User:Timothee Flutre/Notebook/Postdoc/2011/11/06: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
(Autocreate 2011/11/06 Entry for User:Timothee_Flutre/Notebook/Postdoc)
 
(→‎Entry title: first third of talk E. Whitelaw)
Line 7: Line 7:
<!-- ##### DO NOT edit above this line unless you know what you are doing. ##### -->
<!-- ##### DO NOT edit above this line unless you know what you are doing. ##### -->
==Entry title==
==Entry title==
* Insert content here...
* [https://secure.ashg.org/cgi-bin/ashg_portal/index_ashg.pl?a=21&yr=2011&sid=86479746a70f0fb00513bd12c71d25ae# video] of the talk from Emma Whitelaw at the ASHG conference:
 
** epigenetics: the study of changes in gene expression which occur in the absence of mutation but which are mitotically heritable
** the epigenome undergoes dramatic reprogramming in early development, and that different cell-types acquire specific epigenomes, '''but''' how much is hard-wired and how much is modifiable by environment?
** model system: inbred mice in a "constant" environment
** example of variegation -> Agouti allele (DNA methylation at the promoter -> change in coat color). Inheritance: no difference whether the father is yellow or brown to the proportion of different coat colors in his offsprings -> clearly non-Mendelian, epigenetics marks have been cleared and reprogrammed between generations
** could these types of alleles be an explanation for complex and sporadic disease? hard to study in outbred species like humans, so look at MZ twins, but evidence for epigenetics differences is not huge
** diet of the pregnant female has an impact on the proportion of coat color in her offsprings: not a huge effect but reproducible -> epigenetic states as a record of environmental history
** 11'10''


<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### -->
<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### -->

Revision as of 09:55, 6 November 2011

Project name <html><img src="/images/9/94/Report.png" border="0" /></html> Main project page
<html><img src="/images/c/c3/Resultset_previous.png" border="0" /></html>Previous entry<html>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</html>Next entry<html><img src="/images/5/5c/Resultset_next.png" border="0" /></html>

Entry title

  • video of the talk from Emma Whitelaw at the ASHG conference:
    • epigenetics: the study of changes in gene expression which occur in the absence of mutation but which are mitotically heritable
    • the epigenome undergoes dramatic reprogramming in early development, and that different cell-types acquire specific epigenomes, but how much is hard-wired and how much is modifiable by environment?
    • model system: inbred mice in a "constant" environment
    • example of variegation -> Agouti allele (DNA methylation at the promoter -> change in coat color). Inheritance: no difference whether the father is yellow or brown to the proportion of different coat colors in his offsprings -> clearly non-Mendelian, epigenetics marks have been cleared and reprogrammed between generations
    • could these types of alleles be an explanation for complex and sporadic disease? hard to study in outbred species like humans, so look at MZ twins, but evidence for epigenetics differences is not huge
    • diet of the pregnant female has an impact on the proportion of coat color in her offsprings: not a huge effect but reproducible -> epigenetic states as a record of environmental history
    • 11'10


Retrieved from "https://openwetware.org/mediawiki/index.php?title=User:Timothee_Flutre/Notebook/Postdoc/2011/11/06&oldid=564810"