User:Tyler Reddy

Tyler Reddy - Curriculum Vitae

Structural Bioinformatics and Computational Biochemistry Unit
Department of Biochemistry
University of Oxford
South Parks Road
Oxford, OX1 3QU
United Kingdom

Email: tyler.reddy@bioch.ox.ac.uk

Education

• University of Oxford, Oxford, United Kingdom (October 2011 – October 2014).
  

Postdoctoral Research Associate
Supervisor: Dr. Mark S. P. Sansom

• Dalhousie University, Halifax, Nova Scotia (May 2007 – July 2011).
  

PhD – Biochemistry and Molecular Biology
Thesis: Structure, Flexibility, And Overall Motion Of Transmembrane Peptides Studied By NMR Spectroscopy And Molecular Dynamics Simulations
Supervisor: Dr. Jan K. Rainey

• University of Oxford, Oxford, United Kingdom (May 2010 – Nov 2010).
  

Six month research fellowship in the laboratory of Dr. Mark S. P. Sansom
in the Department of Biochemistry. Conducted coarse-grained molecular dynamics
simulations on membrane proteins.

• Dalhousie University, Halifax, Nova Scotia (2001 – 2005).

B.Sc. – Honours Biochemistry and Molecular Biology
(Conferred May 2005 with First Class Honours)
Thesis : Mandelate racemase inhibitors: testing pentafluoromandelate
and conformationally restricted hydroxamates.
Supervisor : Dr. Stephen Bearne.

Fellowships & Awards

Postdoctoral

• Research Membership of Common Room at Kellogg College (with the standard membership fee being waived) in light of exceptional Junior Research Fellowship interview performance (Oxford, UK, 2012).
  
• HPC-Europa2 Transnational Access Programme Grant, 6 week visit to the laboratory of Dr. Marc Baaden (Paris, France) in conjunction with work at GENCI-CINES (Montpellier, France) (2012).
  
• Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship, 3 years of funding for project at University of Oxford, United Kingdom (2011-2014).
  

Graduate

• The President's Award, Dalhousie University (2010).
  
• Recognized with Canadian Interuniversity Sport (CIS) Academic All-Canadian Status (2010).
• Renewal: Izaak Walton Killam Memorial Scholarship Level 2 (2010-2011)
• NSERC Canada Graduate Scholarships – Michael Smith Foreign Study Supplement - University of Oxford (2010)
• Named to Cross Country Varsity Team at Dalhousie University (2009-2010)
• Faculty of Medicine Poster Presentation Award, Graduate Student Research Day, Dalhousie University (2009).
  
• The President's Award, Dalhousie University (2009).
  
• Natural Sciences and Engineering Research Council of Canada: Canada Graduate Scholarship D (CGS D) (2009).
  
• One of only three students nominated by Dalhousie University for an NSERC Vanier CGS D (2009).
  
• Honourary Killam Scholar, Izaak Walton Killam Predoctoral Scholarship, Dalhousie University (2009).
  
• Faculty of Graduate Studies Conference Travel Grant, Dalhousie University (2008).
  
• Travel Award, Chemical Biophysics Symposium Committee, University of Toronto (2008).
  
• Natural Sciences and Engineering Research Council of Canada: Canada Graduate Scholarship M (CGS M) (2008).
  
• Nova Scotia Health Research Foundation: Student Research Capacity Award (2007).
  
• Killam pre-doctoral fellowship, Dalhousie University (2005).
  
• Natural Sciences and Engineering Research Council of Canada: Canada Graduate Scholarship M (CGS M) (2005).
  

Undergraduate

• University Medal in Biochemistry, Dalhousie University (2005).
  
• Peter Dolphin Memorial Prize in Biochemistry, Dalhousie University (2005).
  
• Society of Chemical Industry Science Award, Dalhousie University (2005).
  
• Dalhousie In Course Scholarship, Dalhousie University (2004).
  
• Natural Sciences and Engineering Research Council of Canada: Undergraduate Student Research Award (USRA) (2004)
  
• Ross Stewart Smith Scholarship, Dalhousie University (2003).
  
• Natural Sciences and Engineering Research Council of Canada: Undergraduate Student Research Award (USRA) (2003)
  
• Natural Sciences and Engineering Research Council of Canada: Undergraduate Student Research Award (USRA) (2002)
  

Secondary

• Renewable Entrance Scholarship, Dalhousie University (2001).
  
• Governor General’s Academic Medal, Dartmouth High School (2001).
  
• DHS mathematics award, Dartmouth High School (2001).
  
• University of Toronto National Book Award, Dartmouth High School (2001).
  
• Lieutenant Governor’s Academic Medal, Dartmouth High School (2000).
  

