User:Xi Chen: Difference between revisions

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== Personal/Lab Info ==  
== Contact ==  
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xichen at mail dot utexas dot edu
 
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Revision as of 09:23, 29 March 2011

Xi Chen

Xi Chen (an artistic interpretation)

Xi Chen is currently a post-doc fellow in the lab of Andrew D. Ellington in the University of Texas at Austin. He is also a visiting fellow of the Yin Lab in Wyss Institute of Harvard University.

Research

The first 3 years of my graduate study were spent primarily on engineering ribozyme-based RNA regulators in mammalian cells. Although I have created a few unpublished RNA regulators that work minimally (by my standard), my main achievement was the development of a method to directly select physiologically active ribozymes in mammalian cells, and a kinetic model to analyze and direct such selections. I then expended this kinetic model to analyze and predict the performance of ribozyme- and deoxyribozyme-based sensors in vitro and in vivo.

Since late 2008, I became interested in enzyme-free DNA circuits developed by the Winfree Lab and the Pierce Lab in Caltech. I have started designing and executing similar circuits for the purpose of biosensing and pattern formation.

After graduation, I stayed in the Ellington Lab to keep working on DNA circuits.

Selected Publications

(Note: * denotes corresponding author or co-corresponding author)

  1. Eckhoff G, Codrea V, Ellington AD, Chen X*. (2010) Beyond allostery: Catalytic regulation of a deoxyribozyme through an entropy-driven DNA amplifier. J Syst Chem. 1:13
  2. Chen X, Ellington AD. (2010) Shaping up nucleic acid computation (Review). Curr Opin Biotechnol. 21(4):392-400
  3. Chen X, Ellington AD. (2009) Design Principles for Ligand-Sensing, Conformation-Switching Ribozymes. PLoS Comput Biol. 5(12):e1000620
  4. Chen X, Denison L, Levy M, Ellington AD. (2009) Direct selection for ribozyme cleavage activity in cells RNA;15(11):2035-45
  5. Chen X, Li N, Ellington AD. (2007) Ribozyme catalysis of metabolism in the RNA world. (Review) Chem Biodivers. 4(4):633-55.
  6. Chen X, Wang Y, Liu Q, Zhang Z, Fan C, He L. (2006) Construction of molecular logic gates with a DNA-cleaving deoxyribozyme. Angew Chem Int Ed Engl. 45(11):1759-62.


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Contact

xichen at mail dot utexas dot edu

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