User:Thomas Dziubla

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==Thomas Dziubla==
==Thomas Dziubla==
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Academic Experience and Education:<br>
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'''Assistant Professor'''<br>Department of Chemical and Materials Engineering <br>University of Kentucky<br>
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2006-Present University of Kentucky, Lexington, KY
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Assistant Professor, Department of Chemical and Materials Engineering<br>
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==Education==
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2004-2006 University of Pennsylvania School of Medicine, Philadelphia, PA
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'''Postdoctoral Fellow''', Institute for Environmental Medicine, University of Pennsylvania, Philadelphia PA<br>
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Research Associate, Institute for Environmental Medicine<br>
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'''PhD. Chemical Engineering''',  Drexel University, Philadelphia, PA<br>
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2002-2004
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'''Honors B.S. Chemical Engineering'''', Purdue University, West Lafayette, IN<br><BR><br>
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University of Pennsylvania School of Medicine, Philadelphia, PA
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NIH NRSA Postdoctoral Fellowship Award<br>
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==Awards and Honors==
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NIH NRSA Postdoctoral Fellow, Institute of Environmental Medicine<br>
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3rd Place Research Award: Molecular Design In Drug Discovery & Development Symposium Series(2004)<br>
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Biomaterials Annual Conference Travel Award:Honorable Mention(2003)<br>
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Drexel University Graduate Student Research Award(2001)<br>
 +
Mollye and Mitchell Glick Scholarship Award(2001)<br>
 +
American Institute of Chemists Award, Drexel University(2000)<br>
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Sigma Xi Research Day-Graduate Student Research Award(2000)<br>
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Drexel University Dean’s Fellowship Award(1998,1999)<br>
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==Publications==
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M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles” Langmuir (Accepted)
 +
 
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J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu * “Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug” ACS Nano (accepted)
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J. Medley, Heisterberg J, and T Dziubla* “Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.” J Biomater Sci:Poly Ed (E Pub 2010)
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P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.” Advanced Functional Materials 20:147-154 (2010)
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Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.” Food Chemistry 118:582-588 (2010)
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J. Medley, E. Beane, E. Kaplan and T Dziubla* “Block copolymers for the rational design of self-forming postsurgical adhesion barriers.” Acta Biomaterialia 6:72-82 (2010)
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E Simone*, T Dziubla, D Discher, and V Muzykantov. “Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.” Biomacromolecules 10:1324-30 (2009)
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E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “Loading PEG-catalase into filamentous and spherical polymer nanocarriers” Pharmaceutical Research 26:250-60 (2009)
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E. Simone, T.D. Dziubla, and V. R Muzykantov., “Polymeric Carriers: Role of Geometry in Drug Delivery.” Expert Opinion on Drug Delivery 5:1283-1300 (2008)
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M. Howard, M Jay, T. Dziubla, X. Lu*, “PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.” J Biomed Nanotech 4:133-148 (2008)
 +
 
 +
C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET 325:400-408 (2008)
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T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.” Biomaterials 2:215-27 (2008)
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 +
E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Amphiphilicity of PEG-PLA diblock copolymer controls the formulation and morphology of nanocarriers protecting loaded therapeutic enzyme from proteolysis” Biomacromolecules 8:3914-21 (2007)
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S. Muro*, T.D. Dziubla, W. Qui, J. Leferovich, X. Cui, E. Berk and V.R. Muzykantov  “Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1.” JPET 317(3):1161-9 (2006)
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 +
Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. “Advanced drug delivery systems that target the vascular endothelium.” Mol Interv. 2:98-112 (2006)
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T.D. Dziubla*, A. Karim and V. Muzykantov, “Polymer nanocarriers (PNC) protect loaded catalase cargo from proteolysis.” Journal of Controlled Release 102(2), 427-439, (2005)
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T.D. Dziubla and A.M. Lowman*, “Vascularization of PEG-grafted macroporous hydrogel sponges: a 3-dimensional in vitro angiogenesis model utilizing human microvascular endothelial cells.” Journal of Biomedical Materials Research. 68A (4): 603-614, (2004)
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2002
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T.D. Dziubla, M.C. Torjman, J.I. Joseph, M. Murphy-Tatum and A.M. Lowman*, "Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices." Biomaterials 22, 2893-2899, (2001)
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Drexel University, Philadelphia, PA
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PhD. Chemical Engineering<br>
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1998 Purdue University, West Lafayette, IN
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Honors B.S. Chemical Engineering
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[[dziubla Lab|Home]]