Publications

*Equal contributions

• Reddy, T., Li, X., Fliegel, L., Sykes, B.D., and Rainey, J.K. (2010) Correlating structure, dynamics, and function in transmembrane segment VII of the Na+/H+ exchanger isoform 1. Biochim Biophys Acta: Biomembranes. 1798: 94-104.  Pubmed

• Reddy, T. and Rainey, J.K. (2010) Interpretation of biomolecular NMR spin relaxation parameters. Biochemistry and Cell Biology. 88: 131-142.  Pubmed

• Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2009) Structural insight into G-protein coupled receptor binding by apelin. Biochemistry. 48: 537-548.  Pubmed

• Reddy, T.*, Ding, J.*, Li, X., Sykes, B.D., Rainey, J.K., and Fliegel, L. (2008) Structural and Functional Characterization of Transmembrane Segment IX of the NHE1 Isoform of the Na+/H+ Exchanger. Journal of Biological Chemistry. 283: 22018-22030.  Pubmed  PDB entry (2K3C)  BMRB entry (15747)

• Baguma-Nibasheka, M., Reddy, T., Abbas-Butt, A., and Kablar, B. (2006) Fetal ocular movements and retinal cell differentiation: analysis employing DNA microarrays. Histology and histopathology. 21: 1331-1337.  Pubmed

• Reddy, T.*, Rot-Nikcevic, I.*, Downing, K.J., Belliveau, A.C., Hallgrímsson, B., Hall, B.K., and Kablar, B. (2006) Myf5-/-: MyoD-/- amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis. Development genes and evolution. 216: 1-9.  Pubmed

• Reddy, T. and Kablar, B. (2004) Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5-/-:MyoD-/- and NT-3-/- embryos. Developmental Dynamics. 231: 683-692.  Pubmed

Conference Presentations and Invited Talks

Primary presenter underlined

• Reddy, T. (2012) Conformational Dynamics of Influenza Virion with ScalaLife. ScalaLife F2F Meeting, Garching, Germany. (Invited Talk)
  

• Reddy, T., Hall, B., Chetwynd, A., and Sansom, M.S.P. (2011) Molecular Dynamics Simulations of the Transmembrane Helix of the FGFR3 Receptor in POPC and DPPC. Biophysical Society 55th Annual Meeting, Baltimore Convention Centre, Baltimore, Maryland, U.S.A (Poster)
  

• Reddy, T. (2010) Molecular dynamics simulations of the FGFR3 transmembrane domain and the spitz-rhomboid system. Structural Bioinformatics & Computational Biochemistry Unit Seminars, Department of Biochemistry, University of Oxford, Oxford, United Kingdom. (Invited talk)
  

• Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2010) Structural studies of apelin yielding insight into function. REGPEP 2010 - 18th International Symposium on Regulatory Peptides, Belfast, UK. Regulatory Peptides. 164: 39. (Poster)
  

• Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2010) Evidence for membrane-catalyzed apelin-receptor binding. MOOT XXIII NMR Symposium, Dalhousie University, Halifax, N.S. (Poster)
  

• Reddy, T., Sykes, B.D., and Rainey, J.K. (2010) Probing the effects of slow-exchange conformational sampling upon dynamics determined by peptide backbone 15N relaxation in a micellar environment. MOOT XXIII NMR Symposium, Dalhousie University, Halifax, N.S. (Poster)
  

• Reddy, T., Hall, B., Chetwynd, A., and Sansom, M.S.P. (2010) Simulations of the Transmembrane Helix of the FGFR3 Receptor. Celebrating Computational Biology: A Tribute to Frank Blaney, St. Catherine's College, University of Oxford, Oxford, U.K. (Poster)
  

• Reddy, T., Sykes, B.D., and Rainey, J.K. (2009) 15N backbone NMR relaxation studies of transmembrane segment VII of the Na+/H+ exchanger isoform 1. Nuclear Magnetic Resonance Research Resource (NMR3) 4th Annual Fall Workshop, Dalhousie University, Halifax, NS. (Poster)
  

• Reddy, T., Sykes, B.D., and Rainey, J.K. (2009) Correlating Structure, Dynamics, and Function in Transmembrane Segment VII of the Na+/H+ Exchanger Isoform 1. 52nd Annual Meeting of the CSBMCB, Niagara-on-the-Lake, Ontario. (Poster)
  

• Reddy, T., Sykes, B.D., and Rainey, J.K. (2009) 15N relaxation analysis of the Na+/H+ exchanger isoform 1 transmembrane segment VII. Graduate Student Research Day, Dalhousie University, Halifax, NS. (Poster)
  

• Reddy, T., Sykes, B.D., and Rainey, J.K. (2009) Model-free analysis and reduced spectral density mapping of a micelle-solubilized peptide using 15N relaxation data. Chemical Biophysics Symposium, Toronto, ON. (Poster)
  

• Reddy, T. (2009) Kinky Peptides: 15N Backbone NMR Relaxation Studies of a Na+/H+ Exchanger Isoform 1 Transmembrane Segment. Chemical Biology and Chemical Biophysics Networking Retreat, Halifax, NS. (Oral presentation)
  

• Reddy, T. (2008) Structure and Dynamics of Na+/H+ Exchanger Isoform 1 (NHE1) Transmembrane Segments. 3rd Annual Atlantic Region Magnetic Resonance Centre NMR Spectroscopy Workshop, Halifax, NS. (Oral presentation)
  

• Reddy, T. (2008) Structural study of the Na+/H+ exchanger isoform 1 (NHE1) transmembrane segment IX in micelles. Biochemistry 640--Biomembranes Discussion Group, University of Alberta, Edmonton, AB. (Invited talk)

