User:Thomas Maiwald

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Contact Info

Thomas Maiwald (an artistic interpretation)

• Thomas Maiwald
• www.thomasmaiwald.de
• Email me through OpenWetWare

I cooperate with the lab of Prof. Peter Sorger in the Systems Biology department of the Harvard Medical School.

Education

• 2008, PhD, Freiburg Center of Data Analysis and Modeling, University of Freiburg, Germany
• 2003, Physics Diplom, University of Freiburg, Germany

Research interests

I am the developer of PottersWheel, a Matlab toolbox for parameter estimation in differential equation based mathematical models (www.potterswheel.de).

Publications

1. N Borisov, E Aksamitiene, A Kiyatkin, S Legewie, J Berkhout, T Maiwald, N Kaimachnikov, J Timmer, J Hoek, B Kholodenko, Systems-level interactions between insulin - EGF networks amplify mitogenic signaling, Molecular Systems Biology 2009, in press

2. Maiwald T and Timmer J. Dynamical modeling and multi-experiment fitting with PottersWheel. Bioinformatics. 2008 Sep 15;24(18):2037-43. DOI:10.1093/bioinformatics/btn350 |
3. Kreutz C, Bartolome Rodriguez MM, Maiwald T, Seidl M, Blum HE, Mohr L, and Timmer J. An error model for protein quantification. Bioinformatics. 2007 Oct 15;23(20):2747-53. DOI:10.1093/bioinformatics/btm397 |
4. Hengl S, Kreutz C, Timmer J, and Maiwald T. Data-based identifiability analysis of non-linear dynamical models. Bioinformatics. 2007 Oct 1;23(19):2612-8. DOI:10.1093/bioinformatics/btm382 |
5. Schilling M, Maiwald T, Bohl S, Kollmann M, Kreutz C, Timmer J, and Klingmüller U. Quantitative data generation for systems biology: the impact of randomisation, calibrators and normalisers. Syst Biol (Stevenage). 2005 Dec;152(4):193-200. DOI:10.1049/ip-syb:20050044 |
6. Schelter B, Winterhalder M, Maiwald T, Brandt A, Schad A, Timmer J, and Schulze-Bonhage A. Do false predictions of seizures depend on the state of vigilance? A report from two seizure-prediction methods and proposed remedies. Epilepsia. 2006 Dec;47(12):2058-70. DOI:10.1111/j.1528-1167.2006.00848.x |
7. Winterhalder M, Schelter B, Maiwald T, Brandt A, Schad A, Schulze-Bonhage A, and Timmer J. Spatio-temporal patient-individual assessment of synchronization changes for epileptic seizure prediction. Clin Neurophysiol. 2006 Nov;117(11):2399-413. DOI:10.1016/j.clinph.2006.07.312 |
8. Klingmüller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Götschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsäcker F, and Hengstler JG. Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage). 2006 Nov;153(6):433-47. DOI:10.1049/ip-syb:20050067 |
9. Fang X, Zeisel MB, Wilpert J, Gissler B, Thimme R, Kreutz C, Maiwald T, Timmer J, Kern WV, Donauer J, Geyer M, Walz G, Depla E, von Weizsäcker F, Blum HE, and Baumert TF. Host cell responses induced by hepatitis C virus binding. Hepatology. 2006 Jun;43(6):1326-36. DOI:10.1002/hep.21191 |
10. Schelter B, Winterhalder M, Maiwald T, Brandt A, Schad A, Schulze-Bonhage A, and Timmer J. Testing statistical significance of multivariate time series analysis techniques for epileptic seizure prediction. Chaos. 2006 Mar;16(1):013108. DOI:10.1063/1.2137623 |
11. Schilling M, Maiwald T, Bohl S, Kollmann M, Kreutz C, Timmer J, and Klingmüller U. Computational processing and error reduction strategies for standardized quantitative data in biological networks. FEBS J. 2005 Dec;272(24):6400-11. DOI:10.1111/j.1742-4658.2005.05037.x |
12. Goerttler PS, Kreutz C, Donauer J, Faller D, Maiwald T, März E, Rumberger B, Sparna T, Schmitt-Gräff A, Wilpert J, Timmer J, Walz G, and Pahl HL. Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2. Br J Haematol. 2005 Apr;129(1):138-50. DOI:10.1111/j.1365-2141.2005.05416.x |
13. Bertram CD, Timmer J, Müller TG, Maiwald T, Winterhalder M, and Voss HU. Aperiodic flow-induced oscillations of collapsible tubes: a critical reappraisal. Med Eng Phys. 2004 Apr;26(3):201-14. DOI:10.1016/j.medengphy.2003.11.007 |
14. Aschenbrenner-Scheibe R, Maiwald T, Winterhalder M, Voss HU, Timmer J, and Schulze-Bonhage A. How well can epileptic seizures be predicted? An evaluation of a nonlinear method. Brain. 2003 Dec;126(Pt 12):2616-26. DOI:10.1093/brain/awg265 |
15. Winterhalder M, Maiwald T, Voss HU, Aschenbrenner-Scheibe R, Timmer J, and Schulze-Bonhage A. The seizure prediction characteristic: a general framework to assess and compare seizure prediction methods. Epilepsy Behav. 2003 Jun;4(3):318-25. DOI:10.1016/s1525-5050(03)00105-7 |
16. Maiwald T, Kreutz C, Pfeifer AC, Bohl S, Klingmüller U, and Timmer J. Dynamic pathway modeling: feasibility analysis and optimal experimental design. Ann N Y Acad Sci. 2007 Dec;1115:212-20. DOI:10.1196/annals.1407.007 |
17. Frings L, Wagner K, Maiwald T, Carius A, Schinkel A, Lehmann C, and Schulze-Bonhage A. Early detection of behavioral side effects of antiepileptic treatment using handheld computers. Epilepsy Behav. 2008 Aug;13(2):402-6. DOI:10.1016/j.yebeh.2008.04.022 |
18. Schad A, Schindler K, Schelter B, Maiwald T, Brandt A, Timmer J, and Schulze-Bonhage A. Application of a multivariate seizure detection and prediction method to non-invasive and intracranial long-term EEG recordings. Clin Neurophysiol. 2008 Jan;119(1):197-211. DOI:10.1016/j.clinph.2007.09.130 |

19. Maiwald T, Winterhalder M, Aschenbrenner-Scheibe R, Voss HU, Schulze-Bonhage A, Timmer J, Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic, Physica D, 194: 357-368, 2004

20. Mammen E, Nandi S, Maiwald T, Timmer J, Effect of jump discontinuity for phase-randomized surrogate data, Int. J. Bif. Chaos, 2008

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