E. Berk and V.R. Muzykantov “Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1.” JPET 317(3):1161-9 (2006)

Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. “Advanced drug delivery systems that target the vascular endothelium.” Mol Interv. 2:98-112 (2006)

T.D. Dziubla*, A. Karim and V. Muzykantov, “Polymer nanocarriers (PNC) protect loaded catalase cargo from proteolysis.” Journal of Controlled Release 102(2), 427-439, (2005)

T.D. Dziubla and A.M. Lowman*, “Vascularization of PEG-grafted macroporous hydrogel sponges: a 3-dimensional in vitro angiogenesis model utilizing human microvascular endothelial cells.” Journal of Biomedical Materials Research. 68A (4): 603-614, (2004)

T.D. Dziubla, M.C. Torjman, J.I. Joseph, M. Murphy-Tatum and A.M. Lowman*, "Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices." Biomaterials 22, 2893-2899, (2001)


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