• Reddy, T., Ding, J., Li, X., Sykes, B.D., Fliegel, L., and Rainey, J.K. (2008) Correlating structure and function for transmembrane segment IX of the human Na+/H+ exchanger isoform 1. XXIIIrd International Conference on Magnetic Resonance in Biological Systems (ICMRBS), San Diego, CA. (Poster)

• Rainey, J.K., Langelaan, D.N., and Reddy, T. (2008) Detecting and Dealing With Conformational Sampling in Peptides. XXIIIrd International Conference on Magnetic Resonance in Biological Systems (ICMRBS), San Diego, CA. (Poster)

• Lemieux, M.J., Lamoureux, J., Mak, M., Fischer, S., Rainey, J.K., Reddy, T., and James, M. (2008) Structural and Functional Studies of the Rhomboid Intramembrane Peptidase from H. influenzae. The 22nd Annual Symposium of the Protein Society, San Diego, CA. (Poster)
  

• Reddy, T., Ding, J., Sykes, B.D., Fliegel, L., and Rainey, J.K. (2008) Structural and Functional Characterization of Transmembrane Segment IX of the Na+/H+ Exchanger Isoform 1. Graduate Student Research Day, Dalhousie University, Halifax, NS. (Poster)
  

• Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2008) NMR, circular dichroism & fluorescence spectroscopy provide insight into conformational sampling of apelin. Graduate Student Research Day, Dalhousie University, Halifax, NS. (Poster)
  

• Reddy, T., Ding, J., Li, X., Sykes, B.D., Fliegel, L., and Rainey, J.K. (2008) Structure and topology of transmembrane segment IX of the human Na+/H+ exchanger isoform 1. 33rd Annual APICS/CIC Undergraduate Chemistry Conference, Halifax, NS. (Oral presentation)
  

• Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2008) Structure in a Random Coil Peptide: The Apelin Story. 33rd Annual APICS/CIC Undergraduate Chemistry Conference, Halifax, NS. (Poster)
  

• Reddy, T., Ding, J., Sykes, B.D., Fliegel, L., and Rainey, J.K. (2008) Structural and functional characterization of transmembrane segment IX of the Na+/H+ exchanger isoform 1. Chemical Biophysics Symposium, Toronto, ON. (Poster)
  

• Langelaan, D.N., Bebbington, E.M., Reddy, T., and Rainey, J.K. (2008) NMR, circular dichroism & fluorescence spectroscopy provide insight into the random-coil nature of apelin peptides. Chemical Biophysics Symposium, Toronto, ON. (Poster)
  

• Langelaan, D.N., Bebbington, E.M., Reddy, T., Grant, M., and Rainey, J.K. (2008) Conformational sampling by apelin peptides gives functional insight. Joint 52nd Annual Meeting of the Biophysical Society & 16th IUPAB International Biophysics Congress, Long Beach, CA. (Poster)
  

• Reddy, T. and Rainey, J.K. (2007) NMR of transmembrane peptides. Atlantic Region Magnetic Resonance Centre NMR Spectroscopy Workshop, Halifax, NS. (Poster)
  

• Kablar, B. and Reddy, T. (2004) The Role of Neurotrophins in the Esophageal Skeletal Muscle Transdifferentiation and Acetylcholine Receptor Transition. Society for Developmental Biology 63rd Annual Meeting, Calgary, AB. Developmental Biology. 271: 624. (Poster)
  

Upcoming Conference Presentations and Invited Talks

Primary presenter underlined

• Reddy, T. (2012) Cutting through the membrane: the multifaceted substrate capture scheme of a rhomboid protease. Institut de Biologie Physico-Chimique Seminar, Paris, France. (Invited Talk)
  

• Banks, A.W., Ngweniform, P., Wieczorek, M., Bebbington, E.M., Langelaan, D.N., Reddy, T., and Rainey, J.K. (2012) Computational underpinning of electronic circular dichroism and nuclear magnetic resonance spectroscopy of polypeptides. 95th Canadian Chemistry Conference, Calgary, AB. (Poster)
  

Teaching Assistantships

• Biochemistry for Pharmacy Students, Laboratory Instruction and Grading, Department of Biochemistry and Molecular Biology, Dalhousie University (2008).

• Biochemistry for Nursing Students and Introductory Biochemistry, Assignment and Midterm Grading, Department of Biochemistry and Molecular Biology, Dalhousie University (2008).

• Developmental Biology, Laboratory Instruction and Grading, Department of Biology, Dalhousie University (2005).

• Developmental Biology, Laboratory Instruction and Grading, Department of Biology, Dalhousie University (2004).

Training Camps

• Sun Microsystems Application Tuning Seminar, Halifax, Nova Scotia, Canada (2009).

• Nuclear Magnetic Resonance (NMR) Boot Camp, The National High Field Nuclear Magnetic Resonance Centre (NANUC), Edmonton, Alberta, Canada (2007).

• Canadian Forces Leadership and Recruit School, St-Jean-Sur-Richelieu, Quebec, Canada (2007).