Current revision

Resources

Protocols
Equipment

  • DLS
  • Glovebox
  • Fluorimeter
  • Freeze Dryer
  • Uv-Vis
  • GPC/HPLC

Materials
Internal

Contact

Thomas Dziubla
Assistant Professor
Mat and Chem Engineering
University of Kentucky
177 F Paul Anderson Tower
Lexington, KY 40506-0046
dziubla-at-engr.uky.edu

Thomas Dziubla

Assistant Professor
Department of Chemical and Materials Engineering
University of Kentucky

Education

Postdoctoral Fellow, Institute for Environmental Medicine, University of Pennsylvania, Philadelphia PA
PhD. Chemical Engineering, Drexel University, Philadelphia, PA
Honors B.S. Chemical Engineering', Purdue University, West Lafayette, IN


Awards and Honors

NIH NRSA Postdoctoral Fellow, Institute of Environmental Medicine
3rd Place Research Award: Molecular Design In Drug Discovery & Development Symposium Series(2004)
Biomaterials Annual Conference Travel Award:Honorable Mention(2003)
Drexel University Graduate Student Research Award(2001)
Mollye and Mitchell Glick Scholarship Award(2001)
American Institute of Chemists Award, Drexel University(2000)
Sigma Xi Research Day-Graduate Student Research Award(2000)
Drexel University Dean’s Fellowship Award(1998,1999)

Publications

M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles” Langmuir (Accepted)

J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu * “Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug” ACS Nano (accepted)

J. Medley, Heisterberg J, and T Dziubla* “Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.” J Biomater Sci:Poly Ed (E Pub 2010)

P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.” Advanced Functional Materials 20:147-154 (2010)

Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.” Food Chemistry 118:582-588 (2010)

J. Medley, E. Beane, E. Kaplan and T Dziubla* “Block copolymers for the rational design of self-forming postsurgical adhesion barriers.” Acta Biomaterialia 6:72-82 (2010)

E Simone*, T Dziubla, D Discher, and V Muzykantov. “Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.” Biomacromolecules 10:1324-30 (2009)

E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “Loading PEG-catalase into filamentous and spherical polymer nanocarriers” Pharmaceutical Research 26:250-60 (2009)

E. Simone, T.D. Dziubla, and V. R Muzykantov., “Polymeric Carriers: Role of Geometry in Drug Delivery.” Expert Opinion on Drug Delivery 5:1283-1300 (2008)

M. Howard, M Jay, T. Dziubla, X. Lu*, “PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.” J Biomed Nanotech 4:133-148 (2008)

C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET 325:400-408 (2008)

T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.” Biomaterials 2:215-27 (2008)

E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Amphiphilicity of PEG-PLA diblock copolymer controls the formulation and morphology of nanocarriers protecting loaded therapeutic enzyme from proteolysis” Biomacromolecules 8:3914-21 (2007)

S. Muro*, T.D. Dziubla, W. Qui, J. Leferovich, X. Cui, E. Berk and V.R. Muzykantov “Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1.” JPET 317(3):1161-9 (2006)

Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. “Advanced drug delivery systems that target the vascular endothelium.” Mol Interv. 2:98-112 (2006)

T.D. Dziubla*, A. Karim and V. Muzykantov, “Polymer nanocarriers (PNC) protect loaded catalase cargo from proteolysis.” Journal of Controlled Release 102(2), 427-439, (2005)

T.D. Dziubla and A.M. Lowman*, “Vascularization of PEG-grafted macroporous hydrogel sponges: a 3-dimensional in vitro angiogenesis model utilizing human microvascular endothelial cells.” Journal of Biomedical Materials Research. 68A (4): 603-614, (2004)

T.D. Dziubla, M.C. Torjman, J.I. Joseph, M. Murphy-Tatum and A.M. Lowman*, "Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices." Biomaterials 22, 2893-2899, (2001)


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