User:Yusuf Tutar

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Yusuf Tutar (an artistic interpretation)

• Yusuf Tutar
• Cumhuriyet University, Faculty of Pharmacy
• Department of Basic Sciences
• Division of Biochemistry
• Sivas, 58140, TURKEY
• Email me through OpenWetWare

Dr. Yusuf TUTAR is the Head of Biochemistry Division and the head of Basic Sciences Department at Faculty of Pharmacology, Cumhuriyet University, Sivas Turkey. Dr. Tutar is also the Head of Biomedical Engineering Program at the same university. He obtained his M.Sc. and Ph.D. at Oregon State University and Texas Tech University respectively. He pursued his postdoctoral study at National Institutes of Health (NIH/NIDDK), USA. His research focuses on Biochemistry, Biophysics, Genetics and Molecular Biology with specialization in the fields of protein structure-function, protein folding, prion, microrna, pseudogenes, molecular cancer, proteomics, genomics, protein expression and characterization by spectroscopic and calorimetric methods.

Education

• 2005, VF, National Institutes of Health
• 2003, PhD, Texas Tech University
• 1998, MS, Oregon State University
• 1994, BS, Cumhuriyet University

Research interests

1. Molecular Cancer Research (Prostate, thyroid, renal, colon) and epigenetic (RT-PCR and Microarray).
2. MicroRNA, pseudogens and transfection.
3. Prion, translation termination in eukaryotes, and transcription initiation in prokaryotes.
4. Investigating structure-function relationship of biological macromolecules with biochemical, biophysical, genetics and molecular biological methods.
5. Recombinant DNA technology, molecular sub-cloning, transformation and protein expression.
6. Protein purification (Heat shock, Catabolite repressorand S100P proteins) and characterisation (Spectroscopy:Fluorescence, Luminescence, CD, FTIR; Calorimetry: NanoDSC and ITC; Chromatography: HPLC and FPLC; Other techniques: MALDI-TOF, GC, SPR)

