User:Wayne G. Shreffler: Difference between revisions
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Revision as of 14:08, 14 May 2010
Contact Info
Wayne G. Shreffler, MD, PhD
MassGeneral Hospital for Children &
MGH, Center for Immunology and Inflammatory Diseases
Bldg. 149-13th St. Rm. 8312
Charlestown MA 02129
Links:
Education
- 1998, MD, New York University
- 1997, PhD, New York University
- 1996, MS, New York University
- 1991, BS, University of Washington
Research interests
- Mechanisms of Allergenicity
- Immune Tolerance and Food Allergy
- Mechanisms of Immediate Hypersensitivity and its Regulation
Publications
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PubMed Link
Selected Research Articles
- Wanich N, Nowak-Wegrzyn A, Sampson HA, and Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr;123(4):789-94.e20. DOI:10.1016/j.jaci.2008.12.1128 |
- Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, and Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan;123(1):43-52.e7. DOI:10.1016/j.jaci.2008.09.051 |
- Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, and Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar;121(3):737-743.e10. DOI:10.1016/j.jaci.2007.11.039 |
- Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, and Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15;177(6):3677-85. DOI:10.4049/jimmunol.177.6.3677 |
- Shreffler WG, Lencer DA, Bardina L, and Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct;116(4):893-9. DOI:10.1016/j.jaci.2005.06.033 |
- Shreffler WG, Beyer K, Chu TH, Burks AW, and Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr;113(4):776-82. DOI:10.1016/j.jaci.2003.12.588 |
Selected Review Articles
- Lin J, Bardina L, and Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009;524:259-72. DOI:10.1007/978-1-59745-450-6_19 |
- Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb;123(2):352-3. DOI:10.1016/j.jaci.2008.12.1119 |
- Moloney M and Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov;101(5):544-9. DOI:10.1016/S1081-1206(10)60295-5 |
- Berin MC and Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun;121(6):1311-20; quiz 1321-2. DOI:10.1016/j.jaci.2008.04.023 |
- Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):226-33. DOI:10.1097/01.all.0000225165.83144.2f |
Test
- Aceves SS, Newbury RO, Dohil MA, Bastian JF, and Dohil R. A symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammation. Ann Allergy Asthma Immunol. 2009 Nov;103(5):401-6. DOI:10.1016/S1081-1206(10)60359-6 |
- Assa'ad A. Detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seem. Ann Allergy Asthma Immunol. 2005 Oct;95(4):309-11. DOI:10.1016/S1081-1206(10)61145-3 |
- Aceves SS and Ackerman SJ. Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009 Feb;29(1):197-211, xiii-xiv. DOI:10.1016/j.iac.2008.10.003 |
- Aceves SS, Newbury RO, Dohil R, Bastian JF, and Broide DH. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Jan;119(1):206-12. DOI:10.1016/j.jaci.2006.10.016 |
- Almansa C, Krishna M, Buchner AM, Ghabril MS, Talley N, DeVault KR, Wolfsen H, Raimondo M, Guarderas JC, and Achem SR. Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol. 2009 Apr;104(4):828-33. DOI:10.1038/ajg.2008.169 |
- Aceves SS, Newbury RO, Dohil R, Schwimmer J, and Bastian JF. Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder. J Clin Gastroenterol. 2007 Mar;41(3):252-6. DOI:10.1097/01.mcg.0000212639.52359.f1 |
- Aceves SS, Newbury RO, Chen D, Mueller J, Dohil R, Hoffman H, Bastian JF, and Broide DH. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy. 2010 Jan;65(1):109-16. DOI:10.1111/j.1398-9995.2009.02142.x |
