User:Timothy L. Foley

Contact Info

Tim Foley (an intoxicated interpretation)

• Timothy L. Foley
• University of California, San Diego
• Pacific Hall 6220
• 9500 Gilman Drive
• La Jolla, CA, 92093-0358
• Email me through OpenWetWare

I work in the Burkart Lab at University of California, San Diego. I am currently drafting, along with a fellow graduate student, a lab wiki that contains useful lab protocols and equipment signup calendars.

Education

• 2010*, PhD, Chemistry, University of California, San Diego *pending January 27 2010
• 2006, MS, Chemistry, University of California, San Diego
• 2004, BS, Cell Biology & Biochemistry, University of California, San Diego

Research interests

• Therapeutically active small molecules from Nature
• Enzyme structure and function
• Metabolic pathway engineering
• New antibiotics
• Neglected diseases
• Chemical genetics
• Chemical probe development
• Bacterial cell wall assembly

Publications

1. Yasgar A^†, Foley TL^†, Jadhav A, Inglese J, Burkart MD and Simeonov A. A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

   Mol. BioSyst., 2010 DOI: 10.1039/b913291k ^† co-first authors

2. Foley TL, Young BS, and Burkart MD. Phosphopantetheinyl transferase inhibition and secondary metabolism. FEBS J. 2009 Dec;276(23):7134-45. DOI:10.1111/j.1742-4658.2009.07425.x |
3. Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel JP, DiPasquale AG, Rheingold AL, and La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov;72(11):1980-7. DOI:10.1021/np9002838 |
4. Meier JL, Niessen S, Hoover HS, Foley TL, Cravatt BF, and Burkart MD. An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. ACS Chem Biol. 2009 Nov 20;4(11):948-57. DOI:10.1021/cb9002128 |
5. Foley TL and Burkart MD. A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Anal Biochem. 2009 Nov 1;394(1):39-47. DOI:10.1016/j.ab.2009.06.037 |
6. Meier JL, Barrows-Yano T, Foley TL, Wike CL, and Burkart MD. The unusual macrocycle forming thioesterase of mycolactone. Mol Biosyst. 2008 Jun;4(6):663-71. DOI:10.1039/b801397g |
7. Foley TL and Burkart MD. Site-specific protein modification: advances and applications. Curr Opin Chem Biol. 2007 Feb;11(1):12-9. DOI:10.1016/j.cbpa.2006.11.036 |
8. La Clair JJ, Foley TL, Schegg TR, Regan CM, and Burkart MD. Manipulation of carrier proteins in antibiotic biosynthesis. Chem Biol. 2004 Feb;11(2):195-201. DOI:10.1016/j.chembiol.2004.02.010 |

Useful links

• Burkart Lab Main Page
• Introductory tutorial
• OpenWetWare help pages
• my open wetware notebooks