Publications

1. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15(5):429. DOI:10.2174/138920101505140828161335 |
2. Tutar L, Tutar E, and Tutar Y. MicroRNAs and cancer; an overview. Curr Pharm Biotechnol. 2014;15(5):430-7. DOI:10.2174/1389201015666140519095304 |
3. Acibucu F, Dökmetaş HS, Tutar Y, Elagoz S, and Kilicli F. Correlations between the expression levels of micro-RNA146b, 221, 222 and p27Kip1 protein mRNA and the clinicopathologic parameters in papillary thyroid cancers. Exp Clin Endocrinol Diabetes. 2014 Mar;122(3):137-43. DOI:10.1055/s-0034-1367025 |
4. Ozgur A and Tutar Y. Therapeutic proteins: A to Z. Protein Pept Lett. 2013 Dec;20(12):1365-72. DOI:10.2174/092986652012131112125148 |
5. Coskun KA, Ozgür A, Otag B, Mungan M, and Tutar Y. Heat shock protein 40-Gok1 isolation from Toxoplasma gondii RH strain. Protein Pept Lett. 2013 Dec;20(12):1294-301. DOI:10.2174/092986652012131112113608 |
6. Tutar Y. Editorial: structural characteristics of short peptides solution recombinant therapeutic protein vaccines. Protein Pept Lett. 2013 Dec;20(12):1293. DOI:10.2174/092986652012131112111741 |
7. Coşkun KA, Ozçelik S, Tutar L, Elaldı N, and Tutar Y. Isolation and identification of free-living amoebae from tap water in Sivas, Turkey. Biomed Res Int. 2013;2013:675145. DOI:10.1155/2013/675145 |
8. Gülnahar Y, Köşger HH, and Tutar Y. The role of preoperative oxidative stress and mandibular third molar postoperative outcome--reply. Int J Oral Maxillofac Surg. 2013 Nov;42(11):1500-1. DOI:10.1016/j.ijom.2013.07.002 |
9. Aykaç Fas B, Tutar Y, and Haliloğlu T. Dynamic fluctuations provide the basis of a conformational switch mechanism in apo cyclic AMP receptor protein. PLoS Comput Biol. 2013;9(7):e1003141. DOI:10.1371/journal.pcbi.1003141 |
10. Tutar Y, Coskun KA, and Tutar L. Hsp70 from Cyprinion macrostomus macrostomus and Garra rufa obtuse: stability and stability-dependent activity. Biochemistry (Mosc). 2013 May;78(5):531-5. DOI:10.1134/S0006297913050118 |
11. Koca İ, Özgür A, Coşkun KA, and Tutar Y. Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety. Bioorg Med Chem. 2013 Jul 1;21(13):3859-65. DOI:10.1016/j.bmc.2013.04.021 |
12. Gülnahar Y, Hüseyin Köşger H, and Tutar Y. A comparison of piezosurgery and conventional surgery by heat shock protein 70 expression. Int J Oral Maxillofac Surg. 2013 Apr;42(4):508-10. DOI:10.1016/j.ijom.2012.10.027 |
13. Tutar Y. Pseudogenes. Comp Funct Genomics. 2012;2012:424526. DOI:10.1155/2012/424526 |
14. Tutar Y. Hsp70 in oncology. Recent Pat DNA Gene Seq. 2011 Dec;5(3):214-8. DOI:10.2174/187221511797636293 |
15. Tutar Y. Neglected role of cAMP receptor protein monomer. Mol Biol Rep. 2012 Apr;39(4):4261-5. DOI:10.1007/s11033-011-1212-5 |
16. Tutar Y, Arslan D, and Tutar L. Heat, pH induced aggregation and surface hydrophobicity of S. cerevesiae Ssa1 protein. Protein J. 2010 Oct;29(7):501-8. DOI:10.1007/s10930-010-9280-2 |
17. Tutar Y. Therapeutic use of heat shock proteins and essential factors in prognosis, diagnosis and treatment of neurodegenerative and metabolic diseases. Curr Pharm Biotechnol. 2010 Feb;11(2):138. DOI:10.2174/138920110790909722 |
18. Tutar L and Tutar Y. Heat shock proteins; an overview. Curr Pharm Biotechnol. 2010 Feb;11(2):216-22. DOI:10.2174/138920110790909632 |
19. Tutar Y. Prelude; cellular mechanics. Protein Pept Lett. 2009;16(6):570. DOI:10.2174/092986609788490203 |
20. Tutar Y. Syn, anti, and finally both conformations of cyclic AMP are involved in the CRP-dependent transcription initiation mechanism in E. coli lac operon. Cell Biochem Funct. 2008 Jun;26(4):399-405. DOI:10.1002/cbf.1462 |
21. Tutar L and Tutar Y. Ydj1 but not Sis1 stabilizes Hsp70 protein under prolonged stress in vitro. Biopolymers. 2008 Mar;89(3):171-4. DOI:10.1002/bip.20881 |
22. Tutar Y. Chemical linkage at allosteric activation of E. coli cAMP receptor protein. Protein J. 2008 Jan;27(1):21-9. DOI:10.1007/s10930-007-9104-1 |
23. Tutar Y. Therapeutic use of Heat Shock Protein 70. Recent Pat DNA Gene Seq. 2007;1(2):125-7. DOI:10.2174/187221507780887090 |
24. Tomlinson SR, Tutar Y, and Harman JG. CRP subunit association and hinge conformation changes in response to cAMP binding: analysis of C-helix cysteine-substituted CRP. Biochemistry. 2006 Nov 14;45(45):13438-46. DOI:10.1021/bi0610855 |
25. Tutar Y. Heat shock proteins, substrate specificity and modulation of function. Protein Pept Lett. 2006;13(7):699-705. DOI:10.2174/092986606777790593 |
26. Tutar Y. Key residues involved in Hsp70 regulatory activity and affect of co-chaperones on mechanism of action. Protein Pept Lett. 2006;13(7):693-8. DOI:10.2174/092986606777790601 |
27. Tutar Y and Harman JG. Effect of salt bridge on transcription activation of CRP-dependent lactose operon in Escherichia coli. Arch Biochem Biophys. 2006 Sep 15;453(2):217-23. DOI:10.1016/j.abb.2006.06.019 |
28. Tutar Y. Target peptide recognition by S100P protein and role of central linker region and dimer interface. Protein Pept Lett. 2006;13(3):307-11. DOI:10.2174/092986606775338380 |
29. Tutar Y. Dimerization and ion binding properties of S100P protein. Protein Pept Lett. 2006;13(3):301-6. DOI:10.2174/092986606775338425 |
30. Tutar Y, Song Y, and Masison DC. Primate chaperones Hsc70 (constitutive) and Hsp70 (induced) differ functionally in supporting growth and prion propagation in Saccharomyces cerevisiae. Genetics. 2006 Feb;172(2):851-61. DOI:10.1534/genetics.105.048926 |
31. Song Y, Wu YX, Jung G, Tutar Y, Eisenberg E, Greene LE, and Masison DC. Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication. Eukaryot Cell. 2005 Feb;4(2):289-97. DOI:10.1128/EC.4.2.289-297.2005 |
32. Tomlinson SR, Tutar Y, and Harman JG. Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Biochemistry. 2003 Apr 8;42(13):3759-65. DOI:10.1021/bi027126o |

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33. Chapter Anti-Apoptotic and Oncogenic Function of HSP27 isbn=978-1-60805-863-1

34. Chapter Heat Shock Response Agents and the Diseases isbn=978-1-60805-863-1

35. Chapter Toxoplasma gondii and Heat Shock Proteins in Microbial pathogens and strategies for combating them isbn=978-84-942134-1-0.

36. Chapter Neurodegenererative Diseases, Role of Protein Aggregation in Neurodegenerative Diseases isbn=980-953-307-722-7

37. Chapter Enzymes, Instant Notes In Biochemistry, Turkish Translation of the Chapter isbn=978-605-395-288-6

38. Chapter Amino Asids, Instant Notes In Biochemistry, Turkish Translation of the Chapter isbn=978-605-395-288-